A new spectrophotometric method for quantitative multicomponent analysis resolution of mixtures of salicylic and salicyluric acids

Salinas, F.; Nevado, J. J. Berzas; Espínosa-Mansilla, A.

doi:10.1016/0039-9140(90)80065-n

Cited by 328 publications

(108 citation statements)

References 8 publications

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“…Also, the overlap between SFV and LDI was resolved by applying the first derivative of ratio spectra ( 1 DD) method (Figures 4 and 5). This method is based on the derivatization of the ratio spectra to resolve the binary mixtures [16]. The major advantages of such method are the ability to measure peak amplitudes that has a wonderful effect on the sensitivity of the assay.…”

Section: Resultsmentioning

confidence: 99%

Validated simultaneous spectrophotometric quantification of a new antiviral combination

Abdel-Gawad

2017

Eur. J. Chem.

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Simple, selective and precise spectrophotometric methods were applied for simultaneous quantification of sofosbuvir (SFV) and ledipasvir (LDI) both in their raw and dosage forms. In the first method, the two cited drugs were determined simultaneously using first derivative (D 1 ) method. It was accomplished by measuring peak heights at 275 nm and 344 nm, for SFV and LDI, respectively, in concentration ranges of 5 -80 μg/mL and 3 -50 μg/mL, for SFV and LDI, respectively. In the second one, a first derivative of ratio spectra ( 1 DD) method was adopted to quantify SFV in concentration range of 5 -80 µg/mL. It was adopted by measuring the peak amplitudes (valley and peak) at 259 nm and 280 nm, using 25 µg/mL LDI as a divisor. The proposed method was also used to determine LDI in concentration range of 3 -50 µg/mL by recording the peak amplitudes (valley and peak) at 319 nm and 375 nm, using 80 µg/mL SFV as a divisor. The developed methods were validated with respect to linearity, accuracy, precision, selectivity, robustness and limits of detection and quantification (LOD and LOQ), as per the guidelines of International Conference on Harmonization (ICH)-Q2B.

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Section: Resultsmentioning

confidence: 99%

Validated simultaneous spectrophotometric quantification of a new antiviral combination

Abdel-Gawad

2017

Eur. J. Chem.

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“…First derivative ratio spectra (DD 1 ): Mixtures of compounds with highly overlapped spectra have been resolved by the use of the ratio spectra with high accuracy [9][10][11]. The absorption spectra of RIV with different concentration were recorded in the range of 200-400 nm and stored in IBMPC.…”

Section: First Derivative (D 1 )mentioning

confidence: 99%

High Performance Liquid Chromatography, TLC Densitometry, Firstderivative and First-derivative ratio spectrophotometry for de-termination of Rivaroxaban and its alkaline Degradates in Bulk Powder and its Tablets

Ib¹,

Aa²,

Ma³

2013

J Chromat Separation Techniq

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Four sensitive and selective stability indicating methods for the determination of rivaroxaban (RIV) were developed. Method a was an isocratic RP-HPLC, good resolution between peaks corresponding to the degradates from analyte was achieved on C18 column. The mobile phase is 1.2% w/v potassium dihydrogen phosphate pH 3.5 ± 0.2 and acetonitrile (70:30, v/v). The detection was carried out at 280 nm. Method B depends on quantitative densitometric determination of thin layer chromatography TLC of rivaroxaban in the presence of it's degradates without any interference. The developing system was chloroform-isobutyl alcohol (50:50 v/v).The chromatogram was scanned at 280 nm. Method C was based on the first derivative (D 1 ) measurement of the drug at 237.4 nm; zero contribution point of its alkaline degradates. Method D was based on the resolution of the drug and its alkaline degradates by first derivative ratio spectra (DD 1 successfully applied for the determination of rivaroxaban in bulk powder, pharmaceutical formulation and in presence of its alkaline degradates. The obtained results were statistically analyzed and compared with those obtained by the reported method.

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“…When the standard spectrum of two of compounds in the same ternary mixture are used as a double divisor, we obtain (5) The next step is to divide the equation (4) (6) The equation (6) is simplified as (7) where represents a constant for a given linear concentration range with respect to i in a certain region or point of wavelength. When Cº X and Cº Y are the same or very close to each other, namely Cº X = Cº Y or Cº X Cº Y , we can write (8) and the equation (7) becomes (9) The equation (9) corresponds to the double divisorratio spectra of Z compound in a given ternary mixture.…”

Section: Double Divisor-ratio Spectra Proceduresmentioning

confidence: 99%

“…Several spectrophotometric methods, such as derivative spectrophotometry, [1][2][3][4][5] ratio spectra derivative method, 6 ratio spectra derivative-zero crossing method, 7-9 DDRS-DS method [10][11][12][13][14] and double divisor-ratio spectra derivative-zero crossing method 15 have been reported in the literature and applied for ternary and quaternary mixtures. However, it was observed that the derivative spectrophotometry and ratio spectra derivative method provide a good analytical resolution of binary mixtures but these two methods do not give always desirable results for the analysis of ternary and quaternary mixtures.…”

Section: Introductionmentioning

confidence: 99%

Application of Haar and Mexican hat wavelets to double divisor-ratio spectra for the multicomponent determination of ascorbic acid, acetylsalicylic acid and paracetamol in effervescent tablets

Dinç¹,

Băleanu²

2008

J. Braz. Chem. Soc.

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A determinação simultânea de ácido ascórbico (AA), ácido acetilsalicílico (ASP) e paracetamol (PAR) em misturas sintéticas e tabletes efervescentes foi realizada usando-se as técnicas de transformações de Haar e transformações de onda pequena tipo chapéu mexicano (HAAR-CWT e MEXH-CWT, respectivamente), juntamente com a técnica de divisor duplo. Os métodos de processamento de sinal são baseados na aplicação de HAAR-CWT e MEXH-CWT aos espectros relativos com divisor duplo (DDRS). Estes espectros foram obtidos pela divisão do espectro de absorção do composto puro e suas misturas ternárias, por um divisor duplo ou espectro padrão correspondente à mistura de dois compostos em mistura ternária. O uso combinado de HAAR-CWT e MEXH-CWT com espectros relativos com divisor duplo (DDRS) foi denominado DDRS-HAAR CWT e DDRS-MEXH CWT. Para avaliar a habilidade ou aplicabilidade dos métodos desenvolvidos DDRS-CWT, foi aplicado como comparação, o método espectrofotométrico por derivada de espectros relativos com divisor duplo (DDRS-DS), às amostras mencionadas acima, contendo AA, ASP e PAR. Resultados satisfatórios foram obtidos.Simultaneous determination of ascorbic acid (AA), acetylsalicylic acid (ASP) and paracetamol (PAR) in their synthetic mixtures and effervescent tablets were performed by Haar and Mexican continuous wavelet transforms (HAAR-CWT and MEXH-CWT, respectively) together with double divisor technique. The signal processing methods are based on the application of HAAR-CWT and MEXH-CWT to the double divisor-ratio spectra (DDRS). These spectra were obtained by dividing the absorption spectra of pure compound and its ternary mixtures by a double-divisor or standard spectrum corresponding to a mixture of two compounds in ternary mixture. A combined use of HAAR-CWT and MEXH-CWT with double divisor-ratio spectra (DDRS) was denoted by DDRS-HAAR CWT and DDRS-MEXH CWT. To check the ability or applicability of the developed DDRS-CWT methods, the double divisor-ratio spectra-derivative spectrophotometric (DDRS-DS) method, as a comparison method, was applied to the above mentioned samples containing AA, ASP and PAR and satisfactory results were obtained.

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A new spectrophotometric method for quantitative multicomponent analysis resolution of mixtures of salicylic and salicyluric acids

Cited by 328 publications

References 8 publications

Validated simultaneous spectrophotometric quantification of a new antiviral combination

Validated simultaneous spectrophotometric quantification of a new antiviral combination

High Performance Liquid Chromatography, TLC Densitometry, Firstderivative and First-derivative ratio spectrophotometry for de-termination of Rivaroxaban and its alkaline Degradates in Bulk Powder and its Tablets

Application of Haar and Mexican hat wavelets to double divisor-ratio spectra for the multicomponent determination of ascorbic acid, acetylsalicylic acid and paracetamol in effervescent tablets

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