“…SDF has been used as a gold standard in several investigations [ 23 – 25 , 52 – 59 ] in different concentrations in deciduous teeth with a high risk of active caries [ 20 , 59 , 60 ], effectively preventing and controlling them [ 23 , 24 , 57 , 61 – 63 ]. However, it has shown adverse effects, such as causing ulcerations and staining in oral mucosa [ 64 ] that are painful due to accidental contact with the solution [ 20 , 65 ], which may disappear within 48 hours [ 21 , 65 ] and the black staining of carious tissue [ 65 – 67 ] due to the oxidation process of the ionic silver contained in its formulation [ 4 , 68 ]; however, as previously demonstrated, the use of a cariostatic agent with silver nanoparticles does not cause darkening in demineralized teeth [ 46 – 48 , 51 ]. Besides, practically all studies have demonstrated the anticariogenic and remineralizing effect of silver nanoparticles alone [ 45 ] and in combination with various components, being superior to conventional treatments [ 48 – 51 ] such as silver diamine fluoride when applied once a year, with the advantage of not staining black dental tissue, the reason being they do not form oxides when in contact with oxygen in the environment, no metallic taste, and lower cost compared to SDF [ 4 , 51 ].…”