Early-Onset Hearing Loss in Mouse Models of Alzheimer’s Disease and Increased DNA Damage in the Cochlea
Vilhelm A. Bohr,
Jae-Hyeon Park,
Burcin Duan Sahbaz
et al.
Abstract:There is considerable interest in whether sensory deficiency is associated with the development of Alzheimer’s disease (AD). Notably, the relationship between hearing impairment and AD is of high relevance but still poorly understood. In this study, we found early-onset hearing loss in two AD mouse models, 3xTgAD and 3xTgAD/Polβ
+/−
. The 3xTgAD/Polβ
+/−
mouse is DNA repair deficient and has more humanized AD features than the 3xTgAD. Both AD mouse models showed in… Show more
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