A new Biflavonoid from Leaves of<i>Garcinia Nervosa</i>

Parveen, Mehtab; Ilyas, M.; Mushfiq, M.; Busudan, Omer A.; Muhaisen, Hasan M. H.

doi:10.1080/14786410310001620574

Cited by 11 publications

(3 citation statements)

References 9 publications

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“…Other species of the Garcinia genus have been reported to exhibit diverse biological properties, such as anti-inflammatory, antioxidant, antiimmunosuppressive, antitumor promoter, cytotoxicity, antinematodal, antiviral, antiplasmodial, trypanocidal, and antimicrobial activity, and also in healing skin infections and wounds [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. Phytochemical studies of this genus have revealed the presence of xanthones, benzophenones and biflavonoids [ 3 , 11 , 12 , 13 ]. Consequently, we became interested in carrying out a comprehensive investigation of the twigs and leaves of G. madruno .…”

Section: Introductionmentioning

confidence: 99%

Low-Density Lipoprotein (LDL)-Antioxidant Biflavonoids from Garcinia madruno

Osorio

Londoño

2013

Molecules

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Six biflavonoids were isolated from G. madruno, one of which, 7''-O-(6''''-acetyl)-glucoside of morelloflavone, is a new compound identified on the basis of 1D, 2D NMR (HMQC and HMBC) spectroscopic methods and chemical evidence. The antioxidant activity of the biflavonoids against low-density lipoprotein (LDL) peroxidation induced with Cu2+, was studied by means of a TBARS assay. The antioxidant potential of a biflavonoid fraction (BF) was also evaluated and correlated with its biflavonoid content. The flavanone-(3→8'')-flavone biflavonoids displayed antioxidant activity, particularly morelloflavone, which was significantly more potent than quercetin, with a CE50 of 12.36 μg/mL. Lipid peroxidation, was also significantly reduced in the presence of the BF (EC50 = 11.85 μg/mL). These results suggest that the BF is an excellent antioxidant.

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Section: Introductionmentioning

confidence: 99%

Low-Density Lipoprotein (LDL)-Antioxidant Biflavonoids from Garcinia madruno

Osorio

Londoño

2013

Molecules

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“…Selanjutnya AlCl 3 ditambahkan dalam larutan metanol senyawa (1) artinya pada senyawa (1) hanya terdapat gugus hidroksi-karbonil posisi orto (karbonil kelat) dan tidak terdapat orto dihidroksil (Parveen et al 2004).…”

Section: Hasil Dan Pembahasanunclassified

“…Munculnya 2C karbonil, 2C metilen, 2C metin benzilik dan 2-OH khelat merupakan ciri dari senyawa biflavanon. Pada senyawa flavanon δC-3 adalah 43,3 ppm jika ada kopling karbon maka δC adalah 48,0 ppm (Parveen et al 2004). Berdasarkan uraian ini maka kemungkinan struktur yang mendekati untuk senyawa (1) adalah senyawa GB-1a.…”

Section: Hasil Dan Analisa Nuclear Magnetic Resonanceunclassified

Aktivitas Antimalaria GB-1a Kayu Akar Garcinia xanthochymus Hook.F.ex.T.Anderson

Wahyuningsih

2018

Chim. Nat. Acta

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Abstrak: Pada penelitian ini dihasilkan senyawa biflavonoid, GB-1a (1) dari kayu akar Garcinia xanthochymus Hook.f.ex.T.Anderson, Kebun Raya Bogor, Jawa Barat.Senyawa ini dipisahkan dari ekstrak metanol dengan metode ekstraksi maserasi, kemudian dilanjutkan dengan fraksinasi menggunakan kromatogrfi cair vakum (KCV), Kromatografi Kolom Gravitasi (KKG) dan pemurnian dilakukan dengan kromatografi radial. Elusidasi struktur molekul senyawa dilakukan berdasarkan data spektroskopi UV, IR, 1 H dan 13 C-NMR. Selanjutnya hasil uji aktivitas antimalaria menggunakan parasit Plasmodium falciparum strain 3D7 menunjukkan aktivitas yang moderat dengan harga IC 50 0,34µg/mL (1). -1a (1) were produced from the root wood of Garcinia xanthochymus Hook.f.ex.T.Anderson, Botanical Garden Bogor, West Java. This compound was separated from methanol extract by maceration extraction method, then continued with fractionation using vacuum liquid chromatography (KCV), Gravity Column Chromatography (KKG) and purification was carried out by radial chromatography. Elucidation of the molecular structure of the compounds was carried out based on UV, IR, 1 H and 13 C-NMR spectroscopic data. Furthermore, the results of antimalarial activity tests using the Plasmodium falciparum strain 3D7 parasite showed moderate activity at a price of IC 50 0.34 µg / mL (1) Abstract: In this study biflavonoid compounds, GB

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Synthesis of Biologically Relevant Biflavanoids – A Review

Rahman

Riaz

Desai

2007

Chemistry & Biodiversity

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Recent investigations show that naturally occurring biflavanoids possess anti-inflammatory, anticancer, antiviral, antimicrobial, vasorelaxant, and anticlotting activities. These activities have been discovered from the small number of biflavanoid structures that have been investigated, although the natural biflavanoid library is likely to be large. Structurally, biflavanoids are polyphenolic molecules comprised of two identical or non-identical flavanoid units conjoined in a symmetrical or unsymmetrical manner through an alkyl or an alkoxy-based linker of varying length. These possibilities introduce significant structural variation in biflavanoids, which is further amplified by the positions of functional groups--hydroxy, methoxy, keto, or double bond--and stereogenic centers on the flavanoid scaffold. In combination, the class of biflavanoids represents a library of structurally diverse molecules, which remains to be fully exploited. Since the time of their discovery, several chemical approaches utilizing coupling and rearrangement strategies have been developed to synthesize biflavanoids. This review compiles these synthetic approaches into nine different methods including Ullmann coupling of halogenated flavones, biphenyl-based construction of biflavanoids, metal-catalyzed cross-coupling of flavones, Wessely-Moser rearrangements, oxidative coupling of flavones, Ullmann condensation with nucleophiles, nucleophilic substitutions for alkoxy biflavanoids, and dehydrogenation-based or hydrogenation-based synthesis. Newer, more robust synthetic approaches are necessary to realize the full potential of the structurally diverse class of biflavanoids.

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A new Biflavonoid from Leaves ofGarcinia Nervosa

Abstract: The isolation of a new biflavonoid, identified as I-3, II-3, I-5, II-5, I-7, II-7, I-4', II-4'-octahydroxy [I-2', II-2'] biflavone, from the leaves of Garcinia nervosa is reported. The structure was established by chemical and physical means (IR, UV, 1H-NMR, 13C-NMR data).

Cited by 11 publications

References 9 publications

Low-Density Lipoprotein (LDL)-Antioxidant Biflavonoids from Garcinia madruno

Low-Density Lipoprotein (LDL)-Antioxidant Biflavonoids from Garcinia madruno

Aktivitas Antimalaria GB-1a Kayu Akar Garcinia xanthochymus Hook.F.ex.T.Anderson

Synthesis of Biologically Relevant Biflavanoids – A Review

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