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found in eyes with uncomplicated retinal detachments without intraocular fibrosis (360±91 pM [SEMI). Using an in vitro assay, 84-100% of the TGF-,B activity could be blocked with specific antibodies against TGF-fl2, whereas only 10-21% could be blocked by specific antibodies against TGF-,61.TGF-ft, was used in an animal model of traction retinal detachment. Since flI and 2 have essentially identical biologic effects and only human fl1 was available in quantities required, 61 was chosen for these in vivo studies. The injection of TGF-ft, plus fibronectin (FN) but not TGF-,81 alone into the vitreous cavity of rabbits resulted in the increased formation of intraocular fibrosis and traction retinal detachments as compared to control eyes. In previous studies, intravitreal FN levels were also found to be elevated in eyes with intraocular fibrosis.

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