Preparative separation of liquiritigenin and glycyrrhetic acid from <i>Glycyrrhiza uralensis</i> Fisch using hydrolytic extraction combined with high‐speed countercurrent chromatography

Wang, Hao; Huang, Shan; Lü, Haitao

doi:10.1002/bmc.4788

Cited by 11 publications

(6 citation statements)

References 19 publications

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“…The main bioactive flavonoid compounds in RG, LTG, and ISL were identified and isolated from the crude extract of Glycyrrhiza uralensis [ 165 , 166 ]. ISL demonstrates antioxidant, anti-inflammatory, antitumor, and hepatoprotective activities.…”

Section: Discussionmentioning

confidence: 99%

Wen Dan Tang: A Potential Jing Fang Decoction for Headache Disorders?

Pradhan

Gantenbein

et al. 2022

Medicines

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Background: Chinese herbal medicine is considered relatively safe, inexpensive, and easily accessible. Wen Dan Tang (WDT), a Jing Fang ancient classical Chinese herbal formula with a broad indication profile has been used for several centuries in China to treat various illnesses. Question: Are there evidence-based clinical trials that show that WDT has a significant impact on the treatment of various diseases, especially in patients with migraine and tension-type headaches (TTH)? Methods: This study is based on an online database search using PubMed, Medline, Cochrane Library, AcuTrials, Embase, Semantic Scholar, Jstor, internet research, and review of ancient and modern Chinese medical textbooks regarding WDT and its compounds. Results: There were no studies on WDT in migraine and TTH; therefore, this work gathers and describes data for every single compound in the formula. Conclusion: This study suggests that the bioactive compounds found in WDT composition show potential in treating patients with neurological, psychiatric disorders, cardiovascular diseases, metabolic syndrome, and digestive disorders. Some coherence between WDT in headache reduction and improvements in the quality of life in patients with migraines and TTH could be evaluated, showing positive results of WDT in these patients.

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Section: Discussionmentioning

confidence: 99%

Wen Dan Tang: A Potential Jing Fang Decoction for Headache Disorders?

Pradhan

Gantenbein

et al. 2022

Medicines

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“…GLR is commonly isolated from Glycyrrhizae Radix in the form of a monoammonium salt (C 42 H 61 O 16 _NH 4 ), but occasionally studies are performed with the magnesium salt of 18β-glycyrrhizic acid (magnesium isoglycyrrhizinate) (Cao et al, 2019;Tan et al, 2018;Zou et al, 2018). Specific methods have been developed to monitor the extraction process and for GLR dosages in biological media (Wang, Shan, & Lü, 2020;Yu et al, 2017;Zeng et al, 2020).…”

Section: Glycyrrhizin (Glr) a Natural Productmentioning

confidence: 99%

“…In addition to HMG proteins, GLR has also been shown to bind to other proteins such as serum albumin Wang, Shan, & Lü, 2020) and to recombinant HIV-1 reverse transcriptase to inhibit the protein phosphorylation (Harada et al, 1998). Binding of GA to the active site of lactate dehydrogenase from Plasmodium falciparum (malaria parasite) has been proposed based on molecular modeling, mimicking the binding of chloroquine to the same site and possibly explaining the modest antimalarial activity of GLR (Kalani et al, 2013).…”

Section: Other Targets and Mechanismsmentioning

confidence: 99%

Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?

Bailly

Vergoten

2020

Pharmacology & Therapeutics

245

205

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Safe and efficient drugs to combat the current COVID-19 pandemic are urgently needed. In this context, we have analyzed the anti-coronavirus potential of the natural product glycyrrhizic acid (GLR), a drug used to treat liver diseases (including viral hepatitis) and specific cutaneous inflammation (such as atopic dermatitis) in some countries. The properties of GLR and its primary active metabolite glycyrrhetinic acid are presented and discussed. GLR has shown activities against different viruses, including SARS-associated Human and animal coronaviruses. GLR is a non-hemolytic saponin and a potent immuno-active anti-inflammatory agent which displays both cytoplasmic and membrane effects. At the membrane level, GLR induces cholesterol-dependent disorganization of lipid rafts which are important for the entry of coronavirus into cells. At the intracellular and circulating levels, GLR can trap the high mobility group box 1 protein and thus blocks the alarmin functions of HMGB1. We used molecular docking to characterize further and discuss both the cholesterol-and HMG boxbinding functions of GLR. The membrane and cytoplasmic effects of GLR, coupled with its long-established medical use as a relatively safe drug, make GLR a good candidate to be tested against the SARS-CoV-2 coronavirus, alone and in combination with other drugs. The rational supporting combinations with (hydroxy)chloroquine and tenofovir (two drugs active against SARS-CoV-2) is also discussed. Based on this analysis, we conclude that GLR should be further considered and rapidly evaluated for the treatment of patients with COVID-19.

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“…Phenols comprise a wide variety of compounds such as polyphenols, flavonoids, condensed tannins. Phenolic compounds are mostly hydrophilic, while the flavonoids are mostly hydrophobic [30]. However, due to their structures, flavonoids such as quercetin, kaempferol and catechin were easily extracted by hydromethanolic solvents.…”

Section: Determination Of Total Phenolics Contentmentioning

confidence: 99%

Phenolic Constituents of Anethum graveolens Seed Extracts: Chemical Profile and Antioxidant Effect Studies

Bota

Stănăşel

Blidar

et al. 2021

JPRI

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The Aim of the Research: Anethum graveolens (dill) is a common herb used in traditional Romanian cuisine, as well as in phytotherapy. Dill seeds have been reported to be rich in antioxidants. As interest in food additives of natural origin has increased in recent years, the purpose of this paper was to study the composition and antioxidant potential of Romanian dill seeds. Methodology: In this study, the total phenolics contents, the phenolic profile, and the antioxidant properties of the methanolic and hydromethanolic extracts of Romanian dill seeds were investigated. Folin-Ciocalteu assay, DPPH spectrophotometrically method and reverse-phase high-performance liquid chromatography RP-HPLC, respectively were applied. Results: The highest content of total phenolics was found in acidified methanol samples (46.5 - 46.8 mg GAE/g dry seeds). RP-HPLC analysis highlights important content of quercetin, kaempferol, caffeic acid, sinapic acid, gallic acid, vanillic acid, (±) - catechin and umbelliferone. Antioxidant activity, measured via DPPH free radical scavenging ability, showed very high values (93.5 - 95.6% for the crude extracts and 67.5 - 93.2% for extracts at a concentration of 0.25 mg/mL). Methanolic extract exhibited the best IC50 value (88.7 ± 0.01 μg/mL). Conclusion: All experiments proved the antioxidant activity of dill seed extracts.

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Preparative separation of liquiritigenin and glycyrrhetic acid from Glycyrrhiza uralensis Fisch using hydrolytic extraction combined with high‐speed countercurrent chromatography

Cited by 11 publications

References 19 publications

Wen Dan Tang: A Potential Jing Fang Decoction for Headache Disorders?

Wen Dan Tang: A Potential Jing Fang Decoction for Headache Disorders?

Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?

Phenolic Constituents of Anethum graveolens Seed Extracts: Chemical Profile and Antioxidant Effect Studies

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