A New Method for Assessing States of Acute Acidaemia in Man

Abstract

1. CO2 titration curves in vivo were determined at various degrees of acute non-respiratory acidaemia in man. 2. The slope of the CO2 titration curve was found to increase as the severity of the acute non-respiratory acidaemia increased. 3. A simple scheme based on the CO2 titration curves in vivo has been proposed for the assessment of acute acidaemia in man.

Acid‐base changes in paediatric anaesthesia*

“…Throughout the operative period the minute volume was measured so that a constant level of intermittent positive pressure ventilation was maintained and further blood samples taken at [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] min intervals. In the recovery phase blood samples were obtained at convenient times.…”

What Is New in Blood-Gas Analysis?

“…The advantage of "non-respiratory pH" as an index of metabolic acidaemia has also been considered (Kappagoda, Linden and Snow, 1970;SiggaardAndersen, 1971;Stoker et al, 1972;Editorial, 1974;Fulop and Fulop, 1974). It is obviously of importance that anyone investigating and treating acid-base disorders should take into account the patient's history and clinical condition and should also be aware of the errors and assumptions inherent in both the raw data and the derived variables.…”

The Assessment of Acid-Base Disturbance in Man by the Use of Carbon Dioxide Titration Curves

“…A method for the assessment of states of acute acidaemia in both dog and man, based on the CO 2 titration curves of blood in vivo, has been previously described (Kappagoda, Linden & Snow, 1970;Stoker, Kappagoda, Grimshaw & Linden, 1972). These authors introduced the use of the non-133 respiratory pH of arterial blood as the index of the non-respiratory component of an acute acidaemia.…”

“…Results obtained in states of acute alkalaemia, and additional results from the normal state, have been considered along with previously published data (Kappagoda et 01.,1970;Stoker et al, 1972;Kappagoda, Stoker, Snow & Linden, 1972) to provide a comprehensive account of all acute acid-base disorders, thus extending the application of this method to include states of acute alkalaemia. Data from both man and dog have been combined and analysed collectively, since it has been shown that there is no significant difference in the respective slopes of the CO 2 titration curves in vivo (e.g.…”

“…Data from both man and dog have been combined and analysed collectively, since it has been shown that there is no significant difference in the respective slopes of the CO 2 titration curves in vivo (e.g. Brackett, Cohen & Schwarz, 1965;Stoker et al, 1972). In addition CO 2titration curves were obtained in patients with chronic acid-base disturbances secondary to both renal disease and chronic CO. retention.…”