A nitric oxide biosensor based on the multi-assembly of hemoglobin/montmorillonite/polyvinyl alcohol at a pyrolytic graphite electrode

A reagentless nitric oxide biosensor based on the direct electrochemistry of hemoglobin adsorbed on the gold colloids modified carbon paste electrode

“…Even so, the linear range and slopes of its regression equations represented the good sensitivity of the biosensor. The detection limit of the biosensor is 1.0 × 10 −7 M (estimated from three times standard deviation of the blank), which is slower than some other biosensors based on the direct electrochemistry of Hb [15,39].…”

“…This kind of NO sensor is very sensitive to NO determination, however, it is susceptible to some commonly substances in organism, such as dopamine, because of the positive potential for the oxidation of NO. Nowadays, many researchers tried to fabricated NO biosensor based on the catalytic reduction of NO by heme-proteins [15]. A distinctive advantage of this method is that it is based on the direct electron transfer (DET) of heme-proteins, which can be called a "third generation biosensor".…”

Electrochemistry of hemoglobin entrapped in a Nafion/nano-ZnO film on carbon ionic liquid electrode

“…Many approaches had been devised for the entrapment of the proteins with different modified films, such as insoluble surfactants [4], hydrogel [5,6], biopolymer [7,8], composite film [9,10] or nanoparticle [11]. The presence of composite film can facilitate the direct electron transfer between the protein and the electrode.…”

In Vivo Imaging of Nitric Oxide by Magnetic Resonance Imaging Techniques

“…However, most of the DAFs had reacted with serum to form fluorescent product, which imposed limitations related to reproducibility of the measurement. [97]. Low nitric oxide levels are considered potent markers of sickling and major factors responsible for the inability of red blood cells to relax arteries and oxygen deprivation.…”