A new anti-HIV lupane acid from <i>Gleditsia sinensis</i> Lam.

Li, Wanhua; Zhang, Xiangming; Tian, Rong-Ren; Zheng, Yong‐Tang; Zhao, Wenming; Qiu, Ming‐Hua

doi:10.1080/10286020600883419

Cited by 41 publications

(32 citation statements)

References 8 publications

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“…This unusual compound, which inhibited syncytia formation by HIV-1-infected C8166 cells with the unusually potent EC 50 \ 0.064 lg/ml (Li et al 2007), can be viewed as derived from a 2,3-dihydroxylupene by oxidation to a seco derivative followed by reclosure of the A-ring, e.g.…”

Section: Oleananesmentioning

confidence: 98%

Anti-HIV activity of natural triterpenoids and hemisynthetic derivatives 2004–2009

Cassels

Asencio²

2010

Phytochem Rev

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The continued advance of HIV-AIDS makes the development of relatively inexpensive, freely accessible, and mechanistically more diverse antiviral therapies an urgent need. Natural products are, directly or indirectly, an important potential source of compounds meeting these conditions. A review of the recent literature indicates that some hemisynthetic triterpenoid derivatives, particularly belonging to the lupane, oleanane and ursane series, may be nearing a stage where they can be used to complement existing therapeutic approaches. On the other hand, although some natural derivatives of tetracyclic terpenoid families have revealed many novel structures and some promise as anti-HIV substances, their chemical modification to improve their potency and selectivity remains practically untouched. While ongoing work with the more 'classical' pentacyclic triterpenoids will continue to be a fertile field for HIV-AIDS drug discovery, the other structural groups offer unprecedented opportunities for the development of additional substances with useful properties and for the discovery of novel targets for antiviral therapy.

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Section: Oleananesmentioning

confidence: 98%

Anti-HIV activity of natural triterpenoids and hemisynthetic derivatives 2004–2009

Cassels

Asencio²

2010

Phytochem Rev

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“…Several studies have shown that an extract of the Gleditsia sinensis fruit inhibits tumor growth in several cell lines (Tang et al, 2007;Zhong et al, 2003). Recent reports suggested the biological activity of its chemical constituents, such as stigmasterol (Lim et al, 2005), ellagic acid glycosides (Zhou et al, 2007a), fl avonoid (Zhou et al, 2007b) and lupane acid (Li et al, 2007). However, the antitumor effect of the extract of Gleditsia sinensis thorns remains unclear.…”

Section: Introductionmentioning

confidence: 97%

“…Gleditsia sinensis, a perennial shrub, has multiple effects: antimutagenetic (Lim et al, 2005), antimicrobial (Zhou et al, 2007a(Zhou et al, , 2007b, anti-HIV (Li et al, 2007), antiallergenic (Shin and Kim, 2000) and antiinfl ammatory (Park and Shin, 1993). Several studies have shown that an extract of the Gleditsia sinensis fruit inhibits tumor growth in several cell lines (Tang et al, 2007;Zhong et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Gleditsia sinensis thorn extract inhibits human colon cancer cells: the role of ERK1/2, G2/M‐phase cell cycle arrest and p53 expression

Lee

Park²,

et al. 2010

Phytotherapy Research

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The thorns of Gleditsia sinensis are used as a medicinal herb in China and Korea. However, the mechanisms responsible for the antitumor effects of the water extract of Gleditsia sinensis thorns (WEGS) remain unknown. HCT116 cells treated with the WEGS at a dose of 800 μg/mL (IC₅₀) showed a significant decrease in cell growth and an increase in cell cycle arrest during the G2/M-phase. G2/M-phase arrest was correlated with increased p53 levels and down-regulation of the check-point proteins, cyclinB1, Cdc2 and Cdc25c. In addition, treatment with WEGS induced phosphorylation of extracellular signal-regulated kinase (ERK), p38 MAP kinase and JNK (c-Jun N-terminal kinases). Moreover, inhibition of ERK by treatment of cells with the ERK-specific inhibitor PD98059 blocked WEGS-mediated p53 expression. Similarly, blockage of ERK function in the WEGS-treated cells reversed cell-growth inhibition and decreased cell cycle proteins. Finally, in vivo WEGS treatment significantly inhibited the growth of HCT116 tumor cell xenografts in nude mice with no negative side effects, including loss of body weight. These results describe the molecular mechanisms whereby the WEGS might inhibit proliferation of colon cancer both in vitro and in vivo, suggesting that WEGS has potential as an anticancer agent for the treatment of malignancies.

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“…Its thorns, called "Jo Gak Ja" in Korea, have been used in traditional medicine for the treatment of swelling, suppuration, carbuncle and skin diseases (Ahn, 2003). A few reports has been published the biological activity of its chemical constituents; stigmasterol has antimutagenic activity (Lim et al, 2005); ellagic acid glycosides and flavonoid has antimicrobial activity (Zhou et al, 2007a,b); lupane acid has anti-HIV activity (Li et al, 2007). Its crude extract showed antitumor activity and inhibitory effects on mast cell-dependent anaphylaxis (Shin and Kim, 2000).…”

Section: Introductionmentioning

confidence: 97%

Gleditsia sinensis thorns inhibit the production of NO through NF-κB suppression in LPS-stimulated macrophages

Park

et al. 2008

Journal of Ethnopharmacology

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A new anti-HIV lupane acid from Gleditsia sinensis Lam.

Cited by 41 publications

References 8 publications

Anti-HIV activity of natural triterpenoids and hemisynthetic derivatives 2004–2009

Anti-HIV activity of natural triterpenoids and hemisynthetic derivatives 2004–2009

Gleditsia sinensis thorn extract inhibits human colon cancer cells: the role of ERK1/2, G2/M‐phase cell cycle arrest and p53 expression

Gleditsia sinensis thorns inhibit the production of NO through NF-κB suppression in LPS-stimulated macrophages

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