A New Flavonoid Glycoside from Salix denticulata Aerial Parts

Rawat, Usha; Semwal, Sushma; Semwal, Deepak Kumar; Badoni, Ruchi; Bamola, A.

doi:10.3390/m622

Cited by 7 publications

(6 citation statements)

References 9 publications

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“…leaves (Tawfeek et al, 2019), respectively. Compounds (12, 14) were reported in S. denticulate leaves (Rawat et al, 2009;Semwal et al, 2011). S. gilgiana Seemen.…”

Section: Flavonoidsmentioning

confidence: 99%

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Phytochemistry, Pharmacology and Medicinal Uses of Plants of the Genus Salix: An Updated Review

et al. 2021

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The Willows (genus Salix), with more than 330–500 species and 200 hybrids, are trees, shrubs or prostrate plants that are widely distributed in Africa, North America, Europe, and Asia. The genus is traditionally used in folk medicine and represents a valuable source of biologically active compounds among them salicin, a prodrug for salicylic acid. Altogether, 322 secondary metabolites were characterized in the genus including flavonoids 94) (flavonols, flavones, flavanones, isoflavones, flavan-3-ols (catechins and procyanidins), chalcones, dihydrochalcone, anthocyanins, dihydroflavonols), phenolic glycosides (76), organic acids (28), and non-phenolic glycosides (17), sterols and terpenes (17), simple phenolics 13) and lignans 7) in addition to volatiles and fatty acids (69). Furthermore, willows exert analgesic, anti-inflammatory, antioxidant, anticancer, cytotoxic, antidiabetic, antimicrobial, antiobesity, neuroprotective and hepatoprotective activities. The current review provides an updated summary of the importance of willows, their chemical composition and pharmacological activities.

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“…leaves (Tawfeek et al, 2019), respectively. Compounds (12, 14) were reported in S. denticulate leaves (Rawat et al, 2009;Semwal et al, 2011). S. gilgiana Seemen.…”

Section: Flavonoidsmentioning

confidence: 99%

“…bark, leaves and flowers (El-Shazly et al, 2012;Sobeh et al, 2019), S. subserrata Willd. leaves (Balbaa et al, 1979), S. denticulate erial parts (Rawat et al, 2009), S. babylonica L. roots (Singh et al, 2017), S. subserrata Willd. bark and leaves (Hussain et al, 2011).…”

Section: Sterols and Terpenesmentioning

confidence: 99%

Phytochemistry, Pharmacology and Medicinal Uses of Plants of the Genus Salix: An Updated Review

et al. 2021

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“…The plants from Salix genus are known also contain flavonoids, such as 2',5-dihydroxy-4'methoxyflavone-7-O-β-D-glucopyranoside that has been isolated from Salix denticulate [7].…”

Section: Introductionmentioning

confidence: 99%

“…Several studies showed the good biological activities of Salix tetrasperma Roxb such as antibacterial, anti-fungal [8], antidiabetic, antinociceptive, antipyretic [9], antiinflammatory [10], hypoglycaemic [11], [12], insecticidal, in vivo cytotoxicity [12], laxative, diuretic [13], analgesic, and antischistosomal [14]. These biological activities were influenced by the secondary metabolites such as flavonoid [7] and phenolic compounds [15].…”

Section: Introductionmentioning

confidence: 99%

Isolation of Flavonoid Compound and Antioxidant Activity of Salix tetrasperma Roxb. Leaves

Januarti

Santoni

Efdi

2019

ijfac

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Salix Tetrasperma Roxb. is a plant that found in Indonesia were used as traditional medicine such as diabetes and wound healing. In this study, a flavonoid compound of the ethyl acetate extract of Salix tetrasperma Roxb. leaves was isolated by chromatography technique and the antioxidant activity was determined by DPPH assay. The isolation led to obtain 5,7-dihydroxy-3'-methoxyflavone based on NMR spectra. The ethyl acetate extract exhibited the highest antioxidant activity with the IC 50 is 65.89 µg/mL. This study shows that the Salix tetrasperma Roxb. has good potential as source of antioxidant agent.

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“…Analysis of the correlation spectroscopy (COSY and HMBC) placed the two OCH 3 groups at C-3c and C-4c of the B ring in compound 1 [8]. Based on the foregoing analyses and comparison of the spectral data with those of compound 2 isolated from Salix denticulate [9], the structure of compound 1 was established as 5,2c-dihydroxy-3c,4c-dimethoxyflavone-7-O-E-D-glucopyranoside. The small variation between the NMR data of 1 and 2 (Table 1) was possibly due to different substitution patterns in the B ring and the solvent effect.…”

mentioning

confidence: 99%

Isolation and Characterization of a New Flavonoid Glucoside from Aerial Parts of Phrynium placentarium

Bhowmik

Chowdhury

et al. 2015

Chem Nat Compd

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A new flavonoid glucoside (1) has been isolated from the aerial parts of Phrynium placentarium (Marantaceae). The structure of 1 was established as 5,2c-dihydroxy-3c,4c-dimethoxyflavone-7-O-E-D-glucopyranoside by means of chemical and spectral data including 2D NMR studies. Compound 1 was examined for antioxidant and PCSK3 (furin) inhibition efficacy because inhibitors of furin are under consideration as therapeutic agents for treating various diseases, including HIV, influenza, dengue fever, etc. Experimental results showed antioxidant activity with EC 50 value of 100 Pg/mL and PCSK3 inhibition activity with EC 50 value of 80 Pg/mL on spectrophometric assays. Keywords: Phrynium placentarium, Marantaceae, flavonoid glucoside.Phrynium placentarium (Marantaceae) is 1-2 m tall, having basal leaf and flowers two per bract; it is white to yellowish white and grows in wet shaded places in forest lands of Bhutan, Indonesia, Myanmar, Philippines, Thailand, Vietnam, and the northeastern part of India [1]. It is used as a traditional medicine of the local tribes for the treatment of renal disorder [2, 3] but has not been phytochemically studied. We have investigated the aerial parts of this plant for the first time and isolated a light yellow colored compound 1. Compound 1 was characterized by chemical and spectroscopic (NMR and mass) methods and identified as a flavonoid glucoside. To the best of our knowledge, compound 1 is a new natural product. As part of our regular work, compound 1 was examined for its antioxidant as well as furin inhibition activity. This article reports the isolation and structure elucidation of 1 from the aerial parts of P. placentarium and its efficacy as an antioxidant as well as PCSK3 (furin) inhibitor.Compound 1 was isolated as yellowish needles from the methanolic extract of aerial parts of P. placentarium via repeated column chromatography and was assigned the molecular formula C 23 H 24 O 12 by HR-FAB-MS (+) 493.6039 [M + H] + (calcd for [M] + 492.6013). The UV spectrum showed O max at 279 and 350 nm, indicating the presence of the flavonoid skeleton in 1. The IR spectrum showed broad absorption at 3612 cm -1 (OH stretching) along with absorption bands at 1650 and 1600 cm -1 (characteristic of chromone carbonyl), also suggesting the flavonoid-like structure of 1.

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A New Flavonoid Glycoside from Salix denticulata Aerial Parts

Cited by 7 publications

References 9 publications

Phytochemistry, Pharmacology and Medicinal Uses of Plants of the Genus Salix: An Updated Review

Phytochemistry, Pharmacology and Medicinal Uses of Plants of the Genus Salix: An Updated Review

Isolation of Flavonoid Compound and Antioxidant Activity of Salix tetrasperma Roxb. Leaves

Isolation and Characterization of a New Flavonoid Glucoside from Aerial Parts of Phrynium placentarium

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