A New Application of Lipid Nanoemulsions as Coating Agent, Providing Zero-Order Hydrophilic Drug Release from Tablets

Abstract

The objective of the present investigation was to evaluate potential of nanoemulsions as a coating material for the tablets. The nanoemulsion of size less than 100 nm was prepared using a simple and low-energy spontaneous emulsification method. Conventional tablets containing theophylline as a model hydrophilic drug were prepared. The theophylline tablets were coated with the nanoemulsion using a fluid bed coater. The effect of different levels of the nanoemulsion coating on the theophylline release was evaluated. The theophylline tablets containing different levels of the nanoemulsion coating could be successfully prepared. Interestingly, the coating of tablet with the nanoemulsion resulted in zero-order release of theophylline from the tablets. The noncoated theophylline tablets release the entire drug in less than 2 minutes, whereas nanoemulsion coating delayed the release of theophylline from tablets. This investigation establishes the proof of concept for the potential of nanoemulsions as a coating material for tablets.

Sunflower Oil and Protein-based Novel Bigels as Matrices for Drug Delivery Applications—Characterization andin vitroAntimicrobial Efficiency

“…The ratio of d V95 /d 32 (Table 3) gives indication about the polydispersity index of emulsions [33] . The emulsion systems are said to be homogenous, if the polydispersity index is closer to zero [34,35] . The values of polydispersity indexes for all the bigels were >1.5, indicating a high polydispersity [36] .…”