Nanoparticle-mediated stimulus-responsive antibacterial therapy

Bag, Neelanjana; Bardhan, Souravi; Roy, Shubham; Roy, Jhilik; Mondal, Dhananjoy; Das, Sukhen; Guo, Bing

doi:10.1039/d2bm01941h

Cited by 21 publications

(15 citation statements)

References 102 publications

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“…Huang et al (2023) conducted a comprehensive survey of state-of-the-art image-guided techniques for diagnosing and treating bacterial infections, including photothermal treatment, photodynamic therapy, chemodynamic therapy, sonodynamic therapy, immunotherapy, and various other therapies . Along with these advanced therapies, researchers have also focused on utilizing the physiochemical properties of NPs to release drugs through various stimuli such as sound, light, pH, electric, and magnetic fields to overcome multidrug resistance . The ability to employ physiochemical properties of NPs to release drugs through stimuli shows promise for overcoming multidrug resistance.…”

Section: Nanotechnological Approaches For Biofilm Controlmentioning

confidence: 99%

Advances in Nanotechnology for Biofilm Inhibition

et al. 2023

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Biofilm-associated infections have emerged as a significant public health challenge due to their persistent nature and increased resistance to conventional treatment methods. The indiscriminate usage of antibiotics has made us susceptible to a range of multidrug-resistant pathogens. These pathogens show reduced susceptibility to antibiotics and increased intracellular survival. However, current methods for treating biofilms, such as smart materials and targeted drug delivery systems, have not been found effective in preventing biofilm formation. To address this challenge, nanotechnology has provided innovative solutions for preventing and treating biofilm formation by clinically relevant pathogens. Recent advances in nanotechnological strategies, including metallic nanoparticles, functionalized metallic nanoparticles, dendrimers, polymeric nanoparticles, cyclodextrin-based delivery, solid lipid nanoparticles, polymer drug conjugates, and liposomes, may provide valuable technological solutions against infectious diseases. Therefore, it is imperative to conduct a comprehensive review to summarize the recent advancements and limitations of advanced nanotechnologies. The present Review encompasses a summary of infectious agents, the mechanisms that lead to biofilm formation, and the impact of pathogens on human health. In a nutshell, this Review offers a comprehensive survey of the advanced nanotechnological solutions for managing infections. A detailed presentation has been made as to how these strategies may improve biofilm control and prevent infections. The key objective of this Review is to summarize the mechanisms, applications, and prospects of advanced nanotechnologies to provide a better understanding of their impact on biofilm formation by clinically relevant pathogens.

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Section: Nanotechnological Approaches For Biofilm Controlmentioning

confidence: 99%

Advances in Nanotechnology for Biofilm Inhibition

et al. 2023

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“…Carbonaceous nanomaterials are favorable candidates in biomedical applications due to their extensive physicochemical properties and negligible cytotoxicity. [108][109][110][111][112] Precisely, sp 2 hybridized carbon nanostructures such as graphene, and carbon nanotubes (CNTs) have efficient photo-absorption in the NIR regime and thus they became useful for PTT. Moreover, the bactericidal effect of carbon nanoparticles owing to their membrane stress, oxidative stress, and electron transfer is extremely useful to ablate bacteria.…”

Section: Nanomaterials As Multimodal Ptasmentioning

confidence: 99%

“…Superbugs or in other words multidrug-resistant bacteria (MDR) are becoming a severe threat to humankind. 1,2 It is estimated that within the year 2050, billions of people will die every year due to superbug-mediated diseases. 3 Superbugs are the fruits of uncontrolled misuse of antibiotics and other drugs.…”

Section: Introductionmentioning

confidence: 99%

“…6 Primarily, dynamic therapies have achieved tremendous success due to their simplicity and efficacy. 2 These dynamic therapies are stimulus-based (both intrinsic and extrinsic) and can be classified by the nature of the stimulus. 7 These stimulus-based dynamic therapies produce reactive radicals (especially reactive oxygen and nitrogen species) inside the infected cells and inhibit them.…”

Section: Introductionmentioning

confidence: 99%

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Nanomaterials as multimodal photothermal agents (PTAs) against ‘Superbugs’

Roy

Guo

2023

J. Mater. Chem. B

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“…23,24 Recently, nanoparticle-mediated therapy has shown potential for antibacterial treatment. 25 Among them, silver nanoparticles (AgNPs) with diameters of 1−100 nm (mostly 25−50 nm) have been widely used in wound healing owing to their broadspectrum antibacterial properties and lack of drug resistance. 26,27 Nevertheless, their application is limited by their high toxicity at effective concentrations.…”

Section: Introductionmentioning

confidence: 99%

Collagen–Hyaluronic Acid Composite Hydrogels with Applications for Chronic Diabetic Wound Repair

Liang,

Dong,

Guo

et al. 2023

ACS Biomater. Sci. Eng.

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Chronic diabetic wounds have become a major healthcare challenge worldwide. Improper treatment may lead to serious complications. Current treatment methods including biological and physical methods and skin grafting have limitations and disadvantages, such as poor efficacy, inconvenience of use, and high cost. Therefore, developing a more effective and feasible treatment is of great significance for the repair of chronic diabetic wounds. Hydrogels can be designed to serve multiple functions to promote the repair of chronic diabetic wounds. Furthermore, 3D bioprinting enables hydrogel customization to fit chronic diabetic wounds, thus facilitating the healing process. This paper reports a study of 3D printing of a collagen−hyaluronic acid composite hydrogels with application for chronic diabetic wound repair. In situ printed hydrogels were developed by a macromolecular crosslinking network using methacrylated recombinant human collagen (RHCMA) and methacrylated hyaluronic acid (HAMA), both of which can respond to ultraviolet (UV) irradiation. The hydrogels were also loaded with silver nanoclusters (AgNCs) with ultra-small-size nanoparticles, which have the advantages of deep penetration ability and broad-spectrum high-efficiency antibacterial properties. The results of this study show that the developed RHCMA, HAMA, and AgNCs (RHAg) composite hydrogels present good UV responsiveness, porosity, mechanical properties, printability, and biocompatibility, all of which are beneficial to wound healing. The results of this study further show that the developed RHAg hydrogels not only effectively inhibited Staphylococcus aureus and Pseudomonas aeruginosa but also promoted the proliferation and migration of fibroblasts in vitro and tissue regeneration and collagen deposition in vivo, thus producing a desirable wound repair effect and can be used as an effective functional biomaterial to promote chronic diabetic wound repair.

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Nanoparticle-mediated stimulus-responsive antibacterial therapy

Abstract: The limitations faced by conventional antibacterial therapies and the subsequent amplification of multidrug-resistant (MDR) microorganisms have increased, necessitating the urgent development of innovative antibacterial techniques. Nanoparticle-mediated therapeutics have emerged as...

Cited by 21 publications

References 102 publications

Advances in Nanotechnology for Biofilm Inhibition

Advances in Nanotechnology for Biofilm Inhibition

Nanomaterials as multimodal photothermal agents (PTAs) against ‘Superbugs’

Collagen–Hyaluronic Acid Composite Hydrogels with Applications for Chronic Diabetic Wound Repair

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