A New Biflavonoid from<i>Schinopsis brasiliensis</i>(Anacardiaceae)

Cardoso, Manuela; Lima, Luciano da Silva; David, Juceni P.; Moreira, Bruno Oliveira; Santos, Edlene O. dos; David, Jorge M.; Alves, Clayton Queiroz

doi:10.5935/0103-5053.20150101

Cited by 7 publications

(9 citation statements)

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“…To the best of our knowledge, this is only the second report of the isolation of biflavonoids, and the first report of the isolation of flavonoid glycosides from the genus Ozoroa . However, biflavonoids and flavonoid glycosides have been reported from within the Anacardiaceae [40–45] . Most of these biflavonoids and glycosides were reported from the leaves, consistent with our findings on the constituents of O. obovata leaves.…”

Section: Resultssupporting

confidence: 92%

Antiplasmodial and Cytotoxic Activities of Extract and Compounds from Ozoroa obovata (Oliv.) R. & A. Fern. var. obovata

Tajuddeen

Swart

Hoppe

et al. 2021

Chemistry & Biodiversity

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Ozoroa obovata (Oliv.) R. & A. Fern. var. obovata found in KwaZulu‐Natal in South Africa was investigated for phytochemical constituents, and for antiplasmodial and cytotoxic effects. The plant leaves were collected from the University of KwaZulu‐Natal (UKZN) arboretum on the Pietermaritzburg Campus, in March 2019. The inhibitory activity against 3D7 Plasmodium falciparum was determined using the parasite lactate dehydrogenase (pLDH) assay and cytotoxicity against HeLa cells was evaluated using the resazurin assay. The bioactive compounds were isolated by chromatographic purification and their structures were established with spectroscopic and spectrometric techniques. The plant leaf extract displayed significant antiplasmodial activity at 50 μg/mL and was also cytotoxic against HeLa cells. Chromatographic purification of the extract led to the isolation of two biflavonoids, four flavonoid glycosides, a steroid glycoside, and a megastigmene derivative. The compounds displayed antiplasmodial and antiproliferative activities at 50 μg/mL but the activity was substantially reduced at 10 μg/mL. The activities and compounds are being reported in O. obovata for the first time.

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Section: Resultssupporting

confidence: 92%

Antiplasmodial and Cytotoxic Activities of Extract and Compounds from Ozoroa obovata (Oliv.) R. & A. Fern. var. obovata

Tajuddeen

Swart

Hoppe

et al. 2021

Chemistry & Biodiversity

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“…Previous phytochemical investigations on S. brasiliensis leaves reported the presence of tannins and polyphenols, such as methyl gallate, gallic acid, ellagic acid derivatives (Fernandes et al, 2015), and flavonoids (Cardoso et al, 2015). Phytochemical investigation of the MeOH extract of S. brasiliensis stems showed the presence of a biflavonoid and a chalcone (Cardoso et al, 2015), while from S. brasiliensis bark an alkyl phenol along with a steroid derivative were isolated (Cardoso et al, 2005).…”

Section: Introductionmentioning

confidence: 96%

“…Phytochemical investigation of the MeOH extract of S. brasiliensis stems showed the presence of a biflavonoid and a chalcone (Cardoso et al, 2015), while from S. brasiliensis bark an alkyl phenol along with a steroid derivative were isolated (Cardoso et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Isolation of antioxidant phenolics from Schinopsis brasiliensis based on a preliminary LC-MS profiling

et al. 2017

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“…In addition, other studies evaluated multiresistant microorganisms and observed the modulating effect of the extract with various antibiotics, improving their response [14,15]. These numerous pharmacological proprieties may be due to the bioactive compounds present in this species, which include tannins and polyphenols, such as methyl gallate, gallic acid, and ellagic acid [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Polymeric Nanoparticle Associated with Ceftriaxone and Extract of Schinopsis Brasiliensis Engler against Multiresistant Enterobacteria

et al. 2020

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Bacterial resistance has become an important public health problem. Bacteria have been acquiring mechanisms to resist the action of antimicrobial active pharmaceutical ingredients (API). Based on this, a promising alternative is the use of nanotechnology, since when the systems are presented in nanometric size, there is an increase in the interaction and concentration of the action at the target site improving the activity. Thus, this study aims to develop a polymeric nanoparticle (PN) composed of chitosan and hydroxypropylmethylcellulose, as an innovative strategy for the administration of an association between ceftriaxone and extract of S. brasiliensis, for the treatment of Enterobacteriaceae. From a Box–Behnken design, nanoparticles were obtained and evaluated using the DLS technique, obtaining the particle size between 440 and 1660 nm, IPD from 0.42 to 0.92, and positive charges. Morphological characteristics of PN by SEM revealed spherical morphology and sizes similar to DLS. Infrared spectroscopy showed no chemical interaction between the components of the formulation. The broth microdilution technique evaluated their antimicrobial activity, and a considerable improvement in the activity of the extract and the API compared to the free compounds was found, reaching an improvement of 133 times in the minimum inhibitory activity CRO.

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A New Biflavonoid fromSchinopsis brasiliensis(Anacardiaceae)

Cited by 7 publications

References 0 publications

Antiplasmodial and Cytotoxic Activities of Extract and Compounds from Ozoroa obovata (Oliv.) R. & A. Fern. var. obovata

Antiplasmodial and Cytotoxic Activities of Extract and Compounds from Ozoroa obovata (Oliv.) R. & A. Fern. var. obovata

Isolation of antioxidant phenolics from Schinopsis brasiliensis based on a preliminary LC-MS profiling

Polymeric Nanoparticle Associated with Ceftriaxone and Extract of Schinopsis Brasiliensis Engler against Multiresistant Enterobacteria

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