A new extract of the plant calendula officinalis produces a dual in vitroeffect: cytotoxic anti-tumor activity and lymphocyte activation

Jiménez-Medina, Eva; García-Lora, Angel; Paco, Laura; Algarra, Ignacio; Collado, Antonia; Garrido, Federico

doi:10.1186/1471-2407-6-119

Cited by 132 publications

(95 citation statements)

References 28 publications

(22 reference statements)

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“…Another novel compound, achillinin A, is purified from yarrow and exhibits potential antiproliferative activity to various human lung cancer cell lines (Li et al, 2011). Cancersuppressive action has reported also for Calendula officinalis whereas the laser-activated Calendula extract induces growth inhibitory effect in various human and murine cancer cell lines (Jimenez-Medina et al, 2006). Triterpene glycosides isolated from marigold flowers exhibit the potent cytotoxic activity against human colon cancer, leukemia, and melanoma cells (Ukiya et al, 2006) and the flower extract can suppress the metastatic spread of melanoma cells to lung in mice (Preethi et al, 2010).…”

Section: Herbsmentioning

confidence: 99%

“…This limits their effectiveness and use as chemotherapeutic drugs and highlights an urgent need to develop agents with minimal side effects to normal organs. In order to address this need, the use of natural phytochemicals has entered into the domain of cancer research and increased efforts are being made to isolate bioactive products from medicinal plants (Fan et al, 2012;Jimenez-Medina et al, 2006;Paul et al, 2013;Rajkumar et al, 2009). A wide variety of secondary metabolites obtained from plants have been tested for their ability to treat cancer (Rajkumar et al, 2009) and among at least 250 000 existing plant species more than one thousand are found to possess significant anticancer properties (Aljuraisy et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Estonian folk traditional experiences on natural anticancer remedies: From past to the future

Sak¹,

Jürisoo

Raal

2014

Pharmaceutical Biology

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Context: Despite diagnostic and therapeutic advancements, the burden of cancer is still increasing worldwide. Toxicity of current chemotherapeutics to normal cells and their resistance to tumor cells highlights the urgent need for new drugs with minimal adverse side effects. The use of natural anticancer agents has entered into the area of cancer research and increased efforts are being made to isolate bioactive products from medicinal plants. Objective: To lead the search for plants with potential cytotoxic activity, ethnopharmacological knowledge can give a great contribution. Therefore, the attention of this review is devoted to the natural remedies traditionally used for the cancer treatment by Estonian people over a period of almost 150 years. Methods: Two massive databases, the first one stored in the Estonian Folklore Archives and the second one in the electronic database HERBA (http://herba.folklore.ee/), containing altogether more than 30 000 ethnomedicinal texts were systematically reviewed to compile data about the Estonian folk traditional experiences on natural anticancer remedies.

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Section: Herbsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Estonian folk traditional experiences on natural anticancer remedies: From past to the future

Sak¹,

Jürisoo

Raal

2014

Pharmaceutical Biology

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“…A literatura atual apresenta inúmeros relatos sobre atividade biológica de extratos vegetais, como ação antifúngica (Alaniìs-Garza et al, 2007;Korukluoglu et al, 2008), ação antibacteriana (Zhang et al, 2007;Al-Turki et al, 2008), atividade anti-tumoral (Jiménez-Medina et al, 2006;Kaileh et al, 2007), ação antiinflamatória e analgésica (Bose et al, 2007;Dlìaz-Viciedo et al, 2008) atividade antioxidante (Ferreres et al, 2007;Starzynìska-Janiszewska et al, 2008), dentre outras.…”

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Composição e atividades antioxidante e antimicrobiana dos óleos essenciais de cravo-da-índia, citronela e palmarosa

Scherer

Wagner

Duarte³

et al. 2009

Rev. bras. plantas med.

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RESUMO:Foram avaliadas a ação antioxidante, ação antimicrobiana e a composição dos óleos essenciais de cravo-da-índia (Caryophillus aromaticus L.), citronela (Cymbopogon winterianus) e palmarosa (Cymbopogon martinii). A ação antioxidante foi avaliada pelo método de DPPH (2,2-difenil-1-picril-hidrazila), e a ação antimicrobiana determinada pelo método da microdiluição definindo-se a concentração inibitória mínima para os microrganismos Staphylococcus aureus, Escherichia coli, Salmonella Thyphimurium, Pseudomonas aeruginosa e Clostridium perfringens. A composição química dos óleos foi determinada por CG-DIC e a identificação dos compostos voláteis por CG-EM, em ambos os casos, utilizando uma coluna capilar DB-5. O óleo de cravoda-índia apresentou uma forte atividade antioxidante e ação antimicrobiana moderada a forte, sendo o eugenol o componente majoritário do óleo de cravo-da-índia (83,7%). Por outro lado, as amostras de citronela e palmarosa apresentaram fraca ação antioxidante, porém a ação antimicrobiana foi moderada a forte.Palavras-chave: radicais livres, cravo-da-índia, óleos essenciais, antioxidantes ABSTRACT: Composition and antioxidant and antimicrobial activities of clove, citronella and palmarosa essential oils. Antioxidant and antimicrobial activities, as well as the chemical composition of essential oils of clove (Caryophillus aromaticus L.), citronella (Cymbopogon winterianus) and palmarosa (Cymbopogon martinii) were studied. Antioxidant activity was evaluated by DPPH (2,2-diphenyl-1-picrylhydrazyl) method and the antimicrobial activity determined by the microdilution method. The minimal inhibitory concentration was defined against Staphylococcus aureus, Escherichia coli, Salmonella Thyphimurium, Pseudomonas aeruginosa and Clostridium perfringens. The chemical composition of oils was determined by GC-FID and volatile compounds were identified by GC-MS, using a DB-5 fused silica capillary column. Clove essential oil showed very high antioxidant activity and moderate to high antimicrobial activity, and eugenol was its major compound (83.7%). On the other hand, citronella and palmarosa samples presented low antioxidant activity but showed moderate to high antimicrobial activity.

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“…Although the great development and tremendous progress in science but medical plants have proved to be a major source in the treatment of many diseases and become a successful alternative to many chemical 8 drugs [1]. The coriander plant is a medicinal and aromatic plant that is important for its essential oils.…”

Section: Introductionmentioning

confidence: 99%

Effect of chelating compounds (DTPA) and Brassinolide on some vegetative growth characteristics and macroelement content in Corianderum sativum L.

Al-Halfi

Al-Shammary²

2018

MJS

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in order to study the chelating compound DTPA effect at different concentrations (0,5,10,15,20) mg.L -1 and growth organizer brassinolide at concentrations (0, 0.5, 1, 1.5, 2) mg.L -1 and their interaction on some morphological properties and content of macroelement (nitrogen, phosphorus, potassium) for coriander plant. Randomized complete Block Design (RCBD) was tested with three replicates. The results showed that the application by (DTPA) act to an increase in the mean of stem diameter and the total chlorophyll content in the leaves and concentration of nitrogen and potassium at the concentration of 20 mg.L -1 while no a significant effect on phosphorus concentration compared to the control treatment. Brassinolide increased all the studied characteristics of stem diameter, total chlorophyll content in leaves, concentration of nitrogen and concentration of potassium at concentration of 2 mg.L -1 , while it did not have a significant effect in phosphorus concentration compared to control treatment. The results also showed a significant interaction between the factors of experiment in all the studied characteristics at the concentrations 20 mg.L -1 from DTPA and 2 mg.L -1 from brassinolide except of phosphorous which showed a significant interaction at concentrations 20 mg.L -1 from DTPA and 1, 1.5 mg.L -1 from brassinolide.

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A new extract of the plant calendula officinalis produces a dual in vitroeffect: cytotoxic anti-tumor activity and lymphocyte activation

Cited by 132 publications

References 28 publications

Estonian folk traditional experiences on natural anticancer remedies: From past to the future

Estonian folk traditional experiences on natural anticancer remedies: From past to the future

Composição e atividades antioxidante e antimicrobiana dos óleos essenciais de cravo-da-índia, citronela e palmarosa

Effect of chelating compounds (DTPA) and Brassinolide on some vegetative growth characteristics and macroelement content in Corianderum sativum L.

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