A new translocation in chronic myelogenous leukemia

Abstract

A reciprocal translocation involving chromosomes Nos. 3 and 22 has been found in a patient with seemingly Ph-negative chronic myelogenous leukemia (CML). G-band analysis revealed, that deletion in No. 22 occurred at the same point, as in the typical cases of the disease. It was concluded, that breakage in No. 22 at a specific site with spatial disjunction of the resulting segments might be the crucial cytogenetic event in the genesis of CML, the Philadelphia chromosome not being an obligatory result of the rearrangement.

Hematopoietic engraftment following transplantation of bone marrow cells carrying a Philadelphia (Ph′)‐like chromosome

“…The minute chromosome produced by these changes, the Philadelphia chromosome (Ph', 22q--) is associated \\;Ih typical chronic myelocytic leukemia (CMl) (1,2). While the Ph' chromosome in Oil frequently represents a reciprocal translocation Involving chromosome 9, t(22q II) (3)(4)(5), translocations with other chromosomes have also been observed (6)(7)(8).…”

The value of reverse banding in detecting bone marrow chromosomal abnormalities: Translocation between chromosomes 1, 9, and 22 in a case of chronic myelogenous leukemia (CML)

“…Employing GTG (G-bands by trypsin using Giemsa) and QFQ (Q·bands by fluorescence using Quinacrine), Rowley and others have demonstrated that the deleted part of the long ann of chromosome 22 is translocated onto the long arm of chromosome 9 (3)(4)(5). Trans-locations on chromosomes 2,3,6,17,19, and 22 have also been reported (6)(7)(8)(9). The presence or absence of the Phi chromosome has important diagnostic and prognostic value.…”