A new xanthone and a new benzophenone from the roots of Garcinia hombroniana

Salleh, Wan Mohd Nuzul Hakimi Wan; On, Shamsul; Ahmad, Farediah; Sirat, Hasnah Mohd; Taher, Muhammad; Sarker, Satyajit D.; Nahar, Lutfun

doi:10.1016/j.phytol.2019.12.011

Cited by 5 publications

(5 citation statements)

References 23 publications

(21 reference statements)

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“…1 . Among those, 2,3′,4,5′-tetrahydroxy-6-methoxybenzophenone ( 2 ) and garcihombrianone ( 3 ) were first reported from this species while the three known polyprenylated benzophenones—(−)-cycloxanthochymol ( 7 ), isoxanthochymol ( 8 ), and xanthochymol ( 9 ) were isolated for the first time in this species [ 18 , 45 , 31 ].…”

Section: Phytochemical Constituentsmentioning

confidence: 99%

“…Garcinisidone H ( 54 ) was isolated from the ethyl acetate bark extract of G. celebica [ 34 ]. Xanthone 55 – 75 were discovered to be present in G. celebica in many studies [ 14 , 17 , 18 , 30 , 34 , 35 ]. Furthermore, garcihomxanthone ( 63) was isolated from the acetone extract of the root of G. celebica ( Fig.…”

Section: Phytochemical Constituentsmentioning

confidence: 99%

“…Furthermore, garcihomxanthone ( 63) was isolated from the acetone extract of the root of G. celebica ( Fig. 4 and Table 4 ) [ 18 ].…”

Section: Phytochemical Constituentsmentioning

confidence: 99%

“…The phytochemicals present in G. celebica possess substantial pharmacological effects that have been empirically used in traditional medicine for various purposes [ 13 , 14 ]. The decoction of the root of G. celebica was utilized for preventing infections after childbirth in folk medicines, while the root and leaf parts were used as ailments for relieving itchiness and treating skin diseases [ [15] , [16] , [17] , [18] ].…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical profile and diverse pharmacology of Garcinia celebica L

Mustafa,

Jalil,

Leong

et al. 2024

Heliyon

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Section: Phytochemical Constituentsmentioning

confidence: 99%

Section: Phytochemical Constituentsmentioning

confidence: 99%

“…Furthermore, garcihomxanthone ( 63) was isolated from the acetone extract of the root of G. celebica ( Fig. 4 and Table 4 ) [ 18 ].…”

Section: Phytochemical Constituentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Phytochemical profile and diverse pharmacology of Garcinia celebica L

Mustafa,

Jalil,

Leong

et al. 2024

Heliyon

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“…A halogenated benzophenone 226 was discovered in an extract of A. flavipes PJ03-11 [142], while 227 and 228 were found in A. terreus Thom [143] and A. wentii [144], respectively. Garcihombrianone 229, which was found in the roots of Garcinia hombroniana Pierre [145], can be viewed as two benzophenone molecules sharing a common benzene nucleus. Three benzophenone-xanthone dimers 230-232 were isolated from roots of G. dulcis (Roxb.)…”

Section: Uncategorized and Miscellaneous Benzophenonesmentioning

confidence: 99%

Naturally Occurring Simple Oxygenated Benzophenones: Structural Diversity, Distribution, and Biological Properties

Marinov,

Kokanova-Nedialkova,

Nedialkov

2023

Diversity

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Naturally occurring benzophenones represent a relatively small group of plant metabolites with narrow distribution, mainly in members of Clusiaceae, Gentianaceae, Hypericaceae, Polygalaceae, Myrtaceae, etc.; however, there were reports of several compounds derived from microorganisms belonging to the Aspergillaceae and Valsaceae families and propolis. Benzophenones exhibit many biological activities, such as antioxidant, anti-inflammatory, cytotoxic, antimicrobial, etc. Few reviews on benzophenones that have appeared in the literature were focused on their prenylated derivatives. Summarized information on structural diversity, distribution, and biological activities of simple oxygenated naturally occurring benzophenones and their glycosides has not been found in the literature. Until 2000, only benzophenone C-glycosides were known to occur in nature. Since then, many O-glycosides have been isolated, structurally, and biologically characterized. This review covers the years from 1850 to 2023 and was compiled using databases such as Chemical Abstracts, Scopus, Google Scholar, PubMed, and ResearchGate. Based on their degree of oxidation, 210 chemical structures of benzophenone derivatives and glycosides were grouped into six categories. In addition, in one group of 40 miscellaneous benzophenones, where one or several protons are replaced by a methyl, alcohol, carboxyl, or acyl group, glycosidic forms with such an aglycone and dimeric compounds with xanthone was included. Simple oxygenated benzophenones and their glycosides were found in 77 plant genera belonging to 44 families. The allergy-associated bezophenone-1, benzophenone-2 and benzophenone-3 have limited distribution across natural sources. A wide range of biological activities (antioxidant, anti-inflammatory, cytotoxic, antitumor, cytoprotective, antimicrobial, MAO-A, antiarthritic, anticholinesterase, anti-atherosclerotic, laxative, etc.) of simple oxygenated benzophenones and their glycosides that appeared in the literature were discussed.

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