A new antiplasmodial sterol from Indonesian marine sponge, <i>Xestospongia</i> sp

Murtihapsari, Murtihapsari; Salam, Supriatno; Kurnia, Dikdik; Darwati, Darwati; Kadarusman, Kadarusman; Abdullah, Fajar Fauzi; Herlina, Tati; Husna, Muhammad Hafiz; Awang, Khalijah; Shiono, Yoshihito; Azmi, Mohamad Nurul; Supratman, Unang

doi:10.1080/14786419.2019.1611815

Cited by 17 publications

(14 citation statements)

References 18 publications

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“…n-hexane extract. This study went further to postulate that the antiplasmodial activity of a sterol structure is good in the presence of an olefinic moiety and reduced due to the presence of benzoyl moiety [50].…”

Section: Marine-derived Quinones Macrolide Lactones and Sterolmentioning

confidence: 99%

Potentials of marine natural products against malaria, leishmaniasis, and trypanosomiasis parasites: a review of recent articles

et al. 2021

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Background Malaria and neglected communicable protozoa parasitic diseases, such as leishmaniasis, and trypanosomiasis, are among the otherwise called diseases for neglected communities, which are habitual in underprivileged populations in developing tropical and subtropical regions of Africa, Asia, and the Americas. Some of the currently available therapeutic drugs have some limitations such as toxicity and questionable efficacy and long treatment period, which have encouraged resistance. These have prompted many researchers to focus on finding new drugs that are safe, effective, and affordable from marine environments. The aim of this review was to show the diversity, structural scaffolds, in-vitro or in-vivo efficacy, and recent progress made in the discovery/isolation of marine natural products (MNPs) with potent bioactivity against malaria, leishmaniasis, and trypanosomiasis. Main text We searched PubMed and Google scholar using Boolean Operators (AND, OR, and NOT) and the combination of related terms for articles on marine natural products (MNPs) discovery published only in English language from January 2016 to June 2020. Twenty nine articles reported the isolation, identification and antiparasitic activity of the isolated compounds from marine environment. A total of 125 compounds were reported to have been isolated, out of which 45 were newly isolated compounds. These compounds were all isolated from bacteria, a fungus, sponges, algae, a bryozoan, cnidarians and soft corals. In recent years, great progress is being made on anti-malarial drug discovery from marine organisms with the isolation of these potent compounds. Comparably, some of these promising antikinetoplastid MNPs have potency better or similar to conventional drugs and could be developed as both antileishmanial and antitrypanosomal drugs. However, very few of these MNPs have a pharmaceutical destiny due to lack of the following: sustainable production of the bioactive compounds, standard efficient screening methods, knowledge of the mechanism of action, partnerships between researchers and pharmaceutical industries. Conclusions It is crystal clear that marine organisms are a rich source of antiparasitic compounds, such as alkaloids, terpenoids, peptides, polyketides, terpene, coumarins, steroids, fatty acid derivatives, and lactones. The current and future technological innovation in natural products drug discovery will bolster the drug armamentarium for malaria and neglected tropical diseases.

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Section: Marine-derived Quinones Macrolide Lactones and Sterolmentioning

confidence: 99%

Potentials of marine natural products against malaria, leishmaniasis, and trypanosomiasis parasites: a review of recent articles

et al. 2021

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“…Terpenes from sponges with antiplasmodial activity belong to the class of norterpene endoperoxides [17,25], sterols [25,26] meroterpenes [49], diterpenes [37,47,58], and sesquiterpenes [54,61]. Norterpene with cyclic endoperoxides scaffold is very common in Diacarnus genus (family Podospongiidae, order Poecilosclerida) of the marine sponges.…”

Section: Terpenesmentioning

confidence: 99%

“…Meroterpenes (67)(68)(69)(70) from a new Caledonian sponge with antiplasmodial effect showed inhibitory potential against plasmodial kinase Pfnek-1 and a farnesyl transferase (Figure 5) [49]. As we described in the section above, xestoquinone (43), a quinone alkaloid from Xestospongia sp., is also a protein kinase inhibitor (PfPK5 and Pfnek-1), and it was suggested by Desoubzdanne and colleagues [49] that quinone/phenolic scaffold in the meroterpenes may be related to Bromotyrosine alkaloids containing spiroisoxazoline scaffold (20)(21)(22)(23)(24)(25)(26) identified in the Hyatella (Spongiidae family), Aplysinella strongylata (Aplysinellidae family), Pseudoceratina (Pseudoceratinidae family) and Verongula genus (Aplysinidae family), have been reported as inhibitors of malaria parasite as well [40,41,43]. Among them, psammaplysin H (20) showed the best IC 50 potency against 3D7 line of P. falciparum at 0.41 µM and the best selectivity (SI > 97) [43].…”

Section: Terpenesmentioning

confidence: 99%

Metabolites from Marine Sponges and Their Potential to Treat Malarial Protozoan Parasites Infection: A Systematic Review

et al. 2021

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Malaria is an infectious disease caused by protozoan parasites of the Plasmodium genus through the bite of female Anopheles mosquitoes, affecting 228 million people and causing 415 thousand deaths in 2018. Artemisinin-based combination therapies (ACTs) are the most recommended treatment for malaria; however, the emergence of multidrug resistance has unfortunately limited their effects and challenged the field. In this context, the ocean and its rich biodiversity have emerged as a very promising resource of bioactive compounds and secondary metabolites from different marine organisms. This systematic review of the literature focuses on the advances achieved in the search for new antimalarials from marine sponges, which are ancient organisms that developed defense mechanisms in a hostile environment. The principal inclusion criterion for analysis was articles with compounds with IC50 below 10 µM or 10 µg/mL against P. falciparum culture. The secondary metabolites identified include alkaloids, terpenoids, polyketides endoperoxides and glycosphingolipids. The structural features of active compounds selected in this review may be an interesting scaffold to inspire synthetic development of new antimalarials for selectively targeting parasite cell metabolism.

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“…(Demospongiae, Haplosclerida: Petrosiidae; Figure 7 is widely distributed in the Indian and South Pacific Oceans. These animals represent a rich source of secondary metabolites with very different biological properties that have been shown effective as enzymatic inhibitors, anti-malarial, anti-bacterial, vasodilatory, and anti-cancer agents [65][66][67][68][69][70]. Among them, ranieramycins are a group of biologically-active tetrahydroisoquinoline compounds.…”

Section: Poriferamentioning

confidence: 99%

Collective Locomotion of Human Cells, Wound Healing and Their Control by Extracts and Isolated Compounds from Marine Invertebrates

et al. 2020

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The collective migration of cells is a complex integrated process that represents a common theme joining morphogenesis, tissue regeneration, and tumor biology. It is known that a remarkable amount of secondary metabolites produced by aquatic invertebrates displays active pharmacological properties against a variety of diseases. The aim of this review is to pick up selected studies that report the extraction and identification of crude extracts or isolated compounds that exert a modulatory effect on collective cell locomotion and/or skin tissue reconstitution and recapitulate the molecular, biochemical, and/or physiological aspects, where available, which are associated to the substances under examination, grouping the producing species according to their taxonomic hierarchy. Taken all of the collected data into account, marine invertebrates emerge as a still poorly-exploited valuable resource of natural products that may significantly improve the process of skin regeneration and restrain tumor cell migration, as documented by in vitro and in vivo studies. Therefore, the identification of the most promising invertebrate-derived extracts/molecules for the utilization as new targets for biomedical translation merits further and more detailed investigations.

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A new antiplasmodial sterol from Indonesian marine sponge, Xestospongia sp

Cited by 17 publications

References 18 publications

Potentials of marine natural products against malaria, leishmaniasis, and trypanosomiasis parasites: a review of recent articles

Potentials of marine natural products against malaria, leishmaniasis, and trypanosomiasis parasites: a review of recent articles

Metabolites from Marine Sponges and Their Potential to Treat Malarial Protozoan Parasites Infection: A Systematic Review

Collective Locomotion of Human Cells, Wound Healing and Their Control by Extracts and Isolated Compounds from Marine Invertebrates

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