A New Method for Documenting Lens Opacities

Adamsons, Ingrid; Taylor, Kathryn I; Enger, Cheryl; Taylor, Hugh R.

doi:10.1016/s0002-9394(14)76899-0

Cited by 33 publications

(11 citation statements)

References 14 publications

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“…Using our method, the coefficient of variation for repeated analyses of the same image (1%) is in agreement with that obtained by other similar methods (2.3%) [18]. A comparison of the reproducibility of different images between our method and that of others is not possible because, in the literature, various methods were used to determine the reproducibility and no individual measurements were given.…”

Section: Discussionsupporting

confidence: 85%

Lens reflectometry with a CCD video camera and computer image analysis

Brom¹,

Siertsema²,

Kooijman³

et al. 1991

Doc Ophthalmol

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Lens reflectometry is a useful method of determining the back scatter of light from the cataractous lens. Making use of normal programmes, the personal computer can be used for the quantitative determination of the lens reflex, as seen in the slit-lamp image. If three different images of the same eye are compared, it appears that the mean variation in the back-scatter readings made by our method is 8.3%.

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Section: Discussionsupporting

confidence: 85%

Lens reflectometry with a CCD video camera and computer image analysis

Brom¹,

Siertsema²,

Kooijman³

et al. 1991

Doc Ophthalmol

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“…The objectives of our study were (1) to compare the clinical assessment of the level of nuclear opacity and the results of densitomet- ric analysis of the lens and (2) to define the most clinically relevant features among the various measurements obtained from the densitometric analysis.…”

Section: Objectivesmentioning

confidence: 99%

“…Various equipments for photodocumentation of cataract changes and systems for clinical grading of lens opacities have been proposed for epidemiological studies [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]. Different features of computerised analysis of Scheimpflug slit images can be chosen to indicate a level of lens opacification or progression of cataract [4,[18][19][20][21][22][23][24][25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Clinical and Digital Assessment of Nuclear Optical Density

et al. 1999

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To compare the standardised Nidek EAS-1000 densitometric analysis of the lens with clinical assessment of the nucleus at an early stage of cataract development, 1,200 eyes of 1,204 participants of the VECAT study were assessed at the baseline using both subjective and objective lens grading. Standardisation of the automatic slit image analysis was achieved using a custom-designed EAS-1000 Software version 3.01c. Among 6 measurements of nuclear optical density, the mean pixel luminescence of integrated anterior nuclear density correlated best with clinical assessment (R = 0.662, p < 0.001). Variance components that interfere with the assessment are defined.

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“…Flash level was 100 Watt-seconds and the slit length was 4.4 mm. The area of the opacity, in pixels, was analyzed using an EAS-1000 (34,35). The outline of the slit lens image was determined by selecting 4 points on the image.…”

Section: Image Analysismentioning

confidence: 99%

Preventive Effect of Eye Drops of Liposomes Containing Disulfiram and Cefmetazole on Selenite-Induced Cataract in Rat Pups

et al. 2006

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Disulfiram (DSF) and cefmetazole (CMZ), which possess with anti-oxidative activities were tested for anti-cataract effect in rats and were compared with pirenoxine (PRX), which is a marketed product used for the treatment of cataract. These compounds were encapsulated in liposomes and the results were compared with the anti-cataract effect of suspension and solution formulations containing same contents of each other agents. Instillations of DSF-and CMZ-liposomes prevented the development of cataract in seleniteinjected rat pups. On the other hand, no anti-cataract effects were observed in selenite-induced cataract rats instilled with DSF suspensions and CMZ solutions. The reduced form of glutathione (GSH) content of the lenses was decreased by approximately 60% of normal level 96 h after the sodium selenite-injection and the calcium (Ca 2+ ) content was increased. The decreased GSH and increased Ca 2+ levels were prevented by instillation of DSF-and CMZliposomes. Instillation of PRX-liposomes and 0.03% PRX solution had no effect on the development of cataract. The results of this study confirmed that anti-oxidative agents such as DSF and CMZ were useful to prevent cataract development related to oxidative stress.

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A New Method for Documenting Lens Opacities

Cited by 33 publications

References 14 publications

Lens reflectometry with a CCD video camera and computer image analysis

Lens reflectometry with a CCD video camera and computer image analysis

Comparison of Clinical and Digital Assessment of Nuclear Optical Density

Preventive Effect of Eye Drops of Liposomes Containing Disulfiram and Cefmetazole on Selenite-Induced Cataract in Rat Pups

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