A new skeleton flavonoid and a new lignan from Portulaca oleracea L. and their activities

Duan, Yang; Zhang, Ying; He, Fan; Ying, Xixiang; Lu, Jia; Yang, Guanlin

doi:10.1016/j.fitote.2021.104993

Cited by 27 publications

(12 citation statements)

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“…A phytochemical survey of the natural products found in P. oleracea extracts was reported in 2015 (Zhou et al 2015) and 2017 (Iranshahy et al 2017) but over the past 3-4 years, many other new natural products have been identified from the plants. We can cite the alkaloid oleraisoindole aforementioned (Jiang et al 2018) and its hydroxylated analogue named oleroisoindole A (Ma et al 2021), the alkaloid portulacatones A and B and portulacatal (Gu et al 2020;Cui et al 2021), the alkaloid 1-carbomethoxy-β-carboline (Kim et al 2019), a series of water-soluble alkaloids called oleraceins (Fu et al 2021), but also several homoisoflavonoids (Lee et al 2019), the chalcone 2,4'-dihydroxy-3',5'-dimethoxychalcone (Wang et al 2020) and chromanone derivatives such as 5,7dimethoxy-3-(2'hydro-xybenzyl)-4-chromanone and HMchromanone (Park et al 2019;Je et al 2021;Kang et al 2021;Park et al 2021), a few lignans such as oleralignans A and B (Wei et al 2019;Duan et al 2021) and other compounds (Miao et al 2019;Wei et al 2019;Xiu et al 2019;Zhao et al 2019b;Wang et al 2020). Recently, a metabolomic analysis of several taxa of P. oleracea L. has identified 85 metabolites including the large series of cyclo-dopa alkaloids, designated oleraceins A-to-W (Farag and Shakour 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Otherwise, there is little information about this compound, apart from its modest antioxidant capacity (IC50: 40.1 M in the standard DPPH (1,1-diphenyl-2-picryl-hydrazyl) assay and weak antiproliferative activities against various cancer cell lines in vitro (IC50: 42-82 M). OL-G exhibits a modest antiinflammatory activity in vitro (Duan et al 2021). Oleracone H (OL-H) is only described in a Chinese patent (Table 2).…”

Section: Figure 3 Structures Of Oleracone Natural Productsmentioning

confidence: 99%

“…The biologically active compounds found in P. oleracea are extremely diversified, comprising flavonoids, cyanins, lignans, terpenes, phenolic alkaloids as well as bioactive polysaccharides (Yang et al 2009;Zhou et al 2015;Duan et al 2021). The plant is known for decades but novel natural products are regularly isolated and characterized (Nemzer et al 2021;Park et al 2021), such as oleralignan A (Xu et al 2021) andoleraceins X andY (Fernández-Poyatos et al 2021).…”

Section: Introductionmentioning

confidence: 99%

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Review: Natural products isolated from Portulaca oleracea (purslane, Ma-Chi-Xian): Focus on oleraciamides and oleracones

Bailly

2021

Nusantara Biosci

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Abstract. Bailly C. 2021. Review: Natural products isolated from Portulaca oleracea (purslane, Ma-Chi-Xian): Focus on oleraciamides and oleracones. Nusantara Bioscience 13: 202-210. The plant Portulaca oleracea L., known as purslane in English and Ma-Chi-Xian in Chinese, is largely used in traditional medicine to treat a variety of diseases and conditions, including dysentery, urinary tract dysfunctions, and post-partum bleeding. It is also an edible plant, with a high nutritional potential. Extracts of P. oleracea display antioxidant, anti-inflammatory and antiproliferative activities, associated with the presence of numerous bioactive secondary metabolites, including alkaloids, terpenoids, lignans and polysaccharides. The present review provides a specific focus on two sub-groups of natural products isolated in recent years from P. oleracea: the alkaloids oleraciamides A-to-G, and the oleracones A-to-L which are mostly flavonoids. Their structural diversity and pharmacological properties, described in recent publications and patents, have been analyzed. These two subgroups of natural products deserve additional studies to delineate their mechanism of action. They could serve as a starting point to the design of novel anti-inflammatory agents, at least for some of them. This review provides a global view of these compounds, necessary to promote further phytochemical studies and to better apprehend the traditional use of the plant and its extracts.

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Section: Discussionmentioning

confidence: 99%

Section: Figure 3 Structures Of Oleracone Natural Productsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Review: Natural products isolated from Portulaca oleracea (purslane, Ma-Chi-Xian): Focus on oleraciamides and oleracones

Bailly

2021

Nusantara Biosci

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“…Flavonoid compounds are associated with a number of biological activities, their antioxidant, anticancer, anti-inflammatory, antidiabetic, antimicrobial, antidyslipidemic, neuroprotective, antiosteoporotic, cytoprotective, hepatoprotective, vasoprotective properties being much studied [ 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 ]. Flavonoids are known to decrease cardiovascular risk and cancer-associated mortality [ 76 ].…”

Section: Flavonoidsmentioning

confidence: 99%

Two Important Anticancer Mechanisms of Natural and Synthetic Chalcones

Constantinescu

Mihis

2022

IJMS

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ATP-binding cassette subfamily G and tubulin pharmacological mechanisms decrease the effectiveness of anticancer drugs by modulating drug absorption and by creating tubulin assembly through polymerization. A series of natural and synthetic chalcones have been reported to have very good anticancer activity, with a half-maximal inhibitory concentration lower than 1 µM. By modulation, it is observed in case of the first mechanism that methoxy substituents on the aromatic cycle of acetophenone residue and substitution of phenyl nucleus by a heterocycle and by methoxy or hydroxyl groups have a positive impact. To inhibit tubulin, compounds bind to colchicine binding site. Presence of methoxy groups, amino groups or heterocyclic substituents increase activity.

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“…1. When it is consumed, there has slightly sour and salty taste resembling the taste of spinach [9] as a result of the crassulacean acid metabolism (CAM) process, namely the process of assimilation of carboxylic acids from CO2 utilization [10].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Characteristics of Various Dimsum Fortified with Purslane Leaves

Mushollaeni

Tantalu

Ghofur

2022

EJFOOD

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(One of the villages with abundant natural resources is Wonosalam Village in Jombang, East Java. One of the potentials is purslane (Portulaca oleracea) but underutilized yet and just known as a wild plant or weed. The availability of pursiane plants reaches 5-8 quintals/month from each population plot. However, this plant will be discarded because it interferes with the growth of economically valuable plants. Whereas according to research, purslane plants contain lots of phenolic bioactive compounds, flavonoids, carotenoids, and essential fatty acids that are useful as antioxidants and disease prevention. Therefore, this experiment aimed to obtain the best composition of various processed dimsum fortified using purslane leaves. This study used a randomized block design with various formulations of dimsum fortified using purslane leaves, namely purslane dumpling (SK), fantasy purslane dumpling (SKF), purslane drew-dumpling (DK) and purslane manti (KM) the results showed that pursiane dumplings were the best treatment, with physico-chemical parameters of protein, fat, water, ash, and carbohydrate content of 14.10%; 5.4%; 50.54%; 2.37%; and 21.8%. All kinds of dimsum fortified with purslane leaves contain unsaturated fatty acids from the medium-chain fatty acid (MCFAs) and polyunsaturated fatty acids (PUFAs) group.

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A new skeleton flavonoid and a new lignan from Portulaca oleracea L. and their activities

Cited by 27 publications

References 40 publications

Review: Natural products isolated from Portulaca oleracea (purslane, Ma-Chi-Xian): Focus on oleraciamides and oleracones

Review: Natural products isolated from Portulaca oleracea (purslane, Ma-Chi-Xian): Focus on oleraciamides and oleracones

Two Important Anticancer Mechanisms of Natural and Synthetic Chalcones

Phytochemical Characteristics of Various Dimsum Fortified with Purslane Leaves

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