Chronic wounds are a major burden to overall healthcare cost and patient morbidity. Chronic wounds affect a large portion of the US, and billions of healthcare dollars are spent in their treatment and management. microRNAs (miRNAs) are small, noncoding double-stranded RNAs that posttranscriptionally downregulate the expression of proteincoding genes. Studies have identified miRNAs involved in all three phases of wound healing including inflammation, proliferation, and remodeling. Some miRNAs have been demonstrated in vitro with primary keratinocyte wound healing model and in vivo with mouse wound healing model through regulation of miRNA expression to affect the wound healing process. This review updates the current miRNAs involved in wound healing and discusses the future therapeutic implications and research directions. V C 2015 IUBMB Life, 67(12): [889][890][891][892][893][894][895][896] 2015

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The cosmeceutical market is a vast and rapidly growing global industry with hundreds of new products introduced each year. Patients often turn to cosmeceuticals to address their skin problems since these products are more accessible and affordable than prescription products. Unlike most drugs, cosmeceuticals do not undergo strict safety or efficacy testing by the FDA since they are classified as cosmetics. While the marketed properties of some ingredients are thoroughly researched and supported by clinical studies, not all ingredients have been tested to this standard, with some having only molecular or in vitro evidence and hardly any clinical authentication to support their use. Given these characteristics of the industry, dermatologists need to be familiar with cosmeceuticals in order to provide appropriate recommendations to their patients. The goal of this review was to explain the mechanism of action and evaluate the efficacy of popular cosmeceutical ingredients.

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Vitamin C is a popular ingredient in over‐the‐counter cosmeceuticals due to its many biological functions in maintaining and improving skin health by treating UV damage, improving discoloration, and boosting collagen production. Several chemically modified derivatives of vitamin C have been developed in an attempt to increase the stability, percutaneous absorption, and overall activity of this ingredient in topical formulations. The goal of this review is to evaluate the differences between vitamin C derivatives that have been designed for cosmeceutical use and their efficacy.

Currently, there is little guidance in the literature on how to advise patients who wear the hijab on hijab‐related dermatoses. This manuscript describes hijab‐related dermatoses and provides culturally sensitive recommendations that can be used in conjunction with standard treatments to provide more holistic care for these patients.

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