A New Retinoid-Like Compound That Activates Peroxisome Proliferator-Activated Receptors and Lowers Blood Glucose in Diabetic Mice

Deng, Tuo; Song, Shan; Li, Zhi Bin; Wu, Zhong Wen; Liao, Chen; Ko, Ben C.B.; Lu, Xiaoping; Cheng, Jing; Ning, Zhi Qiang

doi:10.1248/bpb.28.1192

Cited by 43 publications

(9 citation statements)

References 16 publications

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“…PPAR- γ is a critical target of a number of insulin-sensitizing drugs [3–5]. Treatment with EBN significantly increased the transcriptional activity of PPAR- γ in HEK293 cells (Figure 2(a)).…”

Section: Resultsmentioning

confidence: 99%

“…PPAR- γ participates in glucose uptake, and PPAR- γ agonists increase the sensitivity of insulin receptors [3–5]. In addition to thiazolidinedione, a PPAR- γ agonist that is used clinically, naturally occurring ingredients or compounds have also been used as PPAR- γ agonists to significantly improve insulin resistance [3, 18, 19].…”

Section: Discussionmentioning

confidence: 99%

“…It is believed that natural ingredients are safer than synthetic compounds because they have been used for a long time [1, 2]. The results of a number of studies conducted by other researchers and our previous study also suggested that naturally occurring compounds could exert beneficial health effects in the treatment of diabetes by modulating cellular signaling pathways [2–5]. Among signaling molecules, peroxisome proliferator-activated receptor gamma (PPAR- γ ) regulates fatty acid and glucose metabolism.…”

Section: Introductionmentioning

confidence: 97%

“…Among signaling molecules, peroxisome proliferator-activated receptor gamma (PPAR- γ ) regulates fatty acid and glucose metabolism. PPAR- γ has been implicated in the pathology of obesity and diabetes [3–5]. PPAR- γ agonists such as glitazone have been used to treat hyperglycemia [6].…”

Section: Introductionmentioning

confidence: 99%

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Boehmeria niveaStimulates Glucose Uptake by Activating Peroxisome Proliferator-Activated Receptor Gamma in C2C12 Cells and Improves Glucose Intolerance in Mice Fed a High-Fat Diet

Kim

Sung²,

Park³

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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We examined the antidiabetic property of Boehmeria nivea (L.) Gaud. Ethanolic extract of Boehmeria nivea (L.) Gaud. (EBN) increased the uptake of 2-[N-(nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose in C2C12 myotubes. To examine the mechanisms underlying EBN-mediated increase in glucose uptake, we examined the transcriptional activity and expression of peroxisome proliferator-activated receptor gamma (PPAR-γ), a pivotal target for glucose metabolism in C2C12 myotubes. We found that the EBN increased both the transcriptional activity and mRNA expression levels of PPAR-γ. In addition, we measured phosphorylation and expression levels of other targets of glucose metabolism, such as AMP-activated protein kinase (AMPK) and protein kinase B (Akt/PKB). We found that EBN did not alter the phosphorylation or expression levels of these proteins in a time- or dose-dependent manner, which suggested that EBN stimulates glucose uptake through a PPAR-γ-dependent mechanism. Further, we investigated the antidiabetic property of EBN using mice fed a high-fat diet (HFD). Administration of 0.5% EBN reduced the HFD-induced increase in body weight, total cholesterol level, and fatty liver and improved the impaired fasting glucose level, blood insulin content, and glucose intolerance. These results suggest that EBN had an antidiabetic effect in cell culture and animal systems and may be useful for preventing diabetes.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Boehmeria niveaStimulates Glucose Uptake by Activating Peroxisome Proliferator-Activated Receptor Gamma in C2C12 Cells and Improves Glucose Intolerance in Mice Fed a High-Fat Diet

Kim

Sung²,

Park³

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…The expression of PPARγ and RXRα which have been recognized as crucial players in the pathogenesis of atherosclerosis was associated with a more pronounced disease progression in patients with advanced carotid atherosclerotic lesions [72]. More targeted modulation of function through ligands design has been proposed as a strategy to possibly overcome observed rexinoids side effects that have limited the use of these compounds in the treatment of metabolic diseases [21,73]. It is exciting options that the therapy of metabolic diseases originating from the synthesis of heterodimer-selective rexinoids for PPARγ/RXRα combining with PPARγ agonists.…”

Section: Modulation Of Permissive Ppar/rxr Heterodimersmentioning

confidence: 99%

The Function of Retinoid X Receptor α in Cancer Cells

Huang¹,

Chen²,

Shen³

2016

Biol syst Open Access

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The retinoid X receptor (RXR) is a member of the steroid/thyroid hormone superfamily of nuclear receptors (NRs) which are transcription factors that are essential in embryonic development, maintenance of differentiated phenotypes, metabolism and cell death. This review is to provide an overview of the mechanism of RXRα and RXRα signaling pathways involving RXR/TR3, RAR/RXR, PPAR/RXR, VDR/RXR, LXR/RXR, FXR/RXR in cancer cells and other diseases, which will enhance our ability to design rational therapeutic drugs for cancer. Recent studies have shown that an N-terminally truncated RXRα (tRXRα) exists in several cancer cell lines and primary tumors, which is considered as a kind of oncoprotein, demonstrating the new suitability of targeting tRXRα for cancer therapy.

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Activation of Allylic CF bonds: Palladium‐Catalyzed Allylic Amination of 3,3‐Difluoropropenes

et al. 2010

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A New Retinoid-Like Compound That Activates Peroxisome Proliferator-Activated Receptors and Lowers Blood Glucose in Diabetic Mice

Cited by 43 publications

References 16 publications

Boehmeria niveaStimulates Glucose Uptake by Activating Peroxisome Proliferator-Activated Receptor Gamma in C2C12 Cells and Improves Glucose Intolerance in Mice Fed a High-Fat Diet

Boehmeria niveaStimulates Glucose Uptake by Activating Peroxisome Proliferator-Activated Receptor Gamma in C2C12 Cells and Improves Glucose Intolerance in Mice Fed a High-Fat Diet

The Function of Retinoid X Receptor α in Cancer Cells

Activation of Allylic CF bonds: Palladium‐Catalyzed Allylic Amination of 3,3‐Difluoropropenes

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