A newly synthesized photostable retinol derivative (retinyl N-formyl aspartamate) for photodamaged skin: Profilometric evaluation of 24-week study

Lee, Min-Suk; Lee, Kyung-Ho; Sin, Hong‐Sig; Um, Soo‐Jong; Kim, Jin-Wou; Koh, Bo‐Kyung

doi:10.1016/j.jaad.2006.01.013

Cited by 21 publications

(15 citation statements)

References 16 publications

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“…Although not randomized and lacking power, statistically significant improvement in objective and subjective skin surface characteristics were found, with only one patient reporting skin irritation. 63 Most recently, the photostable retinyl retinoate has been investigated. Retinyl retinoate is a synthetic retinoid that combines retinol and retinoic acid molecules with an ester bond.…”

Section: Clinical Evidencementioning

confidence: 99%

Reversal of Skin Aging with Topical Retinoids

Hubbard

Unger²,

Rohrich

2014

Plastic &Amp; Reconstructive Surgery

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Topical skin care and its place in plastic surgery today are often overlooked by clinicians formulating a plan for facial rejuvenation. Not only is it important to consider topical skin care as part of comprehensive care, but clinicians should also be educated with the data available in today's literature. This review aims to familiarize the reader with the biological processes of skin aging and evidence-based clinical outcomes afforded by various topical therapies. Furthermore, this review will focus on solar damage, the value of retinoids, and how they can be used in conjunction with forms of treatment such as chemical peel, dermabrasion, and lasers. Finally, guidelines will be provided to help the physician administer appropriate skin care based on the data presented.

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Section: Clinical Evidencementioning

confidence: 99%

Reversal of Skin Aging with Topical Retinoids

Hubbard

Unger²,

Rohrich

2014

Plastic &Amp; Reconstructive Surgery

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“…A synthetic derivative of retinol, retinyl N-formyl aspartamate, was also found to be effective in improving skin roughness and fine wrinkles in a placebo-controlled study of 24 Korean women during a 24-week period with minimal reports of skin irritation. 49 However, clear examples remain as to why we as clinicians cannot assume that all retinoids are equal. The results of clinical trials examining the use of retinyl esters for the treatment of photoaging have been routinely disappointing.…”

Section: Vitamins As Therapymentioning

confidence: 99%

Vitamins and photoaging: Do scientific data support their use?

Zussman¹,

Ahdout²,

Kim³

2010

Journal of the American Academy of Dermatology

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“…Results showed statistically significant improvement in photodamage ( P < 0.05) and average roughness ( P < 0.001) . Smoothness depth showed improvement but was not statistically significant …”

Section: Vitaminsmentioning

confidence: 91%

“…in a 24‐week split‐face, single‐blind, place‐bocontrolled trial ( n = 29) . Retinyl N‐formyl aspartamate and placebo were applied to separate halves of the face twice daily . Both crows feet areas were analyzed by clinical evaluation, digital photographs, skin replicas, and optical profilometry techniques .…”

Section: Vitaminsmentioning

confidence: 99%

Popular over‐the‐counter cosmeceutical ingredients and their clinical efficacy

2019

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The cosmeceutical market is a vast and rapidly growing global industry with hundreds of new products introduced each year. Patients often turn to cosmeceuticals to address their skin problems since these products are more accessible and affordable than prescription products. Unlike most drugs, cosmeceuticals do not undergo strict safety or efficacy testing by the FDA since they are classified as cosmetics. While the marketed properties of some ingredients are thoroughly researched and supported by clinical studies, not all ingredients have been tested to this standard, with some having only molecular or in vitro evidence and hardly any clinical authentication to support their use. Given these characteristics of the industry, dermatologists need to be familiar with cosmeceuticals in order to provide appropriate recommendations to their patients. The goal of this review was to explain the mechanism of action and evaluate the efficacy of popular cosmeceutical ingredients.

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A newly synthesized photostable retinol derivative (retinyl N-formyl aspartamate) for photodamaged skin: Profilometric evaluation of 24-week study

Cited by 21 publications

References 16 publications

Reversal of Skin Aging with Topical Retinoids

Reversal of Skin Aging with Topical Retinoids

Vitamins and photoaging: Do scientific data support their use?

Popular over‐the‐counter cosmeceutical ingredients and their clinical efficacy

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