A New Antiplasmodial Compound from the Papuan Marine Sponge Xestospongia sp.

Murtihapsari, Murtihapsari; Suruwaky, Amir M; Kadarusman, Kadarusman; Kurnia, Dikdik; Herlina, Tati; Supratman, Unang

doi:10.15408/jkv.v4i1.6735

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…dengan pelarut heksana: etil asetat (3:1) merupakan fraksi teraktif sebagai antimalaria dengan nilai IC50 7,13 µg/mL. Selain itu, jenis Spons yang sama Xestospongia sp., asal Kaimana Papua Barat dilaporkan memiliki aktivitas antimalaria secara in vitro dengan nilai IC50 berkisar antara 38,15-1,08 x 10 -6 µM (Murtihapsari, 2016;2017;2018;2019;2020). Tujuan penelitian ini untuk mengetahui kandungan metabolit sekunder dan menentukan nilai ED50 dari uji aktivitas antimalaria secara in vivo pada spons laut Xestospongia sp.…”

Section: Kasus Malaria Tertinggi Didominasi Oleh Parasitunclassified

Uji Aktivitas Antimalaria dari Spons Xestospongia sp. Asal Pulau Yapen secara In Vivo

et al. 2021

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It is generally admitted that marine sponge has rich of secondary metabolite as alkaloids, peptides and terpene. Those various compounds can be used for antimalarial drug. This study aims to evaluate the in vivo antimalarial activity and to characterize the effectiveness of dose (ED50) of n-hexane extracted from Xestospongia sp. by using the Plasmodium berghei infected to mices. In the present study, we used Peter’s four day suppressive test, where the mice infected with Plasmodium berghei intra peritoneal with a suspension containing infected red blood cell origin from donor mice with parasitemia. Results of present study exhibited that the sponge Xestospongia sp. contains secondary metabolite including tritepenoid/steroid, alkaloid and saponin. Furthermore, an in vivo test revealed the affectivity dose (ED50) was 0.24 mg/kg of body weight. This finding is categorized a signifant decreasing level of parasitemia. Secara umum, spons laut mempunyai kandungan metabolit sekunder seperti alkaloid, peptide dan terpena. Berbagai senyawa tersebut dapat dimanfaatkan sebagai obat antimalaria. Penelitian ini bertujuan untuk mengetahui kandungan kimia dan mengevaluasi aktivitas antimalarial secara in vivo untuk efektivitas dosis (ED50) ekstrak n-heksana dari spons Xestospongia sp. dengan menggunakan Plasmodium berghei yang diinfeksi ke tikus. Penelitian ini digunakan metode the 4-day Supresive Test, dimana mencit yang diinfeksi Plasmodium berghei secara intra peritoneal dengan suspensi yang mengandung sel darah merah terinfeksi yang berasal dari mencit donor. Hasil penelitian ini menunjukkan adanya kandungan metabolit sekunder diantaranya tritepenoid/steroid, alkaloid dan saponin. Selanjutnya, uji in vivo diperoleh nilai ED50 sebesar 0,24 mg/kg BB dikelompokan sangat baik, yang dapat menurunkan tingkat parasitemia secara signifikan. Dengan demikian, spons laut asal pulau Yapen dapat dijadikan sebagai sumber metabolit potensial untuk obat antimalaria.

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Section: Kasus Malaria Tertinggi Didominasi Oleh Parasitunclassified

Uji Aktivitas Antimalaria dari Spons Xestospongia sp. Asal Pulau Yapen secara In Vivo

et al. 2021

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“…In Indonesia, the giant-barrel Xestospongia spp. is one of the most well-known genera for unique secondary metabolites such as aaptamine, isoaaptamine, demethyl(oxy)aaptamine, 2-(3H-diazirine-3-yl)benzaldehyde, manzamine C, xestosaprols, and N-methylniphatyne A (Agustina et al, 2018;Arai et al, 2016;Calcul et al, 2003;Dai et al, 2010;Millán-Aguiñaga et al, 2010;Murtihapsari et al, 2018). It is thus assumed that sponge-associated fungi from Xestospongia might have the potential to produce structurally diverse compounds.…”

Section: Introductionmentioning

confidence: 99%

Chromanone-type compounds from marine sponge-derived Daldinia eschscholtzii KJMT FP 4.1

2020

J app pharm sci

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In our investigation on chemical diversity of secondary metabolites from marine microorganisms, a sponge-derived fungus was found to produce a glycosylated aromatic compound, karimanone (1). The fungal strain was isolated from an Indonesian sponge Xestospongia sp. collected in Karimunjawa National Park, Central Java, Indonesia, and was identified as Daldinia eschscholtzii based on the internal transcribed spacer rRNA gene sequence. Herein, we describe the isolation and characterization of karimanone (1), a new chromanone-type compound, along with three biosynthetically related metabolites 2-4. All compounds were active against a multidrug-resistant strain of Salmonella enterica ser. Typhi with an MIC of 62.5 μg/ml for compound 2 and 125 μg/ml for compounds 1, 3, and 4.

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A new antiplasmodial sterol from Indonesian marine sponge, Xestospongia sp

Murtihapsari

Salam

Kurnia

et al. 2019

Natural Product Research

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A new antimalarial sterol, kaimanol (1), along with a known sterol, saringosterol (2) was isolated from the Indonesian Marine sponge, Xestospongia sp. The chemical structure of the new compound was determined on the basis of spectroscopic evidences and by comparison to those related compounds previously reported. Isolated compounds, 1 and 2 were evaluated for their antiplasmodial effect against Plasmodium falciparum 3D7 strains. Compounds 1 and 2 exhibited antiplasmodial activity with IC 50 values of 359 and 0.250 nM, respectively.

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A New Antiplasmodial Compound from the Papuan Marine Sponge Xestospongia sp.

Cited by 4 publications

References 21 publications

Uji Aktivitas Antimalaria dari Spons Xestospongia sp. Asal Pulau Yapen secara In Vivo

Uji Aktivitas Antimalaria dari Spons Xestospongia sp. Asal Pulau Yapen secara In Vivo

Chromanone-type compounds from marine sponge-derived Daldinia eschscholtzii KJMT FP 4.1

A new antiplasmodial sterol from Indonesian marine sponge, Xestospongia sp

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