A new therapeutic approach for carbon monoxide poisoning: Antioxidants

Akyol, Sümeyya; Güleç, Mehmet Akif; Erdemli, Hacı Kemal; Akyol, Ömer

doi:10.1016/j.tox.2015.07.011

Cited by 9 publications

(3 citation statements)

References 9 publications

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“… 16 The mechanism of CO toxicity is not clear; however, if it results in oxidative stress, neuronal toxicity, and post ischemic reperfusion injury responsible for delayed symptoms, antioxidants may prove to be a novel treatment approach. 17 , 18 , 19 …”

Section: Discussionmentioning

confidence: 99%

Delayed neurologic sequelae of carbon monoxide intoxication

Sönmez

İşcanlı

Parlak

et al. 2018

Turkish Journal of Emergency Medicine

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Altered consciousness and accompanying neurological symptoms are both complex and challenging cases for emergency physicians. These are not specific and may be a sign of a variety of medical conditions including stroke and delayed neurological sequelae (DNS) is a recurrent transient neuropsychiatric consequence of CO intoxication. DNS produces a spectrum of varying symptoms and the diagnosis is primarily made on the basis of clinical features and radiological findings from CT and conventional MRI. In clinical practice, serious CO intoxication is treated only with oxygen therapy although no effective treatment exists. Emergency physicians play a major role in managing patients presenting with CO intoxication and preventing DNS.

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Section: Discussionmentioning

confidence: 99%

Delayed neurologic sequelae of carbon monoxide intoxication

Sönmez

İşcanlı

Parlak

et al. 2018

Turkish Journal of Emergency Medicine

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“…Particularly, measuring of free radicals resultant of tissue hypoxia, ischemia and/or mediators which are released in case of perfusion recently became an intriguing subject; these are considered to assume an assistive role in determination of poisoning level (18).…”

Section: Study Populationmentioning

confidence: 99%

Evaluation of Systemic Inflammatory Parameters in Carbon Monoxide Poisoning

Emektar

Dağar

Çorbacıoğlu

et al. 2019

Kırıkkale Üniversitesi Tıp Fakültesi Dergisi

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Objective: The objective of this study is to examine systemic inflammatory blood parameters measured in complete blood count of patients with carbon monoxide (CO) poisoning and to evaluate the relation between the parameters and the severity of poisoning. Material and Methods: Our study is a retrospective case control study. Data was obtained through hospital automation system. Patients who were detected to have 10% and above carboxyhemoglobin levels were included in the study. Patients' complete blood count parameters, red cell distribution width (RDW), neutrophil/lymphocyte ratios (NLR), platelet/lymphocyte ratios (PLR) and treatments were recorded. Results: When the control group was compared to patient group, WBC, leukocyte, neutrophil, platelet, NLR and PLR values were higher in the patient group and these differences were statistically significant (p <0.05). Patients were split into two groups in accordance with the severity of their poisoning. No significant differences were observed in terms of laboratory results (p >0.05). Conclusion: In patients with CO poisoning, values of NLO, PLO and RDW indicate inflammation. We consider that these values do not assume a role in determination of poisoning severity and in shaping of the treatment to be administered. Amaç: Bu çalışmada karbonmonoksit (CO) zehirlenmesi olan hastalarda tam kan sayımında bakılan sistemik inflamatuvar kan parametrelerinin irdelenmesi ve bu parametreler ile zehirlenme ciddiyeti arasındaki ilişkinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntemler: Çalışmamız retrospektif vaka kontrol çalışmasıdır. Veriler hastane otomasyon sisteminden elde edildi. Karboksihemoglobin düzeyi %10 ve üzerinde saptanan hastalar çalışmaya dahil edildi. Hastaların tam kan sayımı parametreleri, kırmızı küre dağılım genişliği (RDW), nötrofil/lenfosit oranı (NLO), platelet/lenfosit oranı (PLO) ve tedavileri kaydedildi. Bulgular: Hasta grubunda kontrol grubu ile karşılaştırıldığında WBC, lökosit, nötrofil, trombosit, NLO ve PLO değerleri daha yüksekti ve bu farklar, istatistiksel olarak anlamlıydı (p <0.05). Hastalar zehirlenme ciddiyetlerine göre iki gruba ayrıldı, gruplar arasında laboratuar sonuçları açısından anlamlı fark saptanmadı (p>0.05) Sonuç: NLO, PLO, RDW; CO zehirlenmesi olan hastalarda, inflamasyonu göstermekte olup, zehirlenme ciddiyetini belirlemede ve tedaviyi şekillendirme de rolü olmadığını düşünmekteyiz.

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“…2,3,5 On the other hand, there are few studies that HBO treatment may lead to an increase in the amount of dissolved oxygen and ROS, which can cause cellular damage with lipid, protein, and DNA oxidation. [6][7][8] But these effects remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of oxidative stress and antioxidant parameters in children with carbon monoxide poisoning

et al. 2019

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Objective: In this study, we aimed to investigate oxidative stress and antioxidant parameter levels in patients with carbon monoxide (CO) poisoning. Methods: The study was conducted prospectively between March 1, 2015 and April 30, 2016 in the pediatric emergency department. Eligible patients included children aged 0–18 years old with a diagnosis of CO poisoning. To determination of oxidative stress and antioxidant parameter levels, venous blood with heparinized and urine samples were drawn during the admission and after normobaric oxygen (NBO) and hyperbaric oxygen (HBO) treatment. Results: Forty-seven children with CO poisoning for study group and 29 patients as control group were included to the study. Sixteen patients treated with HBO. Basal plasma malondialdehyde levels were found to be significantly higher in the CO poisoning group when compared with the control group ( p = 0.019). There is no significant difference in oxidative stress and antioxidant parameter levels except erythrocyte catalase enzyme levels in patients treated with NBO when comparing before and after NBO treatment ( p > 0.05). Decreasing of basal erythrocyte catalase enzyme levels were found statistically significant after NBO treatment ( p = 0.04). There was no significant difference in oxidative stress and antioxidant parameter levels in patients treated with HBO before and after therapy ( p > 0.05). Conclusions: CO poisoning is associated with increased lipid peroxidation in children immediately after the poisoning. However, both treatment modalities including NBO or HBO do not have a significant effect on oxidative stress or antioxidant parameter levels.

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A new therapeutic approach for carbon monoxide poisoning: Antioxidants

Cited by 9 publications

References 9 publications

Delayed neurologic sequelae of carbon monoxide intoxication

Delayed neurologic sequelae of carbon monoxide intoxication

Evaluation of Systemic Inflammatory Parameters in Carbon Monoxide Poisoning

Evaluation of oxidative stress and antioxidant parameters in children with carbon monoxide poisoning

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