A New Three-Carbon Synthon for Efficient Synthesis of Benzannelated and 1-(2-Arylethenyl) Heterocycles

Abstract

The novel three-carbon synthon 1-(1H-1,2, 3-benzotriazol-1-yl)-3-chloroacetone for the synthesis of benzothiazoles, pyrido[1,2-a]indoles, and styryl-substituted indolizines and imidazo[1,2-a]pyridines is reported. The proposed routes are a general and efficient approach for heterocyclizations followed by benzannelations or attachment of arylethenyl pharmacophores.

Efficient three-component synthesis of N-alkyl-3,6-diaryl-[1,2,4]triazolo[4,3-b][1,2,4]triazin-7-amines under solvent-free condition

“…These N-fused polycycles displayed a wide range of biological activities such as anticancer, antibacterial, antifungal, antiplasmodial, antineoplastic and DNA intercalators. [12][13][14][15][16] For instance, diverse compounds derived from 1,2,4-triazoles are well known as antibacterial, antifungal, antiviral, antiinflammatory, antihypertensive, and hypoglycemic agents. [17][18][19][20][21][22][23] They also show herbicidal and antimicrobial activities making them a popular target for new drug development.…”

Antidepressant, Analgesic Activity and SAR Studies of Substituted Benzimidazoles

“…In the past years, there has been substantial interest in the development and pharmacological activity of organic compounds possessing hetero aromatic moiety in its structure, such as benzimidazole [1,2]. Structurally, benzimidazole core contains two aromatic Nheterocycles that can bind to enzymes or receptors via hydrogen bonds coordinated with metal ions or hydrophobic interactions [3].…”

Convenient Approach for the One-Pot, Three-Component Synthesis of 1-(Benzothiazolylamino)Methyl-2- Naphthol Using Citric Acid as a Green Catalyst

“…10,11 2-AminoBenzothiazoles as inimitable frames are presented a broad spectrum of pharmacological and biological properties. 12 Simplicity in electron transfer in the firefly luciferine cycle is reason of their different acts, 13 through antitumor, 14 and antidiabetic activity 15 to Alzheimer disease tracer, 16 and anticancer agent in pharmaceutical chemistry. 17 Also, benzothiazoles are commercially momentous as reactive dyes, 18 hair dyes, 19 agrochemical fungicides, acaricides, herbicides, insecticides, plant desiccants, and defolicants.…”