In article number 2007991, Yu Luo, Hangrong Chen, and co‐workers report a novel kind of polyvinyl pyrrolidone modified multifunctional iron sulfide nanoparticles (Fe1−xS‐PVP NPs), which can in situ generate highly toxic hydroxyl radicals under a tumor environment and simultaneously produce H2S gas to suppress the activity of the enzyme cytochrome c oxidase in cancer cells. The external stimulation of 808 nm near‐infrared irradiation will further facilitate this process.
A lipase-producing bacterium strain B68 screened from soil samples of China was identified as Pseudomonas fluorescens. With GenomeWalker, the open reading frame of lipase gene lipB68, encoding 476 amino acids, was cloned and expressed in Escherichia coli BL21 (DE3). By affinity chromatography, the recombinant LipB68 protein was purified to the purity of 95%. As a member of lipase subfamily I.3, LipB68 has a unique optimum temperature of 20 degrees C, which was the lowest in this subfamily. In chiral resolution, LipB68 effectively catalyzed the transesterification of both alpha-phenylethanol and alpha-phenylpropanol at 20 degrees C, achieving E values greater than 100 and 60 after 120 h, respectively. Among all the known catalysts in biodiesel production, LipB68 produced biodiesel with a yield of 92% after 12 h, at the lowest temperature of 20 degrees C, and is the first one of the I.3 lipase subfamily reported to be capable of catalyzing the transesterification reaction of biodiesel production. Since lipase-mediated biodiesel production is normally carried out at 35-50 degrees C, the availability of a highly active lipase with a low optimal temperature can provide substantial savings in energy consumption. Thus, this novel psychrophilic lipase (LipB68) may represent a highly competitive energy-saving biocatalyst.
The monotosylates obtained by treatment of α- and β- cyclodextrin with p- methylbenzenesulfonyl chloride reacted with ammonia to give the title compounds. These amines are of unusually low basicity , with pKa values of 8.70 and 8.72, respectively. In water at 25°, the hydrochloride salt of the amine derived from β- cyclodextrin is approximately 40 times more soluble than β-cyclodextrin and, through complexation, the salt increases the solubility of Nabumetone over 800 times.
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