A New Natural Biomaterial: Sheep Dentine Derived Hydroxyapatite

Akyurt, Nuran; Yetmez, Mehmet; Karacayli, U.; Gündüz, Oğuzhan; Agathopoulos, Simeon; Gökçe, Hasan; Öveçoğlu, M. Lütfi; Oktar, Faik N.

doi:10.4028/www.scientific.net/kem.493-494.281

Cited by 9 publications

(7 citation statements)

References 21 publications

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“…For example, the use of egg-shell or sea-shell wastes, which represent the most abundant by-products of the food industry, has been found as a very promising sustainable resource to produce HA at a low cost with little impact to the environment [88,119,120,121]. Apart from the method of synthesis, the quality of non-synthetic HA (e.g., purity, grain size, properties) is strongly dependent on the biological source, location, age and fabrication process [1,55,92,93,94,99,100,104,109,111,112,116].…”

Section: Preparation Methods and Synthesis Routes Of Hydroxyapatitmentioning

confidence: 99%

Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

et al. 2018

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High-performance bioceramics are required for preventing failure and prolonging the life-time of bone grafting scaffolds and osseous implants. The proper identification and development of materials with extended functionalities addressing socio-economic needs and health problems constitute important and critical steps at the heart of clinical research. Recent findings in the realm of ion-substituted hydroxyapatite (HA) could pave the road towards significant developments in biomedicine, with an emphasis on a new generation of orthopaedic and dentistry applications, since such bioceramics are able to mimic the structural, compositional and mechanical properties of the bone mineral phase. In fact, the fascinating ability of the HA crystalline lattice to allow for the substitution of calcium ions with a plethora of cationic species has been widely explored in the recent period, with consequent modifications of its physical and chemical features, as well as its functional mechanical and in vitro and in vivo biological performance. A comprehensive inventory of the progresses achieved so far is both opportune and of paramount importance, in order to not only gather and summarize information, but to also allow fellow researchers to compare with ease and filter the best solutions for the cation substitution of HA-based materials and enable the development of multi-functional biomedical designs. The review surveys preparation and synthesis methods, pinpoints all the explored cation dopants, and discloses the full application range of substituted HA. Special attention is dedicated to the antimicrobial efficiency spectrum and cytotoxic trade-off concentration values for various cell lines, highlighting new prophylactic routes for the prevention of implant failure. Importantly, the current in vitro biological tests (widely employed to unveil the biological performance of HA-based materials), and their ability to mimic the in vivo biological interactions, are also critically assessed. Future perspectives are discussed, and a series of recommendations are underlined.

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Section: Preparation Methods and Synthesis Routes Of Hydroxyapatitmentioning

confidence: 99%

Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

et al. 2018

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“…In order to make samples suited for compression and microhardness testing, the powder was crushed between hardened steel dies. Sintered powder compacts were obtained at various temperatures: 1000, 1100, 1200, and 1300°C in air [ 42 ]. The findings of this study revealed that the HA material derived from sheep tooth dentine may be considered a promising source of HA for bioactive ceramics production.…”

Section: Biomaterials From Sheep-derived Wastementioning

confidence: 99%

Advances in biomaterial production from animal derived waste

et al. 2021

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Animal derived waste, if not disposed properly, could pose a threat to the environment and its inhabitants. Recent advancements in biotechnological and biomedical interventions have enabled us to bioengineer these valuable waste substrates into biomaterials with diversified applications. Rearing and processing of poultry, cattle, sheep, goat, pig, and slaughterhouse waste can aid in effective waste valorization for the fabrication of biopolymers, composites, heart valves, collagen, scaffolds, pigments and lipids, among other industrially important biomaterials. Feathers and eggshell waste from the poultry industry can be used for producing keratinous proteins and biocomposites, respectively. Cattle dung, hoofs and cattle hide can be used for producing hydroxyapatite for developing scaffolds and drug delivery systems. Porcine derived collagen can be used for developing skin grafts, while porcine urinary bladder has antiangiogenic, neurotrophic, tumor-suppressive and wound healing properties. Sheep teeth can be used for the production of low-cost hydroxyapatite while goat tissue is still underutilized and requires more in-depth investigation. However, hydrolyzed tannery fleshings show promising potential for antioxidant rich animal feed production. In this review, the recent developments in the production and application of biomaterials from animal waste have been critically analyzed. Standardized protocols for biomaterial synthesis on a pilot scale, and government policy framework for establishing an animal waste supply chain for end users seem to be lacking and require urgent attention. Moreover, circular bioeconomy concepts for animal derived biomaterial production need to be developed for creating a sustainable system.

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“…Akyurt et al [63] produced HA from sheep teeth, by calcination and sintering at different temperatures (1000-1300 • C). Compression strength and microhardness measurements were performed and the obtained results were the best in the case of samples sintered at 1300 • C. This behavior was attributed to the F-content presence in the enamel structure.…”

Section: Extraction Of Ha From Mammalian Bonesmentioning

confidence: 99%

Current Status on Pulsed Laser Deposition of Coatings from Animal-Origin Calcium Phosphate Sources

Duta

Popescu

2019

Coatings

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The aim of this paper is to present the current status on animal-origin hydroxyapatite (HA) coatings synthesized by Pulsed Laser Deposition (PLD) technique for medical implant applications. PLD as a thin film synthesis method, although limited in terms of surface covered area, still gathers interest among researchers due to its advantages such as stoichiometric transfer, thickness control, film adherence, and relatively simple experimental set-up. While animal-origin HA synthesized by bacteria or extracted from animal bones, eggshells, and clams was tested in the form of thin films or scaffolds as a bioactive agent before, the reported results on PLD coatings from HA materials extracted from natural sources were not gathered and compared until the present study. Since natural apatite contains trace elements and new functional groups, such as CO32− and HPO42− in its complex molecules, physical-chemical results on the transfer of animal-origin HA by PLD are extremely interesting due to the stoichiometric transfer possibilities of this technique. The points of interest of this paper are the origin of HA from various sustainable resources, the extraction methods employed, the supplemental functional groups, and ions present in animal-origin HA targets and coatings as compared to synthetic HA, the coatings’ morphology function of the type of HA, and the structure and crystalline status after deposition (where properties were superior to synthetic HA), and the influence of various dopants on these properties. The most interesting studies published in the last decade in scientific literature were compared and morphological, elemental, structural, and mechanical data were compiled and interpreted. The biological response of different types of animal-origin apatites on a variety of cell types was qualitatively assessed by comparing MTS assay data of various studies, where the testing conditions were possible. Antibacterial and antifungal activity of some doped animal-origin HA coatings was also discussed.

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A New Natural Biomaterial: Sheep Dentine Derived Hydroxyapatite

Cited by 9 publications

References 21 publications

Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

Advances in biomaterial production from animal derived waste

Current Status on Pulsed Laser Deposition of Coatings from Animal-Origin Calcium Phosphate Sources

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