Atypical chronic myelogenous leukemia with Philadelphia (PH') chromosome and an additional translocation

Norman, C. S.; Boucher, Barbara J

doi:10.1002/1097-0142(197803)41:3<1123::aid-cncr2820410347>3.0.co;2-9

Cited by 11 publications

(1 citation statement)

References 16 publications

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“…comm. MISAWA 1978MIYOSHI et al 1976USA CASTLEMAN et al 1973COMO and GRAZE 1979GALL et al 1976GREENBERG et al 1978HAYATA et al 1975KAFFE et al 1974KOHNOet al 1979NORMAN and BOUCHER 1978NOWELL et al 1975ROWLEY 1975bSONlA and SANDBERG 1977bSTERN et al 1979aWHANG-PENG et al 1973 extra Phl chromosome in 90.1 %. Altogether, at least I of the 3 changes-+& iso(l7q) and +Ph'-occurred in 289 of the 361 cases (80.1 %).…”

Section: Jotterandmentioning

confidence: 99%

Clustering of aberrations to specific chromosomes in human neoplasms

2009

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This survey of chromosomal aberrations in human neoplasms comprises 1,871 cases distributed on 15 groups of malignant disease, viz. 4 groups of myeloproliferative disorders with 1,328 cases, 5 groups of lymphoproliferative disorders with 369 cases and 6 groups of solid tumors with 174 cases. The material is presented in 17 tables, in which the variation of each chromosome is listed separately for each geographic region. In the discussion part a number of special problems are looked into. The difference in variation between the individual chromosomes was highly signifcant statistically. Within each tumor, all chromosomes which exceeded the average variation with more than 1 standard deviation were considered selectively involved. In all neoplasms taken together, the chromosomes selectively involved clustered to 15 of the 24 human chromosome types. Other topics taken up for discussion were the following: possible differences in chromosome variation between geographic regions; the specificity of certain marker chromosomes; the hypothesis of 2 essentially different kinds of chromosome aberration in cancer. The phenomena of genic amplification and recurrent translocation often found in cancer require the assumption of unorthodox cytogenetic mechanisms. One main conclusion of the paper is that the aberrations of the selectively involved chromosomes influence cancer development because of the genes they carry.

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Section: Jotterandmentioning

confidence: 99%

Clustering of aberrations to specific chromosomes in human neoplasms

2009

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Chromosome 1 in 26 carcinomas of the cervix uteriStructural and numerical changes

Atkin

Baker

1979

Cancer

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Cytogenetic studies on 26 carcinomas of the cervix showed that chromosome 1 was consistently involved in the changes: either one or more structurally abnormal chromosomes or a relative excess of normal chromosomes were present. Several types of structural change were repeatedly seen: short arm deletions (lp-, in seven tumors); long arm isochromosomes (i(lq), in six tumors); and translocations of unidentified chromosomal material onto one of the arms (possibly in eleven tumors; in four of these, there was an additional C-band on the long arm). In one tumor, there was a short arm isochromosome (i(1p)). The most consistent feature of the aneuploid complements of these tumors appeared to be the presence in excess of the centromeric region and at least part of the adjacent heterochromatin of chromosome 1.Cancer 44:604-613, 1979.NUMBER OF chromosome studies of car-A cinoma of the cervix were made before the introduction of banding technique^,'"^ but no systematic studies using these new procedures have yet been reported. We describe here our findings on 24 tumors that showed reasonably good G-, C-or Q-banding, and two in which identification of the chromosomes 1 were reasonably certain in orcein-stained preparations. Since abnormalities involving chromosome 1 were relatively easy to observe, and since such abnormalities appeared to be common in other types of malignant disease (as discussed later), particular attention has been paid to this chromosome pair. MATERIALS A N D METHODSThe tumors represent those that yielded the most favorable preparations and comprise 18 from a series of 37 received over a recent 12-month period and eight from the previous three years. Accepted for publication September 7, 1978. Brief clinical and pathologic details of the cases are shown in Table 1. Cytogenetic studies were made on uncultured biopsy specimens of the untreated primary tumors, except Case 23 which was of a vaginal recurrence following surgery. The material was converted into a cell suspension using scalpels and scissors, and the cells exposed consecutively to 2 pg/ml Colcemid and 0.04% versene, both in Earle's solution for 30 minutes at 37 C , followed by hypotonic treatment, calf serum/ 0 . 0 5 2~ KCl (1:4), for 15 minutes at 37 C. Treatment with versene aids the production of a suspension. The material was fixed in acetic acid/methanol (3:7) and slides were made by the air-drying method. The following banding techniques were used-G-banding: acetic-saline-Giemsa, trypsin, or a combination of the the latter producing the most favorable results; C-banding: BSG technique; l4 Q-banding: quinacrine dihydrochloride. N o banding procedure was used on Case 4, but the heterochromatic regions of the chromosomes 1 were distinguishable as secondary constrictions (and as darkly-staining regions in Case 2) in orcein-stained preparations. RESULTSAs is evident from Table 1, the cases can be divided into two groups as regards modal chromosome number: a near-diploid group (Cases 1 -15) with modes varying from 40 to about 5 1, and a high-...

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Chromosomes and causation of human cancer and leukemia: XL. The Ph1 and other translocations in CML

Sandberg

1980

Cancer

118

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To date, 85 cases with unusual Ph1 translocations have been described and are summarized in the present work. Of the 85 translocations, 41 were simple and 44 complex. Only chromosomes #1, #4, #8, and #20 and the Y have not been found to be involved in simple translocations and #12, #16, #18, #20 and the Y in complex ones. Chromosomes #18, #20, and Y have not been involved to date in either complex or simple Ph1 translocations. Four cases have been reported in whom more tan three chromosomes were involved in the Ph1 translocation and only four cases in whom the #9 was not involved in complex Ph1 translocations. The chromosomal changes, in addition to the Ph1, accompanying unusual Ph1 translocations in CML are not different from those seen in cases with the standard type of Ph1 translocation. Translocations (other than the Ph1) in CML occur in less than 1% of the cases and, to date, have found to involve all the chromosomes except the X and Y. With rare exceptions, in complex Ph1 translocations 1) the distal end of #22 is translocated to a third chromosome (i.e., other than #9), a part of which is translocated to #9, #2) the breaks in the involved chromosomes probably occur concomitantly, and 3) a characteristic PH1 chromosome is present. The survival of patients with CML and unusual or complex Ph1 translocations does not differ significantly from that of patients with the standard Ph1-translocation.

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Atypical chronic myelogenous leukemia with Philadelphia (PH') chromosome and an additional translocation

Cited by 11 publications

References 16 publications

Clustering of aberrations to specific chromosomes in human neoplasms

Clustering of aberrations to specific chromosomes in human neoplasms

Chromosome 1 in 26 carcinomas of the cervix uteriStructural and numerical changes

Chromosomes and causation of human cancer and leukemia: XL. The Ph1 and other translocations in CML

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