2011
DOI: 10.3109/17435390.2011.629748
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A new strategy to investigate the toxicity of nanomaterials using Langmuir monolayers as membrane models

Abstract: Nanomaterials such as carbon nanotubes (CNTs) and nanoparticles have received enormous attention in analytical areas for their potential applications as new tools for biotechnology and life sciences. Most of these possible applications involve the use of CNTs and related materials as vehicles for drug delivery and/or gene therapy. In this study, we introduce a methodology to evaluate the interactions between CNTs/dendrimers nanoconjugates and phospholipid biomembrane models, using the Langmuir film balance tec… Show more

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Cited by 34 publications
(21 citation statements)
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“…Moreover, in the presence of SWCNTs-DNR conjugates the isotherms are only slightly shifted towards larger areas per molecule but their shape is not altered. Similar observation was made by Cancino et al, who studied the effect of carbon nanotubes-dendrimers nanoconjugates on DPPC monolayers [29]. The presence of such types of adducts did not significantly affect the properties of lipid monolayers.…”
Section: Resultssupporting
confidence: 81%
“…Moreover, in the presence of SWCNTs-DNR conjugates the isotherms are only slightly shifted towards larger areas per molecule but their shape is not altered. Similar observation was made by Cancino et al, who studied the effect of carbon nanotubes-dendrimers nanoconjugates on DPPC monolayers [29]. The presence of such types of adducts did not significantly affect the properties of lipid monolayers.…”
Section: Resultssupporting
confidence: 81%
“…Cancino et al [104] investigated the interactions between PC monolayers and G2 PAMAM dendrimers, single walled carbon nanotubes (SWCNT) and dendrimer-SWCNT conjugates (G2, G4, G6). The surface pressure of the monolayer was recorded as a function of molecular area (π-A) alongside BAM observations and dilatational surface elasticity measurements.…”
Section: Interactions Between Pamam Dendrimers and Langmuir Monolayersmentioning
confidence: 99%
“…For example nanoconjugates of singlewalled CNTs and dendrimers have been shown to penetrate DPPC monolayers [275]. Using film balance studies with surface pressure and surface potential measurements, BAM and AFM, Yang et al showed that Dy@C82 (a type of metallofullerene with stronger electron acceptors and electron donors than C60) has a higher impact on the physical properties of DPPC monolayers than C60 due to its elliptical structure and distinctive dipole [276].…”
Section: Accepted Manuscriptmentioning
confidence: 98%