Anti-brain cancer activity of chloroform and hexane extracts of Tinospora cordifolia Miers: an in vitro perspective

Sharma, Anuradha; Saggu, Sandeep Kaur; Mishra, Rachana; Kaur, Gurcharan

doi:10.5214/ans.0972.7531.260104

Cited by 17 publications

(7 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a study by Thippeswamy and Salimath, TCE inhibited cell proliferation and decreased ascites secretion in Ehrlich ascites tumor (EAT) mice [63]. Anti-tumor effects of TCE are very well reported in various cancer cell lines as well as in mice models [64][65][66]. DL bearing mice also show an alteration in lymphoid organs such as reduction in thymus, enlargement of spleen and lymph nodes [67].…”

Section: Discussionmentioning

confidence: 99%

A Novel Role of Tinospora Cordifolia in Amelioration of Cancer-Induced Systemic Deterioration By Taming Neutrophil Infiltration and Hyperactivation

Rawat¹,

Syeda²,

Shrivastava³

2022

Preprint

View full text Add to dashboard Cite

Cancer has emerged as a systemic disease which targets various organs thus challenging the overall physiology of the host. Recently, we have shown that hyperactive neutrophils infiltrate various organs of tumor bearing host and contribute significantly to gradual systemic deterioration. Therefore, taming neutrophils via potent immunomodulators could be an appropriate therapeutic approach in regulating systemic damage. Tinospora cordifolia (TC), an Ayurvedic panacea, is known for its immense medicinal values in traditional literature and recent reports have also documented its strong immunomodulatory potential. However, whether TC can regulate neutrophils to exert its therapeutic effectiveness has not been deciphered so far. To discern this, we utilized murine model of Dalton’s Lymphoma (DL) wherein, we have earlier reported heightened infiltration of neutrophils and their hyperactivation. Our findings showed that TC treatment significantly reduced neutrophil count in peripheral blood and their infiltration in vital organs of tumor bearing host. Further, it ameliorated neutrophil hyperactivation by down regulating the expression of its key cargoes including neutrophil elastase (NE), myeloperoxidase (MPO), MMP-8, MMP-9 and cathepsin G (CSTG) at early and mid stage of tumor growth. In addition, TC treatment prevented histopathological alterations and restored the normal serum enzyme levels at different stages of tumor growth. Importantly, TC treatment also showed significant reduction in tumor burden which was accompanied by a remarkable increase in survival of the tumor-bearing mice. We conclude that Tinospora cordifolia could limit systemic damage via regulating neutrophil infiltration and hyperactivation which can further lead to cancer control at both prophylactic and therapeutic level.

show abstract

Section: Discussionmentioning

confidence: 99%

A Novel Role of Tinospora Cordifolia in Amelioration of Cancer-Induced Systemic Deterioration By Taming Neutrophil Infiltration and Hyperactivation

Rawat¹,

Syeda²,

Shrivastava³

2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Tinospora cordifolia (TCE) has a strong ability to resist metastasis and induce differentiation in neuroblasts, and IMR-32 cells can be induced by treatment with higher concentrations of TCE. Studies have shown that TCE or phytochemicals derived from this plant can be used as safe pharmacological agents together with conventional drugs [ 146 , 147 ]. Chlorogenic acid (CA) is a plant compound isolated from Eucommia ulmoides , honeysuckle and other plants.…”

Section: Other Tumorsmentioning

confidence: 99%

Research Progress of Natural Small-Molecule Compounds Related to Tumor Differentiation

Liu

Sun

2022

Molecules

View full text Add to dashboard Cite

Tumor differentiation is a therapeutic strategy aimed at reactivating the endogenous differentiation program of cancer cells and inducing cancer cells to mature and differentiate into other types of cells. It has been found that a variety of natural small-molecule drugs can induce tumor cell differentiation both in vitro and in vivo. Relevant molecules involved in the differentiation process may be potential therapeutic targets for tumor cells. Compared with synthetic drugs, natural small-molecule antitumor compounds have the characteristics of wide sources, structural diversity and low toxicity. In addition, natural drugs with structural modification and transformation have relatively concentrated targets and enhanced efficacy. Therefore, using natural small-molecule compounds to induce malignant cell differentiation represents a more targeted and potential low-toxicity means of tumor treatment. In this review, we focus on natural small-molecule compounds that induce differentiation of myeloid leukemia cells, osteoblasts and other malignant cells into functional cells by regulating signaling pathways and the expression of specific genes. We provide a reference for the subsequent development of natural small molecules for antitumor applications and promote the development of differentiation therapy.

show abstract

“…They also prevent the cell migration and inhibit the expression of Neural cell adhesion molecule (NCAM). Diterpeniod lactones such as tinocordin, columbin, 8-hydroxycolumbin, and 10-hydroxycolumbin are reported to be in the chloroform extracts from T. cordifolia stems [61]. The methanol extract and berberine isolated from T. cordifolia exert potential antitumor activity against HCA-7 cells (human colon adenocarcinoma cell line).…”

Section: Anti-cancer Activitymentioning

confidence: 99%

Therapeutic Potential of the Medicinal Plant Tinospora cordifolia–Minireview

Priya¹,

Balasubramanian²,

Shanmugaraj³

et al. 2022

Phyton

View full text Add to dashboard Cite

For thousands of years, plant based herbal medicines have been utilized by millions of people all over the world. Plant materials or products are used in different folk/traditional medical systems, such as the Chinese, African and Indian medical systems, like Siddha, Ayurveda, Unani, and Homeopathy. Tinospora cordifolia (TC) is a medicinal plant belonging to the family Menispermaceae. It is a big deciduous, climbing shrub growing prevalently in the tropical part of Indian subcontinent regions such as India, Pakistan, Nepal, Bhutan, Bangladesh and Srilanka, and in Myanmar, and China. Guduchi, Giloy, Shindilkodi, and Amritha are all the common names for this plant. Extracts from different parts of this herbal plant have been used to treat many diseases. In Ayurvedic medicine, extract from this plant is used for preparing "rasayanas", which is known to cure diabetes, skin diseases, allergic conditions, jaundice, cardiovascular diseases, rheumatoid arthritis, poisoning, and microbial infections. T. cordifolia has a many bioactive phytochemicals that have been isolated from its aerial parts and roots. Many bioactive principles have been reported from this plant which belong to various classes like alkaloids, aliphatic compounds, diterpenoid lactones, phenolics, flavonoids, glycosides, sesquiterpenoids, lignans, steroids and polysaccharides. T. cordifolia possesses medicinal properties such as antioxidant, antiallergic, antiinflammatory, antimicrobial, antiviral, antidote, antitumor, antileprotic, antispasmodic, and antidiabetic properties. The present review will provide a comprehensive therapeutic potential of T. cordifolia.

show abstract

Anti-brain cancer activity of chloroform and hexane extracts of Tinospora cordifolia Miers: an in vitro perspective

Cited by 17 publications

References 39 publications

A Novel Role of <i>Tinospora Cordifolia </i>in<i> </i>Amelioration of Cancer-Induced Systemic Deterioration By Taming Neutrophil Infiltration and Hyperactivation

A Novel Role of <i>Tinospora Cordifolia </i>in<i> </i>Amelioration of Cancer-Induced Systemic Deterioration By Taming Neutrophil Infiltration and Hyperactivation

Research Progress of Natural Small-Molecule Compounds Related to Tumor Differentiation

Therapeutic Potential of the Medicinal Plant Tinospora cordifolia–Minireview

Contact Info

Product

Resources

About