Evaluation of Systemic Inflammatory Parameters in Carbon Monoxide Poisoning

Abstract

Objective: The objective of this study is to examine systemic inflammatory blood parameters measured in complete blood count of patients with carbon monoxide (CO) poisoning and to evaluate the relation between the parameters and the severity of poisoning. Material and Methods: Our study is a retrospective case control study. Data was obtained through hospital automation system. Patients who were detected to have 10% and above carboxyhemoglobin levels were included in the study. Patients' complete blood count parameters, red cell distribution width (RDW), neutrophil/lymphocyte ratios (NLR), platelet/lymphocyte ratios (PLR) and treatments were recorded. Results: When the control group was compared to patient group, WBC, leukocyte, neutrophil, platelet, NLR and PLR values were higher in the patient group and these differences were statistically significant (p <0.05). Patients were split into two groups in accordance with the severity of their poisoning. No significant differences were observed in terms of laboratory results (p >0.05). Conclusion: In patients with CO poisoning, values of NLO, PLO and RDW indicate inflammation. We consider that these values do not assume a role in determination of poisoning severity and in shaping of the treatment to be administered. Amaç: Bu çalışmada karbonmonoksit (CO) zehirlenmesi olan hastalarda tam kan sayımında bakılan sistemik inflamatuvar kan parametrelerinin irdelenmesi ve bu parametreler ile zehirlenme ciddiyeti arasındaki ilişkinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntemler: Çalışmamız retrospektif vaka kontrol çalışmasıdır. Veriler hastane otomasyon sisteminden elde edildi. Karboksihemoglobin düzeyi %10 ve üzerinde saptanan hastalar çalışmaya dahil edildi. Hastaların tam kan sayımı parametreleri, kırmızı küre dağılım genişliği (RDW), nötrofil/lenfosit oranı (NLO), platelet/lenfosit oranı (PLO) ve tedavileri kaydedildi. Bulgular: Hasta grubunda kontrol grubu ile karşılaştırıldığında WBC, lökosit, nötrofil, trombosit, NLO ve PLO değerleri daha yüksekti ve bu farklar, istatistiksel olarak anlamlıydı (p <0.05). Hastalar zehirlenme ciddiyetlerine göre iki gruba ayrıldı, gruplar arasında laboratuar sonuçları açısından anlamlı fark saptanmadı (p>0.05) Sonuç: NLO, PLO, RDW; CO zehirlenmesi olan hastalarda, inflamasyonu göstermekte olup, zehirlenme ciddiyetini belirlemede ve tedaviyi şekillendirme de rolü olmadığını düşünmekteyiz.

Clinical and Laboratory Characteristics Predicting the Severity of Carbon Monoxide Poisoning in Children

“…Leukocytes have been shown in previous adult studies to cause tissue injury connected with CO intoxication. 36 White blood cell, LYM, NEU, and NLR levels of COP cases were significantly higher compared with the control group, according to Tursun et al, Ertekin et al, and Emektar et al, [37][38][39] but no statistically significant correlation was found between the severity of COP and these parameters. Coşkun et al 18 discovered that circulating leukocyte, NEU, and LYM levels were significantly greater in adults with severe CO intoxication than in those with mild to moderate CO intoxication, implying that these elevated concentrations in the acute period were positively associated with high mortality in the short and long term.…”