A Non‐enzymatic Disposable Electrochemical Sensor for Pyruvic Acid

Abstract

Pyruvic acid (PA), plays an important role in metabolic pathway of living organism, and found use in health care, food, drug and agro-chemical industries. Herein, we report development of disposable silver nanoparticles decorated reduced graphene oxide (AgÀ rGO) nanocomposite electrodes for non-enzymatic detection of PA.The AgÀ rGO endowed enhanced electrochemical active area, and exhibited excellent electrochemical activity towards PA with well-defined oxidation peak at 400 mV. The sensor exhibited a linear range of 0.025-1.43 μM for PA with detection limit of 0.5 nM. The validation of developed PA sensor was performed with onion juice and, reason behind electrode fouling affect on electrochemical oxidation of PA also investigated.

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“…In addition, the Δ E p values of the PE and PMPE are greater than 60 mV, and the I pa / I pc ratios differ from unity, indicating the quasi-reversible processes. Hence, the Randles–Sevcik equation for the quasi-reversible electrochemical reaction was taken to calculate the electroactive area ,,, as follows: I normalp , normalf = prefix± 0.436 n F A C n F D ν R T where I p,f represents the forward peak current, and n is the number of electrons per molecule reduced or oxidized. A is the electroactive area of the electrode (cm 2 ), D is the diffusion coefficient of Ru(NH 3 ) 6 Cl 3 (9.10 × 10 –6 cm 2 s –1 ), F is the Faraday constant (C mol –1 ), R is the universal gas constant, T is the temperature in Kelvin, C is the concentration of Ru(NH 3 ) 6 Cl 3 , and υ is the scan rate ( V s–1 ).…”

“…In addition, the ΔE p values of the PE and PMPE are greater than 60 mV, and the I pa /I pc ratios differ from unity, indicating the quasi-reversible processes. Hence, the Randles−Sevcik equation for the quasi-reversible electrochemical reaction was taken to calculate the electroactive area 36,54,58,59 as follows:…”