A new antifeedant clerodane diterpenoid from<i>Tinospora cordifolia</i>

Sivasubramanian, Aravind; Narasimha, Krishna Kumari Gadepalli; Rathnasamy, Rishikesan; Campos, Ana M. F. Oliveira

doi:10.1080/14786419.2012.722088

Cited by 36 publications

(15 citation statements)

References 15 publications

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“…The most studied biological property of clerodane-type diterpenes is the insect antifeedant activity [ 104 ]. Clerodane diterpenes such as tincordin ( 50 ), tinosporide ( 51 ), 8-hydroxytinosporide ( 52 ), columbin ( 53 ), 8-hydroxycolumbin ( 54 ), and 10-hydroxycolumbin ( 55 ) ( Figure 23 ) were evaluated for their efficacy as insect antifeedants against Earias vittella , Plutella xylostella , and Spodoptera litura [ 105 ]. All diterpenes showed antifeedant activity and compound 52 was the most effective one [ 105 ].…”

Section: Toxicity Of Diterpenesmentioning

confidence: 99%

An Overview of Biotransformation and Toxicity of Diterpenes

2018

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Diterpenes have been identified as active compounds in several medicinal plants showing remarkable biological activities, and some isolated diterpenes are produced at commercial scale to be used as medicines, food additives, in the synthesis of fragrances, or in agriculture. There is great interest in developing methods to obtain derivatives of these compounds, and biotransformation processes are interesting tools for the structural modification of natural products with complex chemical structures. Biotransformation processes also have a crucial role in drug development and/or optimization. The understanding of the metabolic pathways for both phase I and II biotransformation of new drug candidates is mandatory for toxicity and efficacy evaluation and part of preclinical studies. This review presents an overview of biotransformation processes of diterpenes carried out by microorganisms, plant cell cultures, animal and human liver microsomes, and rats, chickens, and swine in vivo and highlights the main enzymatic reactions involved in these processes and the role of diterpenes that may be effectively exploited by other fields.

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Section: Toxicity Of Diterpenesmentioning

confidence: 99%

An Overview of Biotransformation and Toxicity of Diterpenes

2018

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“…It inhibits the growth of cancer causing microorganisms, inhibit oncogenes and the enzymes related to carcinogenesis [29][30]. Tinocordin, columbin, 8-hydroxycolumbin, 10-hydroxycolumbin are diterpeniod lactones reported in Chloroform extract of T. cordifolia [12]. Another diterpenoid epoxy clerodane from chloroform: methanol extraction of alcoholic extract of T. cordifolia has been reported to possess anti-cancer activity against hepatocellular carcinoma induced by diethylnitrosamine [24].…”

Section: Discussionmentioning

confidence: 99%

“…Formulations of T. cordifolia extract with turmeric are effective in preventing hepatotoxicity [11]. Some recent studies have shown anti-feedent activity of clerodane glycosides isolated from chloroform extract of T. Cordifolia along with anti-cancer activity [12][13].…”

Section: Introductionmentioning

confidence: 99%

Anti-brain cancer activity of chloroform and hexane extracts of Tinospora cordifolia Miers: an in vitro perspective

Sharma

Saggu

Mishra

et al. 2019

Annals of Neurosciences

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Background: Plants have been suggested as safest source of therapeutic agents, with multi targeted mode of action and least side effects. Tinospora cordifolia, commonly known as Guduchi in India, is one of the most highly valued herbs in Ayurvedic medicine. It possesses potential anti-cancer, anti-inflammatory, hepatoprotective, anti-diabetic, immune-stimulatory and various other beneficial activities. Purpose: The present study was aimed to investigate the differentiation inducing potential of chloroform and hexane extracts of T. cordifolia using U87MG glioblastoma and IMR-32 neuroblastoma cell lines as model system. Results: Chloroform (Chl-TCE) and hexane (Hex-TCE) extracts significantly reduced the rate of proliferation and induced cell differentiation as evidenced by MTT assay and immunostaining for GFAP and MAP-2 in glioblastoma and neuroblastoma, respectively. Further these extracts increased the expression of stress markers HSP70 and Mortalin and induced senescence. Chloroform and hexane extracts also inhibited the migration of U87MG glioblastoma and IMR-32 neuroblastoma as indicated by wound scratch assay and supported by reduced expression of NCAM. Furthermore these extracts are not toxic to normal cells as they showed no inhibitory effects on primary astrocytic and neuronal cultures. Conclusions: The present study suggests that chloroform and hexane extracts of T. cordifolia retard the rate of proliferation, induce differentiation and inhibit migration of human glioblastomas and neuroblastomas, thus may act as potential phytotherapeutic intervention in treatment of neural cancers.

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“…Indeed, the higher concentration of the clerodane diterpenoids in younger leaves and insect anti-feedant activities of various clerodanes (Sosa et al , 1994; Klein Gebbinck et al , 2002; Rosselli et al , 2004; Sivasubramanian et al , 2013) suggest that they may serve to protect young susceptible tissues from herbivore attack.…”

Section: Discussionmentioning

confidence: 99%