The anti-inflammatory activity of licorice, a widely used Chinese herb

Yang, Rui; Yuan, Bochuan; Ma, Yongsheng; Zhou, Shiyue; Liu, Ying

doi:10.1080/13880209.2016.1225775

Cited by 291 publications

(207 citation statements)

References 89 publications

Supporting

Mentioning

199

Contrasting

Unclassified

Order By: Relevance

“…DNA authentication, combined with chemometric analyses of major flavanones and chalcones, enabled the characterization of mixtures, hybrids, and species outliers (Simmler et al, ; Song et al, ). In pharmacological and clinical studies, Glycyrrhizae Radix et Rhizoma had several pharmacological properties including antioxidant, anti‐inflammatory, anticancer, and immunomodulatory properties (Chen, Li, & Gu, ; Hosseinzadeh & Nassiri‐Asl, ; Yang, Yuan, Ma, Zhou, & Liu, ). Glycyrrhetinic acid markedly upregulated the activities of the antioxidant enzymes and increased the content of skin collagen, whereas it obviously downregulated the expression of inflammatory cytokines in vitro (Kong et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Cinnamaldehyde inhibited proliferation of colorectal cancer cells SW480, HCT116, and LoVo; human breast cancer cells MCF-7; and human non-small lung cancer cells (Li, Teng, et al, 2016;Rad et al, 2015;Wu et al, 2017). Zhou, & Liu, 2017). Glycyrrhetinic acid markedly upregulated the activities of the antioxidant enzymes and increased the content of skin collagen, whereas it obviously downregulated the expression of inflammatory cytokines in vitro (Kong et al, 2015).…”

Section: Figurementioning

confidence: 99%

See 1 more Smart Citation

Herbal medicine for hand–foot syndrome induced by fluoropyrimidines: A systematic review and meta‐analysis

Deng

Sun

2018

Phytotherapy Research

View full text Add to dashboard Cite

The aims of this study were to evaluate the efficacy of herbal medicine for the prevention and management of hand-foot syndrome (HFS) induced by fluoropyrimidines and to identify herbs associated with HFS alleviation for further research. The PubMed, Cochrane, Springer, China National Knowledge Infrastructure, and Wanfang databases were searched up to May 2017 for randomized controlled trials (RCTs) that evaluated herbal medicine for relieving HFS in patients undergoing fluoropyrimidine-based chemotherapy. Study evaluation and synthesis methods were in accordance with the Cochrane Handbook, and data were analyzed using RevMan 5.3. In total, 35 RCTs (2,668 participants) were included. Meta-analysis showed that the addition of herbal medicine significantly reduced the incidences of all-grade and high-grade HFS. The total effective rate and complete remission rate of HFS patients increased significantly with herbal medicine arm. Further sensitivity analysis identified Paeoniae Radix Alba, Carthami Flos, Cinnamomi Ramulus, and Glycyrrhizae Radix et Rhizoma as being consistently associated with significant reductions in HFS incidence without important heterogeneity. However, the lack of blinding in most studies may have led to overestimation of these effects. More high-quality RCTs and experimental research are needed to confirm and investigate the efficacy of the herbs identified in this study.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Herbal medicine for hand–foot syndrome induced by fluoropyrimidines: A systematic review and meta‐analysis

Deng

Sun

2018

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…The decreased GSH levels are the main cause of increased oxidative stress in dementia [78,79]. Glycyrrhiza extract activity on oxidative stress may be associated with the isoliquiritigenin effect on the function of mitochondria [80]. Glycyrrhiza acts by decreasing oxidative stress related to different types of dementia types by reducing brain cell damage, enhancing nerve cell function, and inhibiting memory weakness [81].…”

Section: In Vitro Pharmacological/biological Properties Of G Glabra mentioning

confidence: 99%

Traditional Uses, Bioactive Chemical Constituents, and Pharmacological and Toxicological Activities of Glycyrrhiza glabra L. (Fabaceae)

et al. 2020

View full text Add to dashboard Cite

Traditional herbal remedies have been attracting attention as prospective alternative resources of therapy for diverse diseases across many nations. In recent decades, medicinal plants have been gaining wider acceptance due to the perception that these plants, as natural products, have fewer side effects and improved efficacy compared to their synthetic counterparts. Glycyrrhiza glabra L. (Licorice) is a small perennial herb that has been traditionally used to treat many diseases, such as respiratory disorders, hyperdipsia, epilepsy, fever, sexual debility, paralysis, stomach ulcers, rheumatism, skin diseases, hemorrhagic diseases, and jaundice. Moreover, chemical analysis of the G. glabra extracts revealed the presence of several organic acids, liquirtin, rhamnoliquirilin, liquiritigenin, prenyllicoflavone A, glucoliquiritin apioside, 1-metho-xyphaseolin, shinpterocarpin, shinflavanone, licopyranocoumarin, glisoflavone, licoarylcoumarin, glycyrrhizin, isoangustone A, semilicoisoflavone B, licoriphenone, and 1-methoxyficifolinol, kanzonol R and several volatile components. Pharmacological activities of G. glabra have been evaluated against various microorganisms and parasites, including pathogenic bacteria, viruses, and Plasmodium falciparum, and completely eradicated P. yoelii parasites. Additionally, it shows antioxidant, antifungal, anticarcinogenic, anti-inflammatory, and cytotoxic activities. The current review examined the phytochemical composition, pharmacological activities, pharmacokinetics, and toxic activities of G. glabra extracts as well as its phytoconstituents.

show abstract

“…Glycyrrhiza uralensis Fisch is one of the oldest and most popular herbal medicines in the world, and recorded in the pharmacopoeias of many Asian and European countries. It shows a variety of pharmacological activities, including anticancer, antiulceric, antiinflammatory, antioxidative, antiviral, hepatoprotective, expectorant, and memory enhancing activities (Asl & Hosseinzadeh, ; Woo, Hwang, Noh, & Jeong, ; Yang, Yuan, Ma, Zhou, & Liu, ). Among the bioactive compounds, triterpene saponins and flavonoids are believed to be responsible for the bioactivities (Zhang & Ye, ).…”

Section: Introductionmentioning

confidence: 99%

Preparative separation of liquiritigenin and glycyrrhetic acid from Glycyrrhiza uralensis Fisch using hydrolytic extraction combined with high‐speed countercurrent chromatography

Wang

Huang

Lü

2020

Biomedical Chromatography

View full text Add to dashboard Cite

The objective of this paper was to develop a preparative method for the isolation and purification of liquiritigenin and glycyrrhetic acid from Glycyrrhiza uralensis Fisch using hydrolytic extraction combined with high‐speed countercurrent chromatography (HSCCC). Liquiritigenin and glycyrrhetic acid were well hydrolyzed from liquiritin and glycyrrhizic acid by hydrochloric acid, respectively. The optimal extraction conditions were obtained by single‐factor and orthogonal experiments, which were 100% ethanol, 1.5 mol/L hydrochloric acid, 1:25 ratio of solid to liquid, and extracted 2 h for one time. Using the two‐phase solvent system of n‐hexane‐ethyl acetate‐methanol–water (4:5:4:5, v/v), 2.1 mg liquiritigenin (the purity was 96.5% with a recovery of 87.6%) and 12.3 mg glycyrrhetic acid (the purity was 97.1% with a recovery of 74.4%) were obtained from 315‐mg crude extraction by HSCCC. The retention ratio of stationary phase was 47.2%. Their structures were identified by HPLC, melting points, UV, Fourier‐transform infrared, Electrospray ionization‐MS, 1H nuclear magnetic resonance (NMR), and 13C NMR spectra. According to the antioxidant activity assays, liquiritigenin and glycyrrhetic acid had some scavenging abilities on 1,1‐diphenyl‐2‐picrylhydrazyl free radicals; liquiritigenin had stronger scavenging ability on hydroxyl radicals.

show abstract

The anti-inflammatory activity of licorice, a widely used Chinese herb

Abstract: Licorice and its natural compounds have demonstrated anti-inflammatory activities. More pharmacokinetic studies using different models with different dosages should be carried out, and the maximum tolerated dose is also critical for clinical use of licorice extract and purified compounds.

Cited by 291 publications

References 89 publications

Herbal medicine for hand–foot syndrome induced by fluoropyrimidines: A systematic review and meta‐analysis

Herbal medicine for hand–foot syndrome induced by fluoropyrimidines: A systematic review and meta‐analysis

Traditional Uses, Bioactive Chemical Constituents, and Pharmacological and Toxicological Activities of Glycyrrhiza glabra L. (Fabaceae)

Preparative separation of liquiritigenin and glycyrrhetic acid from Glycyrrhiza uralensis Fisch using hydrolytic extraction combined with high‐speed countercurrent chromatography

Contact Info

Product

Resources

About