A non-random deletion in the p53 gene in oral squamous cell carcinoma

Nylander, Karin; Schildt, Elsy‐Britt; Magnusson, Alessandra Selinger; Mehle, Christer; Roos, Göran

doi:10.1038/bjc.1996.262

Cited by 23 publications

(14 citation statements)

References 22 publications

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“…Since variations in clinical and/or etiologic behaviors may exist among different sites in the head and neck, analysis for SCC from a single anatomic site should help determine whether a distinct biologic behavior exists. As single site analyses, laryngeal carcinoma, 24,48 oral carcinoma, 25,49,50 and oropharyngeal carcinoma 51 have been analyzed. To our knowledge, the current study is the first report describing the expression of apoptosis-related proteins and p53 mutations in a large number of maxillary sinus SCCs in relation to clinical behaviors.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of p53 mutations, bax, and spontaneous apoptosis in maxillary sinus squamous cell carcinoma

Bandoh

Hayashi

Kishibe

et al. 2002

Cancer

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Section: Discussionmentioning

confidence: 99%

Prognostic value of p53 mutations, bax, and spontaneous apoptosis in maxillary sinus squamous cell carcinoma

Bandoh

Hayashi

Kishibe

et al. 2002

Cancer

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“…In addition, Nylander et al detected a new non-random 14 bp deletion in exon 8 of OSCCs collected in Sweden. 36 Most of the patients carrying this deletion were women (80%), 60% of them were over 70 years at the time of diagnosis, and 66.7% of them did not smoke. However, only the association with female sex was significant (p = 0.02) in that study.…”

Section: Discussionmentioning

confidence: 99%

Specific p53 immunostaining patterns are associated with smoking habits in patients with oral squamous cell carcinomas

Cruz

Snijders²,

Houten³

et al. 2002

Journal of Clinical Pathology

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Aims: To identify immunostaining patterns that are predictive for p53 mutations and to investigate whether p53 mutations are associated with established risk factors for oral squamous cell carcinoma (OSCC). Methods: Fifty five OSCCs were investigated for p53 protein expression by immunohistochemistry (IHC). Ten of these cases, including five p53 immunopositive and five p53 immunonegative cases, were subjected to microdissection of representative tumour areas followed by sequence analysis for the detection of TP53 mutations. Results: Paired IHC and sequence analysis revealed that p53 immunoexpression in more than 25% of tumour cells was indicative of TP53 mutations, whereas p53 immunonegativity was not informative. Therefore, for p53 immunohistochemical interpretation, p53 immunonegative cases were excluded from the analysis and the cut off value for p53 immunoexpression was set at 25%. Of the OSCCs showing any p53 immunoexpression, 64% revealed staining in more than 25% of the tumour cells. p53 immunoexpression in more than 25% of the neoplastic cells was significantly associated with smoking but not with alcohol consumption. No significant association with smoking habits was found when OSCCs were dichotomised into p53 immunonegative and p53 immunopositive. Conclusions: In OSCCs the following conclusions can be made: (1) p53 immunonegativity is not informative for TP53 mutations; (2) 25% p53 immunopositive cells appears to be a good cut off value to predict TP53 mutations; (3) p53 immunostaining patterns that appeared to be predictive for TP53 mutations were associated with the smoking habits of the patients.

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“…Eleven women (58% of those ascertained) and 15 men (28% of those ascertained) had LOH at or above D13S118. The remainder (eight women and 38 men) had no LOH of chromosome 13 (four women and 25 men) or had LOH at loci below D13S118 (four women and 13 (Nylander et al, 1996).…”

Section: Resultsmentioning

confidence: 99%

Infrequency of BRCA2 alterations in head and neck squamous cell carcinoma

et al. 1997

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Alterations of BRCA2 result in increased susceptibility to breast cancer in both men and women (relative lifetime risks of 0.06 and 0.8 respectively). BRCA2 maps to 13q12-q13 and encodes a transcript of 10 157 bp. Other cancers that have been described in BRCA2 mutation carriers include those of the larynx. Human chromosome 13q has been shown previously by LOH studies to harbor several tumor suppressor genes for head and neck squamous cell carcinoma (HNSCCs). We therefore examined the role of BRCA2 in the development of these cancers. Only 6/22 (27%) of the laryngeal cancers we examined demonstrated LOH of the BRCA2-containing region. These and 10 other HNSCCs of dierent origins that were demonstrated by LOH studies to have lost the region of chromosome 13 containing BRCA2 were examined for alterations in this gene. SSCP analysis failed to reveal any alterations leading us to conclude that BRCA2 alterations are not frequently involved in the pathogenesis of HNSCCs and that the observed LOH of chromosome 13 loci is due to other, as yet, unidenti®ed tumor suppressor gene(s). Interestingly tumors with LOH in this region (proximal to D13S118) were far more likely to be derived from women than men. This is unusual since HNSCCs are usually fourfold more common in men than in women.

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A non-random deletion in the p53 gene in oral squamous cell carcinoma

Cited by 23 publications

References 22 publications

Prognostic value of p53 mutations, bax, and spontaneous apoptosis in maxillary sinus squamous cell carcinoma

Prognostic value of p53 mutations, bax, and spontaneous apoptosis in maxillary sinus squamous cell carcinoma

Specific p53 immunostaining patterns are associated with smoking habits in patients with oral squamous cell carcinomas

Infrequency of BRCA2 alterations in head and neck squamous cell carcinoma

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