A New Parameter Predicting Chronic Total Occlusion of Coronary Arteries

Vatankulu, Mehmet Akıf; Sönmez, Osman; Ertaş, Gökhan; Bacaksız, Ahmet; Turfan, Murat; Erdoğan, Ercan; Taşal, Abdurrahman; Kul, Şeref; Uyarel, Hüseyin; Göktekín, Ömer

doi:10.1177/0003319713486339

Cited by 31 publications

(35 citation statements)

References 21 publications

(36 reference statements)

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“…We also observed that PDW, an indicator of prothrombotic status, was significantly higher in B blood group subjects than in A and O blood group subjects ( P = 0.019 and P = 0.006, respectively). In accordance with our study, many investigations have shown that PDW was significantly higher in subjects with CAD and thrombolysis failure . However, other studies have reported that there is no relationship between PDW and the extent of CAD …”

Section: Discussionsupporting

confidence: 92%

The relationship between platelet indices and ABO blood groups in healthy adults

Çelik

Düzenli

Aslan

et al. 2018

Clinical Laboratory Analysis

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Background ABO blood groups have been suggested to have a high correlation with cardiovascular diseases (CVDs). It has also been postulated that platelet indices, including mean platelet volume (MPV) and platelet distribution width (PDW), are very important in the development and progression of CVDs. However, despite these common associations with CVDs, as far as we know, there are no studies investigating platelet indices in ABO blood groups. Thus, the aim of this study was to investigate whether platelet indices are associated with ABO blood groups. Methods The study included 301 healthy volunteers (99 women and 202 men; mean age: 32.59 ± 7.52 years) whose blood groups were determined by the gel column method using agglutination techniques. Platelet indices were studied by an automated blood counter. Results No considerable differences in age, gender, or Rh factors were observed among ABO blood groups. MPV was detected to be considerably lower in O and A blood group subjects than in AB and B blood group subjects. Similarly, PDW was significantly lower in O and A blood group subjects than in B blood group subjects. Additionally, MPV in the O blood group subjects was significantly lower than in the non‐O blood group subjects. Conclusions Because MPV and PDW are used as markers of CVDs, individuals with O and A blood groups in this study may be considered to have a lower risk of CVDs than AB and B blood group subjects. However, prospective cohort studies involving a greater number of volunteers are needed to elucidate these relationships.

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Section: Discussionsupporting

confidence: 92%

The relationship between platelet indices and ABO blood groups in healthy adults

Çelik

Düzenli

Aslan

et al. 2018

Clinical Laboratory Analysis

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“…Our results show that in patients presenting with STEMI, PDW can predict the presence of CTO. The association between CTO and PDW has also been showed by Vatankulu et al [15] in patients with stable CAD who underwent coronary artery angiography. De Luca et al [16] found no association between PDW and the extent of CAD, but patients with three vessels affected had a tendency towards higher PDW values.…”

Section: Platelet Indices and Ctosupporting

confidence: 59%

Platelet indices and platelet-to-lymphocyte ratio predict coronary chronic total occlusion in patients with acute ST-elevation myocardial infarction

Hadadi

Șuș

Lakatos

et al. 2015

Revista Romana De Medicina De Laborator

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Coronary chronic total occlusion (CTO) is caused by organized thrombi or atherosclerotic plaque progression. The presence of a CTO is an independent predictor of mortality in patients presenting with ST-segment elevation myocardial infarction (STEMI). Platelets have a crucial role in the pathophysiology of atherosclerosis. The aim of this retrospective study was to investigate platelet indices as predictors of CTO in patients with STEMI treated with primary percutaneous coronary intervention (pPCI). A total number of 334 patients admitted for STEMI between January 2011 and December 2013 were included and divided in two groups based on the presence of CTO (48 patients in CTO+ group, 286 patients in CTO-group). Platelet count, mean platelet volume (MPV), platelet distribution width (PDW), platelet-large cell ratio (P-LCR), lymphocyte and neutrophil count determined on admission were analyzed. MPV was larger in patients with CTO compared with patients without CTO (p=0.02), as were PDW (p=0.03) and P-LCR (p=0.01). Platelet-to-lymphocyte ratio (PLT/LYM) was lower in patients with

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“…These morphological changes promote platelet adhesion and aggregation, which in turn may trigger blood flow abnormalities and future vascular Platelets and contrast-induced nephropathy Sahin et al 247 complications [22]. Association between platelet activation, endothelial dysfunction and ischemic coronary heart disease has been established [12][13][14][15]. Association between platelet activation, endothelial dysfunction and ischemic coronary heart disease has been established [12][13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Contribution of platelets indices in the development of contrast-induced nephropathy

Şahin

Karabulut

Avcı

et al. 2015

Blood Coagulation &Amp; Fibrinolysis

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Contrast-induced nephropathy (CIN) accounts for 10% of hospital-acquired renal failure, causes a prolonged in-hospital stay and represents a powerful predictor of poor clinical outcome. The underlying mechanism of the CIN development remains unclear and seems to be multifactorial. The potential link between platelet indices such as mean platelet volume (MPV) and platelet distribution width (PDW) with CIN is unknown. Herein, we aimed to investigate the correlation between MPV and PDW levels with the development of CIN. The incidence of CIN (20.5%) was prospectively evaluated in 430 patients with diagnosis of acute coronary syndrome. Initial creatinine (1.13 ± 0.25 vs. 1.05 ± 0.27 mg/dl, P = 0.01) and PDW (40.1 ± 20.2 vs. 34.5 ± 19.9%, P = 0.02) levels and the total volume of contrast media used (121 ± 61 vs. 94 ± 42 ml, P = 0.01) were higher in patients who developed CIN. MPV was similar between the two groups (P = 0.80). In a univariate regression analysis, age, increased creatinine, uric acid, phosphate, PDW levels and higher total volume of contrast media used were significantly correlated with CIN incidence. However, in a multivariate analysis, only total volume of CM used [odds ratio (OR) 1.011, 95% confidence interval (CI) 1.006-1.016; P = 0.01], increased age (OR 1.026, 95% CI 1.00-1.052; P = 0.05) and increased PDW levels (OR 1.009, 95% CI 1.00-1.022; P = 0.04) remained as the independent predictors of CIN. Among platelet indices, PDW, but not MPV, was associated with CIN development. The clinical significance of such link remains unclear, but may indicate involvement of platelet activation in CIN pathogenesis.

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A New Parameter Predicting Chronic Total Occlusion of Coronary Arteries

Cited by 31 publications

References 21 publications

The relationship between platelet indices and ABO blood groups in healthy adults

The relationship between platelet indices and ABO blood groups in healthy adults

Platelet indices and platelet-to-lymphocyte ratio predict coronary chronic total occlusion in patients with acute ST-elevation myocardial infarction

Contribution of platelets indices in the development of contrast-induced nephropathy

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