Gleditsia sinensis thorns inhibit the production of NO through NF-κB suppression in LPS-stimulated macrophages

Ha, Hyun Hee; Park, Sun Young; Ko, Woo Shin; Kim, Young‐Hee

doi:10.1016/j.jep.2008.05.004

Cited by 19 publications

(15 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They showed significant inhibition at doses as low as 3 mg/kg. Gleditsia sinensis is known to possess anti-allergic and anti-inflammatory activity (Dai et al ., 2002; Ha et al ., 2008). It contains various triterpenoids as major components (Lim et al ., 2005).…”

Section: The Inhibition Of Plant Extracts Against In Vivo Animal Modementioning

confidence: 99%

Therapeutic Potential of Medicinal Plants and Their Constituents on Lung Inflammatory Disorders

Kim

Lim

Kwon

2016

Biomol Ther (Seoul)

View full text Add to dashboard Cite

Acute bronchitis and chronic obstructive pulmonary diseases (COPD) are essentially lung inflammatory disorders. Various plant extracts and their constituents showed therapeutic effects on several animal models of lung inflammation. These include coumarins, flavonoids, phenolics, iridoids, monoterpenes, diterpenes and triterpenoids. Some of them exerted inhibitory action mainly by inhibiting the mitogen-activated protein kinase pathway and nuclear transcription factor-κB activation. Especially, many flavonoid derivatives distinctly showed effectiveness on lung inflammation. In this review, the experimental data for plant extracts and their constituents showing therapeutic effectiveness on animal models of lung inflammation are summarized.

show abstract

Section: The Inhibition Of Plant Extracts Against In Vivo Animal Modementioning

confidence: 99%

Therapeutic Potential of Medicinal Plants and Their Constituents on Lung Inflammatory Disorders

Kim

Lim

Kwon

2016

Biomol Ther (Seoul)

View full text Add to dashboard Cite

show abstract

“…agents, has become necessary. Of these, various parts of Gleditsia sinensis have been evaluated in China and Korea for potential therapeutic effects (23). The fruits and seeds of Gleditsia sinensis have primarily been used for treating apoplexy, headache, asthma and scabies (24).…”

Section: Discussionmentioning

confidence: 99%

“…The fruits and seeds of Gleditsia sinensis have primarily been used for treating apoplexy, headache, asthma and scabies (24). On the other hand, the thorns are used for the treatment of carbuncle, scabies, suppurative skin diseases and anti-inflammatory effects (23). However, the effect and mechanism responsible for anti-tumor treatment with the thorns of Gleditsia sinensis have not yet been fully clarified.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effects of the ethanol extract of Gleditsia sinensis thorns on human colon cancer HCT116 cells in vitro and in vivo

Lee

Cho²,

Kim³

et al. 2009

Oncol Rep

View full text Add to dashboard Cite

Abstract. The thorns of Gleditsia sinensis have traditionally been used in the treatment of several diseases, which includes their use as anti-tumor agents, but there has been no scientific evidence of this anti-tumor effect. However, the present study has identified a novel mechanism for the anti-tumor effect of Gleditsia sinensis thorns in the treatment of colon cancer. Treatment with the ethanol extract of Gleditsia sinensis thorns (EEGS) resulted in significant growth inhibition together with G2/M-phase cell cycle arrest at a dose of 600 μg/ml (IC 50 ) in HCT116 cells. In addition, treatment with EEGS induced p27 expression and down-regulated expression of cyclins and cyclin-dependent kinases. Moreover, EEGS treatment induced phosphorylation of extracellular signal-regulated kinases (ERK), p38 MAP kinase and JNK (c-Jun N-terminal kinases). Among the pathways examined, only PD98059 (ERK-specific inhibitor) abolished EEGS-dependent p27 expression. Similarly, suppression of ERK function reversed EEGS-mediated cell proliferation inhibition and decreased cell cycle proteins. In addition, tumor necrosis factor-· (TNF-·)-induced matrix metalloproteinase-9 (MMP-9) expression was inhibited by EEGS treatment via decreased transcriptional activity of both activator protein-1 (AP-1) and nuclear factor-κB. Finally, EEGS treatment significantly reduced tumor sizes in HCT116 cell-xenografted tumor tissues, which was associated with the changed levels of ERK phosphorylation, p27 and MMP-9 expression. Overall, these results have identified a novel molecular mechanism for EEGS in the treatment of colon cancer and might provide a theoretical basis for the potential therapeutic use of EEGS in the treatment of malignancies.

show abstract

“…Its thorns, called “Jo Gak Ja” in Korea, can be gathered regardless of the season, and have been used in traditional herbal medicine for the treatment of various diseases (Park et al , 2011). Previous studies reported the various biological effects of Gleditsia sinensis Lam., including anti-diabetic, anti-hyperglycemic, antioxidant activity, antiinflammatory, anticancer, anticoagulant activities (Ha et al , 2008; Ko et al , 2007; Lee et al , 2011; Yoo et al , 2010). However, no studies have yet investigated the effects of Gleditsia sinensis Lam.…”

Section: Introductionmentioning

confidence: 99%

Effect of Gleditsia sinensis Lam. Extract on Physico-Chemical Properties of Emulsion-Type Pork Sausages

Jin¹,

Yang²,

Choi³

2017

Korean Journal for Food Science of Animal Resources

View full text Add to dashboard Cite

This study was performed to investigate the effect of Gleditsia sinensis Lam. extract on the physicochemical properties of emulsion-type pork sausages during storage at 10°C for 4 wk. Treatments were as follows: (C, control; T1, sodium ascorbate 0.05%; T2, Gleditsia sinensis Lam. 0.05%; T3, Gleditsia sinensis Lam. 0.1%; T4, Gleditsia sinensis Lam. 0.2%; T5, Gleditsia sinensis Lam. 0.1% + sodium ascorbate 0.05%). The values of pH, moisture content, lightness, redness, and sensory attributes were all significantly decreased, while the yellowness, chroma, hue angle, and texture properties were increased during storage with increase of the Gleditsia sinensis Lam. extract added. In addition, the antioxidant activity and antimicrobial activity in the sausages displayed significant increases (p<0.05). Therefore, although it was concluded that the addition of Gleditsia sinensis Lam. extract is not effective for improvement of the physical properties compared to chemical additives in sausages, it could be applied to meat products as a natural preservatives.

show abstract

Gleditsia sinensis thorns inhibit the production of NO through NF-κB suppression in LPS-stimulated macrophages

Cited by 19 publications

References 31 publications

Therapeutic Potential of Medicinal Plants and Their Constituents on Lung Inflammatory Disorders

Therapeutic Potential of Medicinal Plants and Their Constituents on Lung Inflammatory Disorders

Inhibitory effects of the ethanol extract of Gleditsia sinensis thorns on human colon cancer HCT116 cells in vitro and in vivo

Effect of Gleditsia sinensis Lam. Extract on Physico-Chemical Properties of Emulsion-Type Pork Sausages

Contact Info

Product

Resources

About