A NIR-II light-modulated injectable self-healing hydrogel for synergistic photothermal/chemodynamic/chemo-therapy of melanoma and wound healing promotion

Abstract

The development of an injectable multifunctional hydrogel with tumor therapy, antibacterial treatment and wound healing properties is essential for simultaneous eradicating melanoma and promoting wound healing of tumor-initiated skin defects....

Constructing a self-healing injectable SABA/Borax/PDA@AgNPs hydrogel for synergistic low-temperature photothermal antibacterial therapy

“…Besides, as borate-diol linkages usually possess thermal- and pH-responsive reversible gel–sol transition properties, here, we conducted related experiments to evaluate the thermal- and pH-responsive performance of the SABA/Borax hydrogel. 38 Regarding the thermal-responsive performance, an obvious gel–sol phase transition of the SABA/Borax hydrogel was detected at 45 °C, 50 °C, 55 °C and 60 °C based on the inverting-vial method (Fig. S4, ESI†).…”

Nanoparticle-mediated stimulus-responsive antibacterial therapy

“…This composite offered good anti-bacterial activity (>97.1%) against both Gram-positive ( Staphylococcus aureus ) and Gram-negative ( Escherichia coli ) bacteria. 49…”

“…This composite offered good anti-bacterial activity (>97.1%) against both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. 49 Besides local heat generation, PTT can efficiently deliver antimicrobial payloads such as drugs and antibiotics into the infected sites. In the recent work by Moorcroft et al, they focused on the photothermal release of AMPs, an antimicrobial peptide.…”

Photothermal synergistic nitric oxide controlled release injectable self-healing adhesive hydrogel for biofilm eradication and wound healing

“…35 Among them, the dynamic covalent borate ester-based injectable self-healing hydrogel dressing is more suitable for skin motion wounds, in particular, the hydrogel cross-linked with boronic acid/polyphenol exhibits an excellent tissue wet-adhesion ability through a catechol-like mimicking mussel adhesion reaction with the wound wet tissue. 36 More importantly, boronic acid can also act as a functional group in the esterification with polysaccharides like lipopolysaccharides and peptidoglycans on the bacterial cell wall, thus enabling targeted bacterial attachment, amplifying bacterial accumulation on the hydrogel dressing and enhancing the anti-infection effect. 37,38…”