A new standardized phytoextract from red orange and lemon wastes (red orange and lemon extract) reduces basophil degranulation and activation

Caruso, Massimo; Fabroni, Simona; Emma, Rosalia; Ballistreri, Gabriele; Amenta, Margherita; Currenti, Walter; Rinzivillo, Calogero; Rapisarda, Paolo

doi:10.1080/14786419.2020.1761355

Cited by 14 publications

(13 citation statements)

References 18 publications

(4 reference statements)

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“…The standardized extract was created at CREA—Research Centre for Olive, Fruit and Citrus Crops (CREA-OFA, Acireale, Italy), for research purposes only. Further information about the identification and relative concentrations of individual flavanones and anthocyanins are already described in previous studies, and performed by HPLC-PDA-ESI/MS n analysis [ 18 , 20 ]. The chemical composition of RLE is shown in Table 1 .…”

Section: Methodsmentioning

confidence: 99%

Productive Performance and Meat Characteristics of Kids Fed a Red Orange and Lemon Extract

Salzano

Damiano

D’Angelo

et al. 2021

Animals

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This study evaluates the animal performance and meat characteristics of 60 Saanen suckling kids daily fed a red orange and lemon extract (RLE), rich in anthocyanins. In our methodology, after colostrum administration, animals are randomly assigned to two treatments: Treatment group (Group RLE; n = 30) that received RLE (90 mg/kg live body weight) as oral food additive, and a control group (Group CON; n = 30) that received a standard diet. Animals are slaughtered after 40 days. The RLE administration did not influence daily weight gain, carcass measurements, or incidences (expressed as a percentage) of different anatomical regions on the whole carcass weight. On the contrary, RLE supplementation significantly improved the oxidative profile of the meat seven days after slaughtering, as demonstrated by the reduced levels of thiobarbituric acid reactive substances (TBARS; p < 0.01) and hydroperoxides (p < 0.01) in Group RLE compared to Group CON. A significant influence of RLE administration is observed on day 7 for yellowness (p < 0.01). There are also lower saturated and higher monounsaturated and polyunsaturated fatty acids concentration in Group RLE meat (p < 0.01), which also shows lower atherogenic and thrombogenic indexes (p < 0.01) compared to Group CON. The study demonstrates that the supplementation of a diet with RLE rich in anthocyanins is effective to improve the meat quality.

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Section: Methodsmentioning

confidence: 99%

Productive Performance and Meat Characteristics of Kids Fed a Red Orange and Lemon Extract

Salzano

Damiano

D’Angelo

et al. 2021

Animals

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“…Several pharmacological studies suggested that C. limetta peel is an important source of bioactive flavonoids, glucosides, and vitamins (Romero-Lopez, Osorio-Diaz, Bello-Perez, Tovar, & Bernardino-Nicanor, 2011). Interestingly, C. limetta fruit peels possess antiviral potential (Choudhary, Kumar, Dalal, Tomar, & Reddy, 2020), anti-allergic by reducing the basophil degranulation (Caruso et al, 2020), nano crystalline cellulose isolated from peels as drug delivery excipient for sustained release of nonsteroidal anti-inflammatory drugs (Gupta & Raghav, 2020), reduce the skin inflammation (Maurya, Mohanty, Pal, Chanotiya, & Bawankule, 2018), antidiabetic potential (Flores-Fernandez, Barragán-Alvarez, Diaz-Martínez, Villanueva-Rodríguez, & Padilla-Camberos, 2017), antibacterial (Damian-Reyna, González-Hernández, Maya-Yescas, de Jesús Cortés-Penagos, & del Carmen Chávez-Parga, 2017, attenuate the severe malaria pathogenesis by inhibiting the production of pro-inflammatory markers (Mohanty et al, 2015), and beneficial for the management of metabolic syndrome (Alam et al, 2014).…”

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Hesperidin‐rich ethanol extract from waste peels of Citrus limetta mitigates rheumatoid arthritis and related complications

Babu

Binwal

Ranjana

et al. 2021

Phytotherapy Research

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The aim of this study is to explore the possible pharmacological effects of fruit waste that may have a key role in converting the fruit waste into pharmaceutical agents. Citrus limetta (Rutaceae) is an important commercial citrus fruit crops used by juice processing industries. C. limetta peels are perishable waste material, which creates a big challenge in juice processing industries. Initial pharmaco‐chemical profile of peels' extracts revealed that the ethanol extract (ClPs) has promising anti‐inflammatory activity and rich in hesperidin content. In vivo experimental pharmacology profile of ClPs against arthritis and related complications revealed that oral administration of ClPs significantly reduced the arthritis score and arthritis index in elbow and knee joints against collagen‐induced arthritis (CIA) in rats. Biochemical parameters include pro‐inflammatory cytokines (TNF‐α, IL‐6, and IL‐17A), and C‐RP level in blood serum of CIA rats further confirmed the anti‐arthritic profile of ClPs. Further individual experiments related to arthritis‐related complications in experimental animals demonstrated the analgesic, anti‐inflammatory, and antipyretic potential of ClPs in dose‐dependent manner. The result of this study suggests the suitability of ClPs as a drug‐like candidate for further investigation toward the management of arthritis and related complications.

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“…Indeed, it has been previously demonstrated that RLE is active in reducing basophil degranulation and activation [ 14 ] and in preventing renal damage induced by diabetic nephropathy [ 15 , 16 ] or ocratoxin ingestion [ 17 ]. Moreover, RLE has been previously tested as an oral additive for goat kids, showing ameliorated juiciness and reduced color deterioration of the kids’ meat as a result of delayed lipid oxidation.…”

Section: Discussionmentioning

confidence: 99%

A Standardized Extract Prepared from Red Orange and Lemon Wastes Blocks High-Fat Diet-Induced Hyperglycemia and Hyperlipidemia in Mice

et al. 2021

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Citrus fruits are a rich source of high-value bioactive compounds and their consumption has been associated with beneficial effects on human health. Red (blood) oranges (Citrus sinensis L. Osbeck) are particularly rich in anthocyanins (95% of which are represented by cyanidin-3-glucoside and cyanidin-3-6″-malonyl-glucoside), flavanones (hesperidin, narirutin, and didymin), and hydroxycinnamic acids (caffeic acid, coumaric acid, sinapic, and ferulic acid). Lemon fruit (Citrus limon) is also rich in flavanones (eriocitrin, hesperidin, and diosmin) and other polyphenols. All of these compounds are believed to play a very important role as dietary antioxidants due to their ability to scavenge free radicals. A standardized powder extract, red orange and lemon extract (RLE), was obtained by properly mixing anthocyanins and other polyphenols recovered from red orange processing waste with eriocitrin and other flavanones recovered from lemon peel by a patented extraction process. RLE was used for in vivo assays aimed at testing a potential beneficial effect on glucose and lipid metabolism. In vivo experiments performed on male CD1 mice fed with a high-fat diet showed that an 8-week treatment with RLE was able to induce a significant reduction in glucose, cholesterol and triglycerides levels in the blood, with positive effects on regulation of hyperglycemia and lipid metabolism, thus suggesting a potential use of this new phytoextract for nutraceutical purposes.

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A new standardized phytoextract from red orange and lemon wastes (red orange and lemon extract) reduces basophil degranulation and activation

Abstract: A new standardized phytoextract from red orange and lemon wastes (Red orange and Lemon Extract) reduces basophil activation and degranulation.

Cited by 14 publications

References 18 publications

Productive Performance and Meat Characteristics of Kids Fed a Red Orange and Lemon Extract

Productive Performance and Meat Characteristics of Kids Fed a Red Orange and Lemon Extract

Hesperidin‐rich ethanol extract from waste peels of Citrus limetta mitigates rheumatoid arthritis and related complications

A Standardized Extract Prepared from Red Orange and Lemon Wastes Blocks High-Fat Diet-Induced Hyperglycemia and Hyperlipidemia in Mice

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