A New Diterpenoid Alkaloid from Aconitum episcopale

Abstract

A new diterpenoid alkaloid with an epoxy ring between C(3) and C(17) was isolated from Aconitum episcopale. The structure was elucidated on the basis of spectral and chemical evidence.

Four New C19‐Diterpenoid Alkaloids from Aconitum nagarum Stapf

“…Based on the above analysis, the structure of compound 4 was determined and named nagarutine D (Figure 1). Eleven known compounds were identified as hypaconitine ( 5), [23] neoline (6), [24] franchetine (7), [25] bullatine F (8), [26] 8-acetylneoline (9), [27] ducloudine B (10), [28] spicatine B (11), [29] yunaconitine (12), [30] 16βacetoxy-cardiopetaline (13), [11] benzoyldeoxyaconine ( 14), [31] forestine (15), [32] (Figure 1) by comparison of their spectral data with those described in the literature. Moreover, compounds (7 -15) were isolated from A. nagarum Stapf.…”

A novel norditerpenoid alkaloid fromAconitum macrorhynchum

“…The EtOAc extract (62 g) was subjected to chromatography over silica gel (1.0 kg, 200-300 mesh), eluting with petroleum ether-EtOAc-Et 3 N (60:1:0.1 ! 0:1:0.1) to afford six fractions (1)(2)(3)(4)(5)(6). Fraction 4 was purified by silica gel column chromatography eluted with petroleum ether-EtOAc-Et 3 N (3:1:0.1 !…”

“…ex Ledeb has long been used in Tibetan folk medicine for the treatment of arthralgia, dysmenorrhea, and colic [3]. As a continuation of our studies on medicinal plants of Aconitum species growing on the Yunnan -Tibet Plateau [4][5][6][7], A. macrorhynchum was examined. Our previous work [8] on this species has resulted in the isolation of two new norditerpenoid alkaloids, macrorhynines A and B, and seven norditerpenoid alkaloids from A. macrorhynchum.…”