A new method for analyzing auditory brain-stem response waveforms using a moving-minimum subtraction procedure of digitized analog recordings

Källstrand, Johan; Lewander, Tommy; Baghdassarian, Eva Juselius; Nielzén, Sören

doi:10.2147/ndt.s59178

Cited by 3 publications

(4 citation statements)

References 14 publications

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“…To further characterize the hearing loss in 3xTgAD and 3xTgAD/Polβ +/− mice, we analyzed their ABR waveforms, labeled from I to VII 46 . The two first waves (waves I and II) are known to be generated from auditory nerves 47 , 48 . Waves III–V come from the higher components of the pathway, such as the cochlear nucleus, superior olivary complex, lateral lemniscus, and inferior colliculus.…”

Section: Resultsmentioning

confidence: 99%

“…1). The first wave (wave I) captures the activity of IHCs, afferent auditory neurons, synaptic transmission, and the synaptic connectivity between them [46][47][48] . Because wave amplitude is difficult to measure at low decibel sounds, we analyzed wave amplitude in response to higher decibel sounds (90 dB) to account for all mice, including those with prominent hearing dysfunction.…”

Section: Discussionmentioning

confidence: 99%

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Early-Onset Hearing Loss in Mouse Models of Alzheimer’s Disease and Increased DNA Damage in the Cochlea

Bohr,

Park,

Sahbaz

et al. 2024

AgingBio

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There is considerable interest in whether sensory deficiency is associated with the development of Alzheimer’s disease (AD). Notably, the relationship between hearing impairment and AD is of high relevance but still poorly understood. In this study, we found early-onset hearing loss in two AD mouse models, 3xTgAD and 3xTgAD/Polβ +/− . The 3xTgAD/Polβ +/− mouse is DNA repair deficient and has more humanized AD features than the 3xTgAD. Both AD mouse models showed increased auditory brainstem response (ABR) thresholds between 16 and 32 kHz at 4 weeks of age, much earlier than any AD cognitive and behavioral changes. The ABR thresholds were significantly higher in 3xTgAD/Polβ +/− mice than in 3xTgAD mice at 16 kHz, and distortion product otoacoustic emission signals were reduced, indicating that DNA damage may be a factor underlying early hearing impairment in AD. Poly ADP-ribosylation and protein expression levels of DNA damage markers increased significantly in the cochlea of the AD mice but not in the adjacent auditory cortex. Phosphoglycerate mutase 2 levels and the number of synaptic ribbons in the presynaptic zones of inner hair cells were decreased in the cochlea of the AD mice. Furthermore, the activity of sirtuin 3 was downregulated in the cochlea of these mice, indicative of impaired mitochondrial function. Taken together, these findings provide new insights into potential mechanisms for hearing dysfunction in AD and suggest that DNA damage in the cochlea might contribute to the development of early hearing loss in AD.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Early-Onset Hearing Loss in Mouse Models of Alzheimer’s Disease and Increased DNA Damage in the Cochlea

Bohr,

Park,

Sahbaz

et al. 2024

AgingBio

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“…Using structural MRI, Chen et al (2021 ) investigated the role of the speech-evoked auditory brainstem response (speech-ABR) and broad language abilities in three- to six-year-old autistic children. The speech-ABR is a neurological test to evaluate the auditory brainstem function in response to auditory stimuli ( Källstrand et al, 2014 ; Spitzer et al, 2015 ). The authors classified participants into subgroups based on their speech-ABR to complex sounds, which was either typical or atypical.…”

Section: Factors Associated With Language In Autistic Childrenmentioning

confidence: 99%

Factors associated with receptive and expressive language in autistic children and siblings: A systematic review

Muès,

Schaubroeck,

Demurie

et al. 2024

Autism & Developmental Language Impairments

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Background & aims Language abilities of autistic children and children at elevated likelihood for autism (EL-siblings) are highly heterogeneous, and many of them develop language deficits. It is as of yet unclear why language abilities of autistic children and EL-siblings vary, although an interaction of multiple influential factors is likely at play. In this review, we describe research articles that identify one or multiple of such factors associated with the receptive or expressive language abilities of autistic children and EL-siblings since the introduction of the DSM-5. Our aim was to identify and summarize factors that are linked to language development in autistic children and siblings in the recent literature to ultimately gain insight into the heterogeneity of language abilities in these children. Methods The search strategy of this review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The following databases were consulted: Embase, MEDLINE, Web of Science Core Collection, and Scopus. Inclusion criteria for studies were the presence of a sample of autistic children no older than 7 years old who were diagnosed with autism spectrum disorder per the criteria of the DSM-5. Intervention studies and studies without an explicitly reported language measure were excluded. Risk of bias assessment was completed using the Newcastle–Ottawa Scales. Ultimately, 55 articles were included in this review. Main contribution Fifty-six factors were identified to be related to receptive or expressive language abilities of autistic children and EL-siblings. They were grouped into three main categories: biological factors; psychosocial and environmental factors; and age-related and developmental factors, each with different subcategories. Although many of the identified variables were only examined in one article, some well-researched associated factors were reported across multiple studies and were present in both autistic children and EL-siblings, in particular joint attention, nonverbal cognitive abilities and frontal EEG power. Better insight in these factors associated with language abilities in autistic children and siblings at elevated likelihood can inform future intervention strategies to reduce language deficits and its corresponding negative consequences in these children. Conclusions Our results confirm that multiple different factors likely underlie language deficits in autism. Important aspects that should be considered are, among others, social factors such as joint attention, child characteristics such as nonverbal cognition, and neurocognitive factors.

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“…*This effect was rendered insignificant after correcting for multiple comparisons (Chen et al, 2021) investigated the role of the speechevoked auditory brainstem response (speech-ABR) and broad language abilities in three-to six-year-old autistic children. The speech-ABR is a neurological test to evaluate the auditory brainstem function in response to auditory stimuli (Källstrand et al, 2014, Spitzer et al, 2015. The authors classified participants into subgroups based on their speech-ABR to complex sounds, which was either typical or atypical.…”

Section: Word Learningmentioning

confidence: 99%

Factors Associated with Receptive and Expressive Language in Autistic Children and Siblings: A systematic review

Mues

Schaubroeck

Demurie

et al. 2023

Preprint

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Background Language abilities of autistic children and children at elevated likelihood for autism (EL-siblings) are highly heterogeneous, and many of them develop language deficits. It is as of yet unclear why language abilities of autistic children and EL-siblings vary, although an interaction of multiple influential factors is likely at play. In this review, we describe research articles that identify one or multiple of such factors associated with the receptive or expressive language abilities of autistic children and EL-siblings since the introduction of the DSM-5. Aims Our aim was to identify and summarize factors that are linked to language development in autistic children and siblings in the recent literature to ultimately gain insight into the heterogeneity of language abilities in these children. Method The search strategy of this review followed the PRISMA guidelines. The following databases were consulted: Embase, MEDLINE, Web of Science Core Collection and Scopus. Inclusion criteria for studies were the presence of a sample of autistic children no older than seven years old who were diagnosed with autism spectrum disorder per the criteria of the DSM-5. Intervention studies and studies without an explicitly reported language measure were excluded. Risk of bias assessment was completed using the Newcastle-Ottawa Scales. Ultimately 54 articles were included in this review. Results 56 factors were identified to be related to receptive or expressive language abilities of autistic children and EL-siblings. They were grouped into three main categories: biological factors; psychosocial and environmental factors; and age-related and developmental factors, each with different subcategories. Although many of the identified variables were only examined in one article, some well-researched associated factors stood out, in particular joint attention, nonverbal cognitive abilities and frontal EEG power. Better insight in these factors shaping language abilities in autistic children and siblings at elevated likelihood can inform future intervention strategies to reduce language deficits and its corresponding negative consequences in these children Conclusions Our results confirm that multiple different factors likely underlie language deficits in autism. Important aspects that should be considered in such a model are, amongst others, social factors such as joint attention, child characteristics such as nonverbal cognition, and neurocognitive factors.

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A new method for analyzing auditory brain-stem response waveforms using a moving-minimum subtraction procedure of digitized analog recordings

Cited by 3 publications

References 14 publications

Early-Onset Hearing Loss in Mouse Models of Alzheimer’s Disease and Increased DNA Damage in the Cochlea

Early-Onset Hearing Loss in Mouse Models of Alzheimer’s Disease and Increased DNA Damage in the Cochlea

Factors associated with receptive and expressive language in autistic children and siblings: A systematic review

Factors Associated with Receptive and Expressive Language in Autistic Children and Siblings: A systematic review

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