A newly identified polysaccharide from Ganoderma atrum attenuates hyperglycemia and hyperlipidemia

Zhu, Ke‐Xue; Nie, Shaoping; Li, Chuan; Lin, Suli; Xing, Mengmeng; Li, Wenjuan; Gong, Deming; Xie, Mingyong

doi:10.1016/j.ijbiomac.2013.03.009

Cited by 89 publications

(29 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A review of the literature shows that polysaccharides derived from plants, such as Pteridium aquilinum (Xu et al, 2009), Ficus carica L. (Yang et al, 2009), Lycium barbarum L. (Lin et al, 2009), and Portulaca oleracea L. ) have remarkable antioxidant activity. Meanwhile, the hypoglycemic effect of polysaccharides from plants, particularly the inhibition of postprandial hyperglycemia, has been highlighted recently (Zhu et al, 2013). Furthermore, their potential inhibitory action against α-glucosidase has been proposed as one of the main mechanisms responsible for this hypoglycemic effect (Wang et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

In vitro antioxidant activity and potential inhibitory action against α-glucosidase of polysaccharides from fruit peel of tea (Camellia sinensis L.)

Wang

et al. 2014

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

Abstract:The conditions for extracting polysaccharides from tea (Camellia sinensis L.) fruit peel (TFPPs) were studied. Three parameters (temperature, time, and liquid/solid ratio) affecting the extraction of TFPP were optimized using response surface methodology (RSM). Under the optimized conditions, the yield of TFPP was predicted to be 4.98%. The physicochemical properties, in vitro antioxidant activities, and inhibitory effects on α-glucosidase of fractionated TFPPs (TFPP-0, TFPP-20, TFPP-40, and TFPP-60) were investigated. We found that the TFPPs were all acid protein-bound heteropolysaccharides, although with different chemical compositions. They had not only remarkable scavenging activity on 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) and reducing activity, but also excellent inhibitory potential against α-glucosidase in vitro. Our results suggest that tea fruit peel could be treated as a potential bioresource for the development of polysaccharide antioxidants.

show abstract

Section: Introductionmentioning

confidence: 99%

In vitro antioxidant activity and potential inhibitory action against α-glucosidase of polysaccharides from fruit peel of tea (Camellia sinensis L.)

Wang

et al. 2014

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

show abstract

“…Instead of streptozotocin-induced diabetic mice (Zhu, Nie, Li, Lin, Xing, Li, et al, 2013), cholesterol and fructose-rich diet was used in the present study. Although the main aim was to induce hyperlipidemic mice, diabetic mice were also obtained.…”

Section: Resultsmentioning

confidence: 99%

Sulfation pattern of fucose branches affects the anti-hyperlipidemic activities of fucosylated chondroitin sulfate

Zhang

et al. 2016

Carbohydrate Polymers

View full text Add to dashboard Cite

Fucosylated chondroitin sulfates (fCSs) are glycosaminoglycans extracted from sea cucumbers, consisting of chondroitin sulfate E (CSE) backbones and sulfated fucose branches. The biological properties of fCSs could be affected by the sulfation pattern of their fucose branches. In the present study, two fCSs were isolated from sea cucumbers Isostichopus badionotus (fCS-Ib) and Pearsonothuria graeffei (fCS-Pg). Their monosaccharide compositions of glucuronic acid (GlcA), N-acetylgalactosamine (GalNAc), fucose (Fuc) and sulfate were at similar molar ratio with 1.0/0.7/0.9/3.1 for fCS-Ib and 1.0/0.8/1.5/2.6 for fCS-Pg. The two fCSs have different sulfation patterns on their fucose branches, fCS-Pg with 3,4-O-disulfation while fCS-Ib with 2,4-O-disulfation. Their antihyperlipidemic effects were compared using a high-fat high-fructose diet (HFFD)-fed C57BL/6J mice model. Both fCS-Ib and fCS-Pg had significant effects on lipid profile improvement, liver protection, blood glucose diminution and hepatic glycogen synthesis. Specifically, fCS-Pg with 3,4-O-disulfation fucose branches was more effective in reduction of blood cholesterol (TC), low density lipoprotein (LDL) and atherogenic index (AI). Our results indicate that both fCSs, especially fCS-Pg, could be used as a potential anti-hyperlipidemic drug.

show abstract

“…Ganoderma lucidum belongs to the family Ganoderma lucidum and is a rarified Chinese herbal medicine [8]. Ganoderma lucidum polysaccharides (GLP) are the major active substances of Ganoderma lucidum and have various biological functions, including antitumor [9], immunomodulation [8,10], antioxidation, and hypolipidemic effects [10]. Studies have shown that GLP can inhibit tumor growth in S180 sarcoma-bearing mice and can increase the proportion of CD4 or CD8 T cell subsets in S180 tumor-bearing mice.…”

Section: Introductionmentioning

confidence: 99%

Ganoderma lucidum Polysaccharide Enhanced the Antitumor Effects of 5-Fluorouracil against Gastric Cancer through Its Upregulation of NKG2D/MICA

Yang

Zhang

Yao

et al. 2019

International Journal of Polymer Science

View full text Add to dashboard Cite

5-Fluorouracil (5-Fu) is one of the frequently used first-line cytotoxic drugs for chemotherapy against gastric cancer. Chemotherapy and immunotherapy are currently the main methods for treating gastric cancer. Immunotherapy can enhance the antitumor effect of chemotherapy drugs at the same time reducing its toxicity. The combination of these two therapies to treat cancer has become a mainstay and has received increasing attention in clinical practice. Ganoderma lucidum polysaccharide (GLP) is isolated from the Ganoderma lucidum fruiting body. Studies have shown that GLP has antitumor effects, where GLP does not directly kill tumors, rather exerting its antitumor function by stimulating immune cells including natural killer (NK) cells and T cells. In this study, the antitumor effect of GLP combined with 5-Fu was studied in vivo. At the same time, the associated mechanism of GLP combined with 5-Fu in gastric cancer cell lines BGC823 and SGC7901 was investigated in vitro. The results showed that GLP could stimulate the killing effect of NK-92 cells on gastric cancer cell lines BGC823 and SGC7901 and synergistically enhance the toxic effects of NK-92 cells on gastric cancer cell lines BGC823 and SGC7901. Moreover, GLP could further promote the activity of NK-92 cells by activating the NK cell activating receptor NKG2D and its downstream DAP10/PI3K/ERK signaling pathway.

show abstract

A newly identified polysaccharide from Ganoderma atrum attenuates hyperglycemia and hyperlipidemia

Cited by 89 publications

References 36 publications

In vitro antioxidant activity and potential inhibitory action against α-glucosidase of polysaccharides from fruit peel of tea (Camellia sinensis L.)

In vitro antioxidant activity and potential inhibitory action against α-glucosidase of polysaccharides from fruit peel of tea (Camellia sinensis L.)

Sulfation pattern of fucose branches affects the anti-hyperlipidemic activities of fucosylated chondroitin sulfate

Ganoderma lucidum Polysaccharide Enhanced the Antitumor Effects of 5-Fluorouracil against Gastric Cancer through Its Upregulation of NKG2D/MICA

Contact Info

Product

Resources

About