A New Cytotoxic Sesquiterpene Quinone Produced by Penicillium sp. F00120 Isolated from a Deep Sea Sediment Sample

Lin, Xiuping; Zhou, Xuefeng; Wang, Fa‐Zuo; Liu, Kaisheng; Yang, Bin; Yang, Xiong‐Li; Yan, Peng; Liu, Juan; Ren, Zhe; Liu, Yonghong

doi:10.3390/md10010106

Cited by 42 publications

(43 citation statements)

References 22 publications

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“…This effect was also observed with P. chrysogenum cultures grown on MEA and can be explained likewise (58). In addition, the presence of liquid exudate on 2-week-old cultures is a characteristic of this species and may further reduce the emission of fungal fragments (54,59). In contrast, the abiotic variables, including the type of generator and airflow, showed no significant effect on the aerosolized number of submicronic particles from the Aspergillus species.…”

Section: Discussionmentioning

confidence: 72%

Submicronic Fungal Bioaerosols: High-Resolution Microscopic Characterization and Quantification

Afanou

Straumfors

Skogstad

et al. 2014

Appl Environ Microbiol

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dSubmicronic particles released from fungal cultures have been suggested to be additional sources of personal exposure in moldcontaminated buildings. In vitro generation of these particles has been studied with particle counters, eventually supplemented by autofluorescence, that recognize fragments by size and discriminate biotic from abiotic particles. However, the fungal origin of submicronic particles remains unclear. In this study, submicronic fungal particles derived from Aspergillus fumigatus, A. versicolor, and Penicillium chrysogenum cultures grown on agar and gypsum board were aerosolized and enumerated using field emission scanning electron microscopy (FESEM). A novel bioaerosol generator and a fungal spores source strength tester were compared at 12 and 20 liters min ؊1 airflow. The overall median numbers of aerosolized submicronic particles were 2 ؋ 10 5 cm ؊2 , 2.6 ؋ 10 3 cm ؊2 , and 0.9 ؋ 10 3 cm ؊2 for A. fumigatus, A. versicolor, and P. chrysogenum, respectively. A. fumigatus released significantly (P < 0.001) more particles than A. versicolor and P. chrysogenum. The ratios of submicronic fragments to larger particles, regardless of media type, were 1:3, 5:1, and 1:2 for A. fumigatus, A. versicolor, and P. chrysogenum, respectively. Spore fragments identified by the presence of rodlets amounted to 13%, 2%, and 0% of the submicronic particles released from A. fumigatus, A. versicolor, and P. chrysogenum, respectively. Submicronic particles with and without rodlets were also aerosolized from cultures grown on cellophane-covered media, indirectly confirming their fungal origin. Both hyphae and conidia could fragment into submicronic particles and aerosolize in vitro. These findings further highlight the potential contribution of fungal fragments to personal fungal exposure.

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Section: Discussionmentioning

confidence: 72%

Submicronic Fungal Bioaerosols: High-Resolution Microscopic Characterization and Quantification

Afanou

Straumfors

Skogstad

et al. 2014

Appl Environ Microbiol

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“…The deep sea is emerging as a new and interesting source of such microbes; however, only a handful of reports have described new metabolites from fungi derived from this habitat. 5 As a wide stretch of this particular research theme, our present work resulted in the isolation of two new compounds along with 10 known compounds from the deep-seaderived fungal strain Aspergillus sp. SCSIO Ind09F01 isolated from the deep-sea sediment sample of Indian Ocean.…”

Section: Introductionmentioning

confidence: 99%

“…Further solid-phase fermentation of Aspergillus sp. SCSIO Ind09F01 followed by its crude ethyl acetate (EtOAc) extract yielded two new compounds: sydoxanthone C (1) and acremolin B (2) together with 10 known compounds (3)(4)(5)(6)(7)(8)(9)(10)(11)(12): sydoxanthone B (3), 6 engyodontiumone B (4), 7 sydowinin B (5), 8 acremolin (6), 9 diorcinol (7), 10 cordyol C (8), 11 cordyol E (9), 12 methyl 2-hydroxy-4-(3-hydroxyl-5-methylphenoxy)-6-methylbenzoate(10), 13 3,7-dihydroxy-1,9-dimethyldibenzofuran (11) 14 and AGI-B4 (12) 15 ( Figure 1). The cytotoxicity and COX-2 inhibitory activities of these compounds were individually evaluated.…”

Section: Introductionmentioning

confidence: 99%

Sydoxanthone C and acremolin B produced by deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01

et al. 2015

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A new xanthone named sydoxanthone C (1) and a new alkaloid named acremolin B (2), together with 10 known compounds (3-12) were isolated from a deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01. The structures of compounds (1-12) were determined by the extensive 1D, 2D-NMR, High resolution mass spectra (HRESIMS) data. Compounds 7, 8, 11 and 12 showed significant selective cytotoxicities against HeLa, DU145 and U937 cell lines. In addition, compounds 7, 8 and 11 also exhibited COX-2 inhibitory activities with the prominent IC50 values of 2.4, 7.1 and 10.6 μM, respectively.

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“…Due to the frequent rediscovery of the known fungal metabolites from common habitats, fungi from special ecological niches have attracted much attention of natural product researchers (Bugni & Ireland 2004;Rateb & Ebel 2011;Lin et al 2012;Zhou 2014). Marine fungi produce unique and biologically active secondary metabolites (Zhao et al 2010;Deng et al 2013;Suciati et al 2013).…”

Section: Introductionmentioning

confidence: 99%

A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp. ZSDS1-F3

Wang

et al. 2014

Natural Product Research

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(2014) A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp. ZSDS1-F3, Natural Product Research: Formerly Natural Product Letters, 28:14, 1070-1074, DOI: 10.1080/14786419.2014 To link to this article: http://dx.doi.org/10.1080/14786419.2014.905935 PLEASE SCROLL DOWN FOR ARTICLETaylor & Francis makes every effort to ensure the accuracy of all the information (the "Content") contained in the publications on our platform. However, Taylor & Francis, our agents, and our licensors make no representations or warranties whatsoever as to the accuracy, completeness, or suitability for any purpose of the Content. Any opinions and views expressed in this publication are the opinions and views of the authors, and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content should not be relied upon and should be independently verified with primary sources of information. Taylor and Francis shall not be liable for any losses, actions, claims, proceedings, demands, costs, expenses, damages, and other liabilities whatsoever or howsoever caused arising directly or indirectly in connection with, in relation to or arising out of the use of the Content.This One new naphthalene derivative, 1,8-dihydroxynaphthol-1-O-a-L-rhamnopyranoside (1), together with one known a-dibenzopyrone, alternariol (2), and five xanthones (3 -7) were isolated from the sponge-derived fungus Arthrinium sp. ZSDS1-F3. All the isolated compounds (1 -7) were established by comprehensive analysis of the spectral data, especially 1D and 2D NMR (HMQC and HMBC) spectra. In the primary bioassays, compound 3 exhibited moderate COX-2 inhibition, with IC 50 values of 12.2 mM.article may be used for research, teaching, and private study purposes. Any substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing, systematic supply, or distribution in any form to anyone is

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A New Cytotoxic Sesquiterpene Quinone Produced by Penicillium sp. F00120 Isolated from a Deep Sea Sediment Sample

Cited by 42 publications

References 22 publications

Submicronic Fungal Bioaerosols: High-Resolution Microscopic Characterization and Quantification

Submicronic Fungal Bioaerosols: High-Resolution Microscopic Characterization and Quantification

Sydoxanthone C and acremolin B produced by deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01

A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp. ZSDS1-F3

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