Sydoxanthone C and acremolin B produced by deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01

Tian, Yongtao; Qin, Xiaochun; Lin, Xiuping; Kaliyaperumal, Kumaravel; Zhou, Xuefeng; Liu, Juan; Zhang, Ju; Tu, Zhengchao; Liu, Yonghong

doi:10.1038/ja.2015.55

Cited by 43 publications

(27 citation statements)

References 21 publications

(32 reference statements)

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“…Next, we investigated the possibility of selectively identifying sulfur compounds from a mixture containing 1.0 mg each of six microbial compounds: outovirin A and nanaomycin K as sulfur compounds, and acremolin B [21], SF-227 [22], beauvericin [23] and tanzawaic acid B [24] as non-sulfur compounds. This mixture was oxidized as described above using H 2 O 2 and (NH 4 ) 6 Mo 7 O 24 •4H 2 O as a catalyst.…”

Section: Resultsmentioning

confidence: 99%

Screening for Sulfur Compounds by Molybdenum-Catalyzed Oxidation Combined with Liquid Chromatography-Mass Spectrometry

et al. 2020

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The molybdenum (Mo)-catalyzed oxidation of sulfide under neutral conditions yields sulfone. This reaction proceeds more smoothly than olefin epoxidation and primary or secondary alcohol oxidation. In this study, Mo-catalyzed oxidation was used to screen for sulfur compounds (named “MoS-screening”) in microbial broths by liquid chromatography-mass spectrometry (LC/MS). To demonstrate proof-of-concept, known sulfur microbial compounds were successfully identified from a mixture of non-sulfur microbial compounds as sulfinyl or sulfonyl products of Mo-catalyzed oxidation. Then our MoS-screening method was used to screen 300 samples of microbial broth for sulfur compounds. One of the identified compounds was a kitasetaline-containing N-acetyl cysteine moiety produced by an actinomycete strain. These results demonstrate the potential of MoS-screening in the search for new sulfur compounds from microbial sources.

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Section: Resultsmentioning

confidence: 99%

Screening for Sulfur Compounds by Molybdenum-Catalyzed Oxidation Combined with Liquid Chromatography-Mass Spectrometry

et al. 2020

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“…The test compounds were dissolved in DMSO and the final concentration was set as 10 μM. The percentage inhibition has been calculated by comparison with control incubations (Tian et al, 2015b ) ( Supplementary Material ).…”

Section: Methodsmentioning

confidence: 99%

Phenol Derivatives From the Sponge-Derived Fungus Didymellaceae sp. SCSIO F46

et al. 2018

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Seven new phenol derivatives named coleophomones E and F (1, 2), diorcinols L and M (3, 4), 1-hydroxy-6-methyl-11-methoxy-8-hydroxymethylxanthone (5), porric acid E (6), and 7-(2-hydroxyphenyl) butane-7,8,9-triol (7), were isolated from the EtOAc extract of the marine sponge-derived fungus Didymellaceae sp. SCSIO F46, together with 10 known compounds. Their structures were determined by spectroscopic analyses, including NMR, MS, X-ray diffraction, and theoretical calculations. Each of 1 and 2 contains an unusual spiro [cyclohexane-1,2′-inden] moiety, which is relatively seldom in nature products. Cytotoxic and COX-2 inhibitory activities of all purified compounds were tested and evaluated. Compound 3 displayed obvious cytotoxicities against Huh-7, HeLa, DU145 and HL60 cells (IC50 values 5.7–9.6 μM) and weak activities against other five cell lines, while 8 showed weak cytotoxicities against HeLa and HL7702 cells. Compound 6 displayed COX-2 inhibitory activity with IC50 value of 3.3 μM.

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“…Recently acremolin B, 123 , has been isolated from another deep-sea derived fungus Aspergillus sp. from the Indian Ocean [ 92 ].…”

Section: N -Alkylpurines With Substituents Othementioning

confidence: 99%

Marine Alkylpurines: A Promising Group of Bioactive Marine Natural Products

et al. 2018

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Marine secondary metabolites with a purine motif in their structure are presented in this review. The alkylpurines are grouped according to the size of the alkyl substituents and their location on the purine ring. Aspects related to the marine source, chemical structure and biological properties are considered together with synthetic approaches towards the natural products and bioactive analogues. This review contributes to studies of structure–activity relationships for these metabolites and highlights the potential of the sea as a source of new lead compounds in diverse therapeutic fields.

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Sydoxanthone C and acremolin B produced by deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01

Cited by 43 publications

References 21 publications

Screening for Sulfur Compounds by Molybdenum-Catalyzed Oxidation Combined with Liquid Chromatography-Mass Spectrometry

Screening for Sulfur Compounds by Molybdenum-Catalyzed Oxidation Combined with Liquid Chromatography-Mass Spectrometry

Phenol Derivatives From the Sponge-Derived Fungus Didymellaceae sp. SCSIO F46

Marine Alkylpurines: A Promising Group of Bioactive Marine Natural Products

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