In vitro antioxidant activity and potential inhibitory action against α-glucosidase of polysaccharides from fruit peel of tea (Camellia sinensis L.)

Abstract

Abstract:The conditions for extracting polysaccharides from tea (Camellia sinensis L.) fruit peel (TFPPs) were studied. Three parameters (temperature, time, and liquid/solid ratio) affecting the extraction of TFPP were optimized using response surface methodology (RSM). Under the optimized conditions, the yield of TFPP was predicted to be 4.98%. The physicochemical properties, in vitro antioxidant activities, and inhibitory effects on α-glucosidase of fractionated TFPPs (TFPP-0, TFPP-20, TFPP-40, and TFPP-60) were investigated. We found that the TFPPs were all acid protein-bound heteropolysaccharides, although with different chemical compositions. They had not only remarkable scavenging activity on 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) and reducing activity, but also excellent inhibitory potential against α-glucosidase in vitro. Our results suggest that tea fruit peel could be treated as a potential bioresource for the development of polysaccharide antioxidants.

Evaluation of the in vitro α‐glucosidase inhibitory activity of green tea polyphenols and different tea types

“…Theaflavins, a major component in black tea and oolong tea extracts, have been shown to inhibit -glucosidase activity. 20 Polysaccharides also had excellent inhibitory potential against -glucosidase 21 and the polysaccharide contents were in the order of oolong tea > black tea > green tea. 22 Therefore, oolong tea had the best inhibitory potential against -glucosidase.…”

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“…Some of the major catechins present in tea are epigallo catechin (EGC) and epigallo catechin gallate (EGCG) 5 . Hibiscus is also known to have beneficial effects in reducing cardiovascular diseases 6,7 . Hibiscus consists of many phytochemicals, which are known to have these ethnomedicinal properties 8,9 .…”

“…Free radicals are involved in the development of various diseases which include cellular aging, coronary heart disease, mutagenesis, diabetes, carcinogenesis and neurodegeneration 6 . The biological properties of tea and tea polyphenols have an effect in cancer, cardiovascular disease, antioxidant, anti-inflammatory, antiobesity, and neurodegenerative disorders prevention 25,26,27 .…”

“…C-reactive protein 59 , acute phase serum amyloid A protein 54 , cartilage oligomatrix protein (COMP), hyaluronic acid, chondroitin sulphates, keratan sulphates etc., 55,56 are some of the biological markers 57,58 . In this study, Tea is used as one such natural source of antioxidants 60 , anti-inflammatory 61 and anti-arthritic agent that helps in the repair of damage caused due to free radical activity 6 , inflammatory agents and mediators respectively.…”

High-performance size-exclusion chromatography studies on the formation and distribution of polar compounds in camellia seed oil during heating

“…et al, 2014). It is found to have suitable nutritional characteristics and medical values (Salinero et al, 2012;Wang Y.F. et al, 2014), and is sometimes termed as "Oriental olive oil".…”