A New Isoflavone Apioglucoside from the Roots of <i>Dalbergia spinosa</i>

Radha, R; Vasantha, Vairathevar Sivasamy; Pitchumani, Kasi

doi:10.1177/1934578x1501001138

Cited by 2 publications

(2 citation statements)

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“…Dalspinin‐7‐ O ‐ β ‐ d ‐galactopyranoside is a glycosylated isoflavone identified in R. canina fruits at 489 m/z. Therefore, the fragment corresponding to the loss of a hexosyl (galactose = −162 uma) gives a dalspinin aglycone at 327 m/z (Table 2), (Radha, Vasantha, & Pitchumani, 2015).…”

Section: Resultsmentioning

confidence: 99%

LC–DAD/ESI–MS/MS characterization of phenolic constituents in Rosa canina L. and its protective effect in cells

Fetni

Bertella

Ouahab

2020

Biomedical Chromatography

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In an aim to prove the efficiency of polyphenols of Rosa canina fruits in promoting human health. A methanolic extract of R. canina fruits was prepared by successive maceration with solvents of increasing polarity. The polyphenol composition was analyzed by HPLC–DAD–ESI–MS. The biological activity of this extract on SH‐SY5Y cells and HepG2 cells was then studied. The antioxidant activity was tested by various in vitro tests such as DPPH‐radical‐scavenging activity, FRAP assay, hydroxyl radical scavenging assay and total antioxidant capacity. The subacute toxicity of R. canina was tested on female rats by repeated intraperitoneal administration of various doses. The phenolic profiles showed 25 antioxidants distributed into three classes of phenolic compounds: glycosylated and agglomerated flavonoids/isoflavonoids, tannins and phenanthrenes. Qualitative phytochemical analyses showed that this extract lacks alkaloids. The methanolic extract of R. canina fruits has a total antioxidant capacity of 82.69 ± 1.18 μg EAA/mg of methanol extract and the IC50 of the methods used is in the following increasing order: FRAP assay (61.88 μg/ml), then hydroxyl radical scavenging assay (67.45 μg/ml) and then DPPH radical‐scavenging activity (129.81 μg/ml). The extract of R. canina did not cause any phenotypic signs of toxicity or mortality during and after treatment. The LD50 was >5,000 mg/kg, hence, R. canina was considered nontoxic. An in vivo study proved the protective effect of R. canina against cardiac and hepato‐renal toxicities. These results drew the importance of a healthy diet, where diets rich in R. canina fruits can be used as a rich natural source of antioxidants and anticarcinogenic phenolic compounds.

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Section: Resultsmentioning

confidence: 99%

LC–DAD/ESI–MS/MS characterization of phenolic constituents in Rosa canina L. and its protective effect in cells

Fetni

Bertella

Ouahab

2020

Biomedical Chromatography

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“…Kurz, et al, (1881) [22] reported that a spoonful of root powder in a glass of water is sufficient to destroy the effects of alcohol within half an hour even in cases bordering on delirium tremens. Phyto-chemically, several isoflavone compounds such as dalspinin, dalspinosin, caviunin and 5-hydroxy-6-methoxy-3',4'-methylenedioxy-7-[(6-O-β-Dapiofuranosyl-β-D-glucopyranosyl)oxy] isoflavone (dalspinin-7-O-β-D-[apiofuranosy (1->6)] gluco pyranoside), prunetin-4-O-β-D-galactoside, dalspinosin-7-O-β-glucopyranoside were reported from root (Gandidasan, et al, 1998;Radha, et al, 2015) [7,8,30] . Several biological activities on root extracts were reported such as analgesic, anti-inflammatory, antimicrobial, anti-nociceptive, antioxidant, cytotoxicity, cardio vascular effects, diuretic, hypoglycemic, hypothermic, semen coagulant and spermicidal activities (Dhawan, et al, 1977;Senthamarai, et al, 2003;Jaiganesh, et al, 2009a & b;Jaiganesh, et al, 2010;Bala, et al, 2011) [4,2,11,12,13,32] .…”

Section: Introductionmentioning

confidence: 99%

Pharmacognostical studies on <em>Dalbergia spinosa</em> root

Jaiganesh¹,

Tangavelou²,

Senthamarai³

2021

J. Med. Plants Stud.

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Dalbergia spinosa Roxb. (Family: Leguminosae-Papilionoideae), a large climbing shrub commonly found in mangroves along the Coromandel coasts of south India. Root is bitter taste, used to treat inflammations, urinary problems, pain and fever and also reported for various pharmacological properties such as hypothermic, spermicidal, semen coagulant, hypoglycemic, cardio vascular, antimicrobial, diuretic and analgesic. In the present study, pharmacognostical investigation on roots was carried out by determining the morphological, micro scopical and physicochemical parameters. It was found that the root is cylindrical, elongated, tuberous in nature with lateral branches, yellowish brown in colour, slightly sweet taste with aromatic odour. Microscopical evaluation reveals that the presence of brown coloured cork cells and the periderm is distinguished into phellum, phellogen and phelloderm, made up of parenchyma followed by secondary phloem and xylem consists of vessels, fibres and lignified parenchyma. Histochemical studies of the root exhibits the presence of polyphenols, lignins and total proteins in the cortical cells, vessels and phloem respectively.

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A New Isoflavone Apioglucoside from the Roots of Dalbergia spinosa

Cited by 2 publications

References 5 publications

LC–DAD/ESI–MS/MS characterization of phenolic constituents in Rosa canina L. and its protective effect in cells

LC–DAD/ESI–MS/MS characterization of phenolic constituents in Rosa canina L. and its protective effect in cells

Pharmacognostical studies on <em>Dalbergia spinosa</em> root

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