Comparison of Clinical and Digital Assessment of Nuclear Optical Density

Robman, Liubov; McCarty, Catherine A.; Garrett, S. K.M.; Stephenson, Helen; Thomas, Adrian; McNeil, John J; Taylor, Hugh R.

doi:10.1159/000055522

Cited by 27 publications

(19 citation statements)

References 28 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although photographic image analysis densitometry, [14][15][16][17] or digital image analysis [18][19][20] as it becomes more widespread, might provide some more objective measures to enhance our preoperative assessment of cataracts and facilitate studies on progression of lens opacities, 21 the LOCSIII and other cataract grading systems have been shown to have high inter-observer and intra-observer repeatability 13,18,[22][23][24] and to demonstrate some consistency between different classifications. [24][25][26][27] New techniques such as photon spectroscopy for in vivo analysis of lenses remain to be further investigated.…”

Section: Discussionmentioning

confidence: 99%

The relationship between nuclear colour and opalescence on the LOCSIII scale and physical characteristics of cataract nuclei

Smith

El-Brawany

Nassiri

et al. 2002

Eye

View full text Add to dashboard Cite

Purpose To evaluate the compression characteristics of the human lens nucleocortex in relation to its LOCSIII clinical grading. Methods Sixteen subjects undergoing planned extracapsular cataract surgery had pre-operative slit-lamp examination and assessment of cataract LOCSIII grade followed by postoperative in vitro evaluation of the nucleus with measurement of 'linear compressibility' by a purpose-designed caliper incorporating a strain gauge, enabling the derivation of a graph of nuclear compression (D (mm) against applied force (F (N)). Results Nuclear colour correlates with the force required to compress a lens to 75% of its original depth (F75) (R = 0.625, P = 0.017). Nuclear opalescence correlates with the force required to compress a lens to 75% of its original depth (R = 0.651, P = 0.012) and inversely with linear compressibility (⌬D/⌬F, the slope of the graph of nuclear compression against applied force) (R = ؊0.610, P = 0.014). F75 is a direct and linear compressibility is an inverse related parameter of lens nucleus 'hardness'. Conclusion A new instrument is described which allows measurement of 'hardness'-related compression characteristics of the human cataract in vitro. There is a relationship between the LOCSIII clinical classification of nuclear cataracts and mechanical compression characteristics of the cataractous lens. LOCSIII classification may aid the preoperative planning of an appropriate surgical approach to an individual cataract.

show abstract

Section: Discussionmentioning

confidence: 99%

The relationship between nuclear colour and opalescence on the LOCSIII scale and physical characteristics of cataract nuclei

Smith

El-Brawany

Nassiri

et al. 2002

Eye

View full text Add to dashboard Cite

show abstract

“…Implementing Scheimpflug and retroillumination digital photography with computerised analysis of lens opacities has allowed progression of cataract to be measured with great precision. [71][72][73][74][75][76][77][78][79][80][81][82][83][84][85][86][87][88] This method, cost effective for the large epidemiological studies, 89 is probably the best technique for recording cataract changes.…”

Section: Quantification Of Lens Opacity Measurements In Risk Factor Amentioning

confidence: 99%

External factors in the development of cataract

Robman

Taylor

2005

Eye

170

114

View full text Add to dashboard Cite

Aims To provide an update on the risk factors for cataract development. Methods Review of the literature. Results Age and heredity are the most important risk factors associated with the different types of cataract. While the hereditary component is self-explanatory, increasing age serves as a surrogate for a number of potential external risk factors, the effect of which is cumulative. Identification of the risk factors that have a causal effect on cataract development may provide means for cataract prevention. There are only a few risk factors that satisfy the criteria for causal effect: smoking, which results in the increased risk of nuclear cataract, excessive UV-B exposure and diabetes that increase the risk of cortical cataract, and steroidal treatment, diabetes and ionising radiation that lead to the formation of posterior subcapsular opacity. The effect of medications on cataract development requires further study, since the effect of the diseases should be distinguished from that of treatment. 'Stop Smoking' and 'UV-B protection' campaigns are gaining momentum as preventative measures, while the attempts to actively prevent cataract with antioxidants have not been successful. Cataract research has been facilitated lately by improvements of precision and standardisation in measuring lens opacities. However, measurement precision on its own cannot give us a solution to this problem. Conclusion The major studies repeatedly measure the exposure to the traditional health hazards, while the missing parts in the equation are those risk factors that we do not know about and therefore do not measure. New approaches and new hypotheses are needed.

show abstract

“…Robmann et al [10] reported that the cataract density measured by EAS-1000 was significantly correlated with clinical assessment of the nuclear density and therefore its value was used in this study. On the other hand, it is actually difficult to measure the true AL and thus directly evaluate the effect of cataract density on the AL measurement.…”

Section: Introductionmentioning

confidence: 99%

Impact of Nuclear Cataract Density on Postoperative Refractive Outcome: IOL Master versus Ultrasound

et al. 2007

View full text Add to dashboard Cite

Purpose: To evaluate the effect of cataract density on the postoperative refractive outcome. Methods: For 59 nuclear cataract eyes, the axial length was preoperatively measured by the IOL Master (Zeiss, Germany) and ultrasound (US; UD-6000, Tomey, Japan) and the cataract density by EAS-1000 (Nidek, Japan). The prediction error was used as evaluation of the accuracy of ocular biometry. Results: There were significant differences between IOL Master and US in the mean error (0.24 ± 0.63 vs. 0.69 ± 0.64 dpt, p < 0.001) and the mean absolute error (0.57 ± 0.36 vs. 0.79 ± 0.53 dpt, p < 0.001). The cataract density was significantly correlated with the prediction error with IOL Master (r = 0.24, p = 0.03) and US (r = 0.29, p = 0.01). Conclusions: Measurements with the IOL Master are slightly affected by the cataract density due to the refractive index change, but its accuracy is less affected than US.

show abstract

Comparison of Clinical and Digital Assessment of Nuclear Optical Density

Cited by 27 publications

References 28 publications

The relationship between nuclear colour and opalescence on the LOCSIII scale and physical characteristics of cataract nuclei

The relationship between nuclear colour and opalescence on the LOCSIII scale and physical characteristics of cataract nuclei

External factors in the development of cataract

Impact of Nuclear Cataract Density on Postoperative Refractive Outcome: IOL Master versus Ultrasound

Contact Info

Product

Resources

About