A new water-soluble ligand for efficient copper-catalyzed Huisgen cycloaddition of aliphatic azides and alkynes

Fluorescent 1,2,3-triazole derivative of 3′-deoxy-3-azidothymidine: synthesis and absorption/emission spectra

“…trans-2-Azidocyclohexanol and benzyl azide were prepared using literature procedures, from cyclohexene oxide [16] and benzyl bromide [17], respectively. AMTC (the catalytic ligand for copper-catalyzed azide-alkyne cycloaddition), was prepared according to a procedure developed by our group [15].…”

“…The synthesis of a novel alkyne-containing fluorescent probe, 9H-fluoren-9-ylmethyl prop-2-yn-1-yl carbonate (propargyl-fmoc) and its copper-catalyzed cycloaddition reactions with two model azides, trans-2-azidocyclohexanol, and benzyl azide, are also described. For these reactions, a ligand-assisted protocol, using 2-{4-[(dimethylamino) methyl]-1,2,3-triazol-1-yl}cyclohexan-1-ol (AMTC) as a copper-stabilizing ligand, developed in our research group, was applied [15] and additional solvent composition studies were performed to develop an efficient cycloaddition procedure for propargyl-fmoc (1) and zidovudine. 9H-Fluoren-9-ylmethyl prop-2-yn-1-yl carbonate ( propargyl-fmoc, 1) was efficiently prepared from fmocchloride and propargyl alcohol (Scheme 1).…”

“…A ligand-assisted cycloaddition protocol, developed in our laboratory [15], with a high copper loading (10 mol%) and long reaction time to ensure high conversion was used. The general procedure is given below.…”

Spinel copper ferrite nanoparticles: Preparation, characterization and catalytic activity

“…5 mg of catalyst was chosen as the best amount of catalyst according to high yield. We have also investigated the catalytic performances of the catalyst in various solvents such as toluene, CH 3 [4][5][6][7][8]. Therefore, propanol was utilized as the best solvent.…”

“…1,3-cycloaddition reactions of terminal azides with monosubstituted alkynes as well as three component coupling reaction of aldehyde, alkyne and amine to respectively form a wide range of 1,2,3-triazoles and propargylamines are among the most crucial synthetic transformations in chemistry. [1][2][3][4][5] This reaction has arguably become one of the most powerful synthetic methods to prepare a wide range of 1,2,3-triazoles and propargylamines as heterocyclic molecules, which can then serve as building blocks and/or intermediates for various drugs, energetic binders, pharmaceuticals, and biodegradable polymers. [6][7][8][9][10] One of the most active research areas in nanoscience, nanotechnology and advanced materials is the synthesis of functional magnetic nanoparticles (MNPs) which can easily be separated and recycled from the reaction solutions by an external magnet.…”