A Note Study on Antidiabetic Effect of Main Molecules Contained in Clove Using Molecular Modeling Interactions with DPP-4 Enzyme

Bouchentouf, Salim

doi:10.11648/j.ijctc.20170501.12

Cited by 6 publications

(3 citation statements)

References 14 publications

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“…Many plant species have pharmacological activities attributable to their phytoconstituents, for instance, glycosides, saponins, flavonoids, steroids, tannins, alkaloids and terpenes (Batiha et al, 2020). CEO includes many components such as flavonoids, alkaloids and monoterpenes, and has broad pharmacological efficacy (Osanloo, Sedaghat, Esmaeili, & Amani, 2018; Salim, 2017). Furthermore, the pharmacological effects of mentioned constituents are different, for example, the main site action of flavonoids is acetylcholinesterase (Perumalsamy, Jang, Kim, Kadarkarai, & Ahn, 2015), as well as alkaloids and monoterpenes target Na‐K‐ATPase or Na + and K + channels (Lucia, Zerba, & Masuh, 2013; Rajashekar & Shivanandappa, 2017).…”

Section: Discussionmentioning

confidence: 99%

The beneficial effect of clove essential oil and its major component, eugenol, on erectile function in diabetic rats

et al. 2020

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Diabetic men are at a higher risk of erectile dysfunction (ED). A tropical plant, clove (Syn. Eugenia caryophyllata, Caryophyllus aromaticus L., Syzygium aromaticum (L.) Merr. & L.M. Perry) from the Myrtaceae family has displayed aphrodisiac activity. The present research aimed to investigate the impacts of clove essential oil (CEO) and the ingredient of CEO, eugenol (E) on ED in diabetic rats. We divided Sprague‐Dawley rats into control and diabetic groups. Erectile function was evaluated before and after CEO and E intracavernosal injection. CEO‐ and E‐induced relaxation responses were investigated in isolated corpus cavernosum (CC) using various inhibitors. The intracavernous administration of CEO and E restored erectile responses in diabetic rats. CEO and E induced remarkable relaxation in all groups. CEO‐ and E‐induced relaxation responses were partially inhibited after pre‐contraction with KCl. Tetraethylammonium and glibenclamide inhibited the relaxation response to CEO. Glibenclamide inhibited maximum relaxation to E. The inhibitors of nitric oxide synthase (NOS), soluble guanylyl cyclase and nifedipine did not change CEO‐ and E‐induced relaxation responses. The current results suggest that CEO and the major compound of the essential oil, E improved diabetes‐induced ED in rats, and CEO caused CC relaxation via K+ channels independently NO signalling pathway.

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Section: Discussionmentioning

confidence: 99%

The beneficial effect of clove essential oil and its major component, eugenol, on erectile function in diabetic rats

et al. 2020

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“…Given this scenario, the search for new substances with antimicrobial potential becomes urgent. It is known that some groups of secondary metabolites, such as tannins, have the ability to inhibit bacterial proliferation through cell wall degradation, being considered as promising antimicrobial agents (Salim, 2017;Santos et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Chemical characterization, antimicrobial activity and cardiac effects in rat heart of the ethyl acetate fraction of Syzygium cumini (L.) Skeels

Mota

Santos

et al. 2023

RSD

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Plants are important sources of secondary metabolites responsible for various biological activities. In this research, was evaluated the effect action ethyl acetate fraction of Syzygium cumini leaves (Sc-AcOEt) in the antimicrobial activity, contractile and electrical effects in isolated rat hearts and the chemical characterization. Antimicrobial activity was assessed using the disk-diffusion method and the determination of the minimum inhibitory concentration. The contractile and electrical effects were tested using the Langendorf method. The chemical characterization was evaluated through quantification and HPLC analyzes. P. aeruginosa was not viable in any concentration of the fraction (MIC 0,125 mg/mL), while S. aureus showed a MIC of 0.5 mg/mL. K. pneumoniae and E. coli had the highest MIC (1 mg/mL). A reduction in LVDP was observed after heart perfusion with 0.1 mg/mL of Sc-AcOEt. No change was observed in the duration of systole and diastole at all concentrations and in the electrocardiographic parameters. Total phenols, total flavonoids and total flavonols contents of Sc-AcOEt, calculated from the respective calibration curves, were 21.556µg/mg AGE, 617.222µg/mg QE and 315,222µg/mg RE, respectively. In addition, the HPLC analysis of Sc-AcOEt showed the presence of gallic acid, quercetin-3-glucoside, naringin and myricetin as main components. Thus, the Sc-AcOEt has important antimicrobial and cardiac activities possibly due to its chemical constituents.

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“…Clove oil obtained from the flower buds of syzygiumaromaticum has recently received a lot of attention for its antidiabetic potential, especially in case of type 2 diabetes [21][22][23][24]. Clove oil contains eugenol and acetyleugenol, which can increase the fluidity of the lipids found in SC and can act as a penetration enhancer [24].…”

Section: Introductionmentioning

confidence: 99%

Glimepiride-Loaded Nanoemulgel; Development, In Vitro Characterization, Ex Vivo Permeation and In Vivo Antidiabetic Evaluation

Razzaq

Asif

Asghar

et al. 2021

Cells

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Glimepiride (GMP), an oral hypoglycemic agent is extensively employed in the treatment of type 2 diabetes. Transdermal delivery of GMP has been widely investigated as a promising alternative to an oral approach but the delivery of GMP is hindered owing to its low solubility and permeation. The present study was designed to formulate topical nanoemulgel GMP system and previously reported solubility enhanced glimepiride (GMP/βCD/GEL-44/16) in combination with anti-diabetic oil to enhance the hypoglycemic effect. Nanoemulsions were developed using clove oil, Tween-80, and PEG-400 and were gelled using xanthan gum (3%, w/w) to achieve the final nanoemulgel formulations. All of the formulations were evaluated in terms of particle size, zeta potential, pH, conductivity, viscosity, and in vitro skin permeation studies. In vivo hypoglycemic activity of the optimized nanoemulgel formulations was evaluated using a streptozocin-induced diabetes model. It was found that a synergistic combination of GMP with clove oil improved the overall drug permeation across the skin membrane and the hypoglycemic activity of GMP. The results showed that GMP/βCD/GEL-44/16-loaded nanoemulgel enhanced the in vitro skin permeation and improved the hypoglycemic activity in comparison with pure and marketed GMP. It is suggested that topical nano emulsion-based GMP gel and GMP/βCD/GEL-44/16 could be an effective alternative for oral therapy in the treatment of diabetes.

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A Note Study on Antidiabetic Effect of Main Molecules Contained in Clove Using Molecular Modeling Interactions with DPP-4 Enzyme

Cited by 6 publications

References 14 publications

The beneficial effect of clove essential oil and its major component, eugenol, on erectile function in diabetic rats

The beneficial effect of clove essential oil and its major component, eugenol, on erectile function in diabetic rats

Chemical characterization, antimicrobial activity and cardiac effects in rat heart of the ethyl acetate fraction of Syzygium cumini (L.) Skeels

Glimepiride-Loaded Nanoemulgel; Development, In Vitro Characterization, Ex Vivo Permeation and In Vivo Antidiabetic Evaluation

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