A New “Silver-Bullet” to treat caries in children – Nano Silver Fluoride: A randomised clinical trial

Santos, Valdeci Elias dos; Filho, Arnoldo Vasconcelos de Alencar; Targino, Andréa Gadelha Ribeiro; Flores, Miguel Angel Pelágio; Galembeck, André; Júnior, Arnaldo de França Caldas; Rosenblatt, Aronita

doi:10.1016/j.jdent.2014.05.017

Cited by 172 publications

(233 citation statements)

References 16 publications

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“…Based on the fluorapatite crystals shown in the SNF group, it can be stated that SNF has the same effect in inhibiting demineralization and increasing the hardness of the demineralized dentin. Based on the study of Santos et al (in vivo) related to treating caries in children, it was concluded that NSF is more effective in increasing hardness and inhibiting caries in dentin than in no application in dentin [12]. The SEM results after PPF treatment showed a deposition layer of amorphous products along the surface of the dentin with a closed tubule at concentrations of 3% and 10%.…”

Section: Discussionmentioning

confidence: 99%

“…Fluoride is available in a variety of dosage forms including sodium diamine fluoride (SDF), nanosilver fluoride (NSF), and propolis fluoride (PPF) [4][5][6][7][8][9][10][11][12][13][14]. Previous studies using SDF have shown that SDF consists of silver (Ag) and fluoride (F); silver acts as an antimicrobial agent and fluoride plays a role in enhancing remineralization as a strong anticaries agent [11].…”

Section: Introductionmentioning

confidence: 99%

“…SDF causes black stains on the teeth, so NSF is formulated as an alternative agent alongside SDF in dealing with dental caries. NSF has components similar to SDF, including silver (in the form of nanoparticles) and fluoride [12].…”

Section: Introductionmentioning

confidence: 99%

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The Potential of Several Fluoride-Based Varnishes as Remineralization Agents: Morphological Studies, Dentin Surface Hardness, and Crystallinity Tests

et al. 2018

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Objectives:This study was conducted to analyze the effects of several fluoride-based varnishes: Sodium diamine fluoride (SDF), nanosilver fluoride (NSF), and propolis fluoride (PPF). Fluoride-based varnish is proven to remineralize and arrest caries progression with minimal side effects. SDF, the gold standard for this study, compared to NSF and PPF to observe the dentin morphology, hardness, and crystallinity test.Methods: Dentin blocks were allocated and divided into control groups and treatment groups with SDF (38%), NSF (3.16%, 3.66%, and 4.16%), and PPF (3%, 6%, and 10%). The dentin discs were demineralized using a demineralization solution (pH 4.4) for 96 h. Each dentin disc in the treatment group received a topical application of various fluoride-based varnishes and was then subjected to pH cycling for 8 days. The surface morphology of dentin was observed by a scanning electron micrograph (SEM), dentin hardness was analyzed by a Vickers microhardness tester, and the crystal characteristics of dentin blocks were investigated by X-ray diffraction (XRD). Results:This study showed crystal fluorapatite on the dentin surface of SDF and NSF. There was an amorphous layer on the dentin surface of PPF (10%) detected when using SEM. The Vickers hardness number of dentin increased after the application of SDF, NSF, and PPF. XRD revealed precipitates of apatite compounds, calcium compounds, and metal compounds in the treatment groups in higher concentrations than in the control (demineralized) group. Conclusion:It was concluded that SDF, NSF, and PPF were effective for dentin remineralization. Hence, NSF and PPF fluoride-based varnishes are promising as anticariogenic agents.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Potential of Several Fluoride-Based Varnishes as Remineralization Agents: Morphological Studies, Dentin Surface Hardness, and Crystallinity Tests

et al. 2018

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“…Fluoride ions in PPF act as a remineralization agent because of their ability to increase tooth endurance to acid by forming fluorapatite. PPF was expected to have fewer side effects of SDF and NSF [11][12][13][14].…”

Section: Soekanto Et Almentioning

confidence: 99%

Comparison of the Potency of Several Fluoride-Based Varnishes as an Anticariogenic on Calcium, Phosphate, and Fluoride Ion Levels

et al. 2018

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Objectives: The purpose of this present study was to analyze several fluoride-based varnishes: Silver diamine fluoride (SDF), nanosilver fluoride (NSF), and propolis fluoride (PPF). Fluoride-based varnish is proven to act as antibacterial and remineralization agents that arrested caries progression with minimal side effects. SDF, the golden standard for this study, was compared to NSF and PPF, which were made in our own laboratory, to evaluate their ability to release calcium, phosphate, and fluoride ions and act as anticariogenic agents.Methods: Human dentin discs were prepared and divided into control groups and treatment groups with SDF (38%), NSF (3.16%, 3.66%, and 4.16%), and PPF (3%, 6%, and 10%). The dentin discs were demineralized using a demineralization solution (pH 4.4) for 96 h. Each dentin disc in the treatment group received a topical application of various fluoride-based varnishes and then was subjected to pH-cycling for 8 days. The quantity of calcium, phosphate, and fluoride ions on the dentin discs surface was compared after being detected using energy dispersive X-ray spectroscopy. Results:The result revealed that the calcium ion levels in groups NSF and PPF increased significantly compared to SDF. The levels of phosphate ions and fluoride ions in groups NSF and PPF increased significantly compared to SDF. Conclusion:The study concluded that, in contrast to SDF, the prepared NSF and PPF fluoride-based varnishes were shown to release calcium, phosphate, and fluoride ions in this study. Hence, NSF and PPF fluoride-based varnishes are promising as anticariogenic agents.

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“…The efficiency of this approach was explored in a recent clinical study by using formulations with silver nanoparticles. [40] …”

mentioning

confidence: 99%

Strategies for Biofilm Inhibition.

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Reddy³

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A New “Silver-Bullet” to treat caries in children – Nano Silver Fluoride: A randomised clinical trial

Abstract: NSF was demonstrated to be effective in arresting caries in children in poor communities.

Cited by 172 publications

References 16 publications

The Potential of Several Fluoride-Based Varnishes as Remineralization Agents: Morphological Studies, Dentin Surface Hardness, and Crystallinity Tests

The Potential of Several Fluoride-Based Varnishes as Remineralization Agents: Morphological Studies, Dentin Surface Hardness, and Crystallinity Tests

Comparison of the Potency of Several Fluoride-Based Varnishes as an Anticariogenic on Calcium, Phosphate, and Fluoride Ion Levels

Strategies for Biofilm Inhibition.

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